LBH-589 (Panobinostat)

A novel broad-spectrum HDAC(histone deacetylase) inhibitor belongs to the hydroxamate class, in Philadelphia chromosome-negative (Ph-) acute lymphoblastic leukemia (ALL). Histone deacetylases (HDACs) are responsible for deacetylating histones and nonhistone proteins, thus regulating gene transcription, protein function, and stability. [1]Aberrant recruitment of HDACs has been shown to play an important role in leukemogenesis, and alterations in the expression and/or activity of HDACs have been also observed in solid tumors. [2] The 50% inhibitory concentration (IC50) value for inhibition of proliferation in MOLT-4 cells is approximately 5 nM and for Reh cells is approximately 20 nM.Similar results were observed at 24 and 72 hours. [3]

Small volumes of LBH-589, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS8506187 is an inhibitor targeting LBH-589. Also known as LBH-589 (Panobinostat).