Conditionnement : 1mg
Téléphone : +1 850 650 7790
Synonyms: LDN193189 Tetrahydrochloride, DM-3189 Tetrahydrochloride, DM3189 Tetrahydrochloride
| Description | LDN-193189 Tetrahydrochloride (DM-3189 Tetrahydrochloride) is a selective inhibitor of BMP type I receptors, inhibiting ALK2 and ALK3 (IC50 = 5/30 nM), with weaker activity against ALK4, ALK5, and ALK7, and can be used for research into progressive osseous fibrodysplasia. |
| Targets & IC50 | ACVR1:5 nM, BMPR1A:7 nM |
| In vitro | LDN-193189 Tetrahydrochloride potently inhibits the kinase activity of ALK4 and ActRIIA with IC50 values of 101 and 210 nM, respectively.[2] |
| In vivo | Method: SCID mice bearing MDA-PCa-118b tumor xenografts were treated with LDN-193189 Tetrahydrochloride (3 mg/kg, intraperitoneal injection, twice daily). Tumor size and body weight were measured weekly to investigate the effect of LDN-193189 Tetrahydrochloride on tumor growth in vivo. Result: Treatment of MDA-PCa-118b tumor-bearing mice with LDN-193189 Tetrahydrochloride resulted in decreased bone formation and attenuated tumor growth. [1] |
| Synonyms | LDN193189 Tetrahydrochloride, DM-3189 Tetrahydrochloride, DM3189 Tetrahydrochloride |
| Molecular Weight | 552.33 |
| Formula | C25H26Cl4N6 |
| Cas No. | 2310134-98-4 |
| Smiles | C1(C2=C3N=CC(C4=CC=C(N5CCNCC5)C=C4)=CN3N=C2)=C6C=CC=CC6=NC=C1.Cl.Cl.Cl.Cl |
| Storage | Store at low temperature,Keep away from moisture, Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||||||||||||
| Solubility Information | H2O: 25 mg/mL (45.26 mM), Sonication is recommended. DMSO: 3.3 mg/mL (5.97 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO/H2O
H2O
Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density. | |||||||||||||||||||||||||||||||
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 µL Tween 80 and mix well until fully clarified.
3) Add 450 µL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
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