Macrophage Inflammatory Protein 3 alpha, Human (MIP-3a Exodus, LARC) (Biotin)
Référence MBS631195-5x0,05mg
Conditionnement : 5x0.05mg
Marque : MyBiosource
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Macrophage Inflammatory Protein 3 Alpha (CCL20) Antibody – Rabbit Polyclonal
For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS631195MBS631195 is an antibody targeting CCL20. Also known as Macrophage Inflammatory Protein 3 alpha, Human (MIP-3a Exodus, LARC) (Biotin). Reactive in Human. Host: Rabbit. More details
Product Overview
Online Datasheet in PDFProduct Name
Macrophage Inflammatory Protein 3 alpha (CCL20), Polyclonal Antibody
Full Product Name
Macrophage Inflammatory Protein 3 alpha, Human (MIP-3a Exodus, LARC) (Biotin)
Product Gene Name
anti-CCL20 antibody
Product Synonym Names
Anti -Macrophage Inflammatory Protein 3 alpha, Human (MIP-3a Exodus, LARC) (Biotin)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a lyophilized powder from a sterile-filtered solution in PBS, pH 7.4. Conjugated to Biotin.
Purity/Purification
Affinity Purified
Purified by antigen affinity chromatography.
Purified by antigen affinity chromatography.
Specificity
Recognizes Macrophage Inflammatory Protein-3 alpha (MIP-3a)
Preparation and Storage
-20 degree C
Molecular Weight
10,762 Da
Chromosome Location
Chromosome: 2; NC_000002.11 (228678558..228682280). Location: 2q33-q37
OMIM
601960
Immunogen
Highly purified, recombinant Macrophage Inflammatory Protein-3 alpha (MIP-3a)
Country of Origin
USA
Reconstitution
The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at- 20 degree C. When reconstituted in sterile water to a concentration of 0.2 mg/ml the antibody is stable for at least six weeks at 2-4 degree C.
Product Categories/Family for anti-CCL20 antibody
Antibodies; Abs to Growth Factors; Cytokines
Applications Tested/Suitable for anti-CCL20 antibody
ELISA (EL/EIA), Western Blot (WB), Neutralization
Application Notes for anti-CCL20 antibody
Neutralization: To yield one-half maximal inhibition [ND50] of the biological activity of hMIP-3-alpha (100 ng/ml), a concentration of 15.0-18.0 ug/ml of this antibody is required.
ELISA: To detect hMIP-3-alpha by direct ELISA (using 100µl/well antibody solution) a concentration of at least 0.5ug/ml of this antibody is required. This antigen affinity purified antibody, in conjunction with compatible secondary reagents, allows the detection of 0.2-0.4 ng/well of recombinant hMIP-3-alpha.
Western Blot: To detect hMIP-3-alpha by Western Blot analysis this antibody can be used at a concentration of 0.1-0.2 ug/ml. Used in conjunction with compatible secondary reagents the detection limit for recombinant hMIP-3-alpha is 1.5-3.0 ng/lane, under either reducing or non-reducing conditions.
ELISA: To detect hMIP-3-alpha by direct ELISA (using 100µl/well antibody solution) a concentration of at least 0.5ug/ml of this antibody is required. This antigen affinity purified antibody, in conjunction with compatible secondary reagents, allows the detection of 0.2-0.4 ng/well of recombinant hMIP-3-alpha.
Western Blot: To detect hMIP-3-alpha by Western Blot analysis this antibody can be used at a concentration of 0.1-0.2 ug/ml. Used in conjunction with compatible secondary reagents the detection limit for recombinant hMIP-3-alpha is 1.5-3.0 ng/lane, under either reducing or non-reducing conditions.
Other Notes
Small volumes of anti-CCL20 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Additional Details
NCBI/Uniprot data below describe general gene information for CCL20. It may not necessarily be applicable to this product.
NCBI Official Full Name
macrophage inflammatory protein 3 alpha
NCBI Official Synonym Full Names
chemokine (C-C motif) ligand 20
NCBI Official Symbol
CCL20
NCBI Official Synonym Symbols
CKb4; LARC; ST38; MIP3A; MIP-3a; SCYA20
UniProt Protein Name
C-C motif chemokine 20
UniProt Synonym Protein Names
Beta-chemokine exodus-1; CC chemokine LARC; Liver and activation-regulated chemokine; Macrophage inflammatory protein 3 alpha; MIP-3-alpha; Small-inducible cytokine A20
Protein Family
C-C motif chemokine
UniProt Gene Name
CCL20
UniProt Synonym Gene Names
LARC; MIP3A; SCYA20
UniProt Entry Name
CCL20_HUMAN
NCBI Protein Information
C-C motif chemokine 20; exodus-1; MIP-3-alpha; CC chemokine LARC; OTTHUMP00000164245; OTTHUMP00000204113; beta chemokine exodus-1; beta-chemokine exodus-1; small-inducible cytokine A20; macrophage inflammatory protein 3 alpha; liver and activation-regulated chemokine; small inducible cytokine subfamily A (Cys-Cys), member 20
NCBI Summary for CCL20
This antimicrobial gene belongs to the subfamily of small cytokine CC genes. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The protein encoded by this gene displays chemotactic activity for lymphocytes and can repress proliferation of myeloid progenitors. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2014]
Show more UniProt Comments for CCL20
CCL20: Chemotactic factor that attracts lymphocytes and, slightly, neutrophils, but not monocytes. Inhibits proliferation of myeloid progenitors in colony formation assays. May be involved in formation and function of the mucosal lymphoid tissues by attracting lymphocytes and dendritic cells towards epithelial cells. C-terminal processed forms have been shown to be equally chemotactically active for leukocytes. Possesses antibacterial activity E.coli 25922 and S.aureus 29213. Belongs to the intercrine beta (chemokine CC) family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Chemokine; Secreted; Secreted, signal peptide; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 2q36.3
Cellular Component: extracellular space; extracellular region
Molecular Function: protein binding; chemokine activity
Biological Process: wound healing; cell-cell signaling; defense response to bacterium; immune response; chemotaxis; inflammatory response; positive regulation of interleukin-1 alpha biosynthetic process; signal transduction; positive regulation of nitric-oxide synthase biosynthetic process
Show more Protein type: Chemokine; Secreted; Secreted, signal peptide; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 2q36.3
Cellular Component: extracellular space; extracellular region
Molecular Function: protein binding; chemokine activity
Biological Process: wound healing; cell-cell signaling; defense response to bacterium; immune response; chemotaxis; inflammatory response; positive regulation of interleukin-1 alpha biosynthetic process; signal transduction; positive regulation of nitric-oxide synthase biosynthetic process
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Product Note
Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.
Product PubMed Publications
Products associated with anti-CCL20 antibody
| Reference Product | PubMed Publications |
|---|---|
| CCR6 antibody | >267 publications with CCL20 and CCR6 |
Pathways associated with anti-CCL20 antibody
| Products by Pathway | Pathway Diagram |
|---|---|
| Chemokine Receptors Bind Chemokines Pathway antibodies | Chemokine Receptors Bind Chemokines Pathway Diagram |
| Chemokine Signaling Pathway antibodies | Chemokine Signaling Pathway Diagram |
| Chemokine Signaling Pathway antibodies | Chemokine Signaling Pathway Diagram |
| Class A/1 (Rhodopsin-like Receptors) Pathway antibodies | Class A/1 (Rhodopsin-like Receptors) Pathway Diagram |
| Cytokine-cytokine Receptor Interaction Pathway antibodies | Cytokine-cytokine Receptor Interaction Pathway Diagram |
| Cytokine-cytokine Receptor Interaction Pathway antibodies | Cytokine-cytokine Receptor Interaction Pathway Diagram |
| G Alpha (i) Signalling Events Pathway antibodies | G Alpha (i) Signalling Events Pathway Diagram |
| GPCR Downstream Signaling Pathway antibodies | GPCR Downstream Signaling Pathway Diagram |
| GPCR Ligand Binding Pathway antibodies | GPCR Ligand Binding Pathway Diagram |
| Peptide Ligand-binding Receptors Pathway antibodies | Peptide Ligand-binding Receptors Pathway Diagram |
Diseases associated with anti-CCL20 antibody
| Disease Name | Pubmed Publications |
|---|---|
| Inflammation Antibodies | >199 publications with CCL20 and Inflammation |
| Neoplasms Antibodies | >94 publications with CCL20 and Neoplasms |
| Skin Diseases Antibodies | >61 publications with CCL20 and Skin Diseases |
| Intestinal Diseases Antibodies | >55 publications with CCL20 and Intestinal Diseases |
| Lung Diseases Antibodies | >44 publications with CCL20 and Lung Diseases |
| Arthritis, Rheumatoid Antibodies | >35 publications with CCL20 and Arthritis, Rheumatoid |
| Nervous System Diseases Antibodies | >34 publications with CCL20 and Nervous System Diseases |
| Asthma Antibodies | >23 publications with CCL20 and Asthma |
| Colitis Antibodies | >21 publications with CCL20 and Colitis |
| Demyelinating Diseases Antibodies | >19 publications with CCL20 and Demyelinating Diseases |
Organs/Tissues associated with anti-CCL20 antibody
| Organ/Tissue Name | Pubmed Publications |
|---|---|
| Blood Antibodies | >338 publications with CCL20 and Blood |
| Intestine Antibodies | >81 publications with CCL20 and Intestine |
| Lung Antibodies | >66 publications with CCL20 and Lung |
| Vascular Antibodies | >46 publications with CCL20 and Vascular |
| Liver Antibodies | >44 publications with CCL20 and Liver |
| Mouth Antibodies | >22 publications with CCL20 and Mouth |
| Brain Antibodies | >19 publications with CCL20 and Brain |
| Kidney Antibodies | >19 publications with CCL20 and Kidney |
| Uterus Antibodies | >15 publications with CCL20 and Uterus |
| Eye Antibodies | >13 publications with CCL20 and Eye |