Biovalley > MAPT Antibody
MAPT Antibody
Référence OASG07050
Conditionnement : 100ul
Marque : Aviva Systems Biology
| Datasheets/Manuals | Printable datasheet for anti-MAPT (OASG07050) antibody |
|---|
| Predicted Species Reactivity | Human, Mouse, Rat, Monkey |
|---|---|
| Product Format | Liquid. 1 mg/mL in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Isotype | IgG |
| Host | Rabbit |
| Application | WB |
| Reconstitution and Storage | Store at -20C. Avoid repeated freeze/thaw cycles. |
| Immunogen | Synthesized peptide derived from human Tau around the non-phosphorylation site of S235. Location: 500-580aa. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Specificity | Tau Polyclonal Antibody detects endogenous levels of Tau protein. |
| Application Info | WB 1:500-1:2000; ELISA 1:20000; |
| Gene Symbol | MAPT |
|---|---|
| Gene Full Name | microtubule-associated protein tau |
| Alias Symbols | TAU, MSTD, PPND, DDPAC, MAPTL, MTBT1, MTBT2, tau-40, FTDP-17, PPP1R103 |
| NCBI Gene Id | 4137; 17762; |
| Description of Target | This gene encodes the microtubule-associated protein tau (MAPT) whose transcript undergoes complex, regulated alternative splicing, giving rise to several mRNA species. MAPT transcripts are differentially expressed in the nervous system, depending on stage of neuronal maturation and neuron type. MAPT gene mutations have been associated with several neurodegenerative disorders such as Alzheimer's disease, Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy. |
| Uniprot ID | P10636, P10637, P19332 |
| Molecular Weight | 80 kDa |
Protein interactions
| Name | # of Products |
|---|---|
| AATF | 46 |
| ARHGEF40 | 14 |
| CAMK2A | 110 |
| CASP3 | 324 |
| CASP6 | 68 |
| CASP7 | 140 |
| CASP8 | 242 |
| EP300 | 986 |
| GSK3A | 63 |
| GSK3B | 566 |
| HDAC6 | 187 |
| HSPA4 | 423 |
| HSPA8 | 331 |
| MAPK12 | 31 |
| MARK1 | 33 |
| MARK4 | 76 |
| OGT | 37 |
| PARK2 | 202 |
| PIN1 | 256 |
| PKN1 | 51 |
| PPP2CA | 290 |
| PPP2R5A | 62 |
| PPP5C | 39 |
| RPS6KA3 | 65 |
| RPS6KB1 | 104 |
| SIRT1 | 310 |
| STAU1 | 85 |
| STUB1 | 399 |
| STXBP1 | 46 |
| TUBA4A | 102 |
| TUBB | 135 |
| UBB | 132 |
| UBC | 7030 |
| UBE2D2 | 170 |
| USP9Y | 8 |
| YWHAB | 404 |
| YWHAZ | 466 |
Biological process
| Name | # of Products |
|---|---|
| Apoptotic process | 586 |
| Cell death | 133 |
| Cellular component disassembly involved in apoptosis | 43 |
| Generation of neurons | 16 |
| Microtubule cytoskeleton organization | 43 |
| Negative regulation of microtubule depolymerization | 17 |
| Positive regulation of axon extension | 24 |
| Positive regulation of microtubule polymerization | 13 |
| Regulation of autophagy | 14 |
| Regulation of microtubule polymerization | 2 |
Cellular components
| Name | # of Products |
|---|---|
| Axon | 179 |
| Cell projection | 157 |
| Cytoplasm | 4549 |
| Cytoskeleton | 630 |
| Cytosol | 1868 |
| Growth cone | 66 |
| Microtubule | 190 |
| Microtubule associated complex | 23 |
| Nuclear periphery | 6 |
| Plasma membrane | 2678 |
| Tubulin complex | 3 |
Protein function
| Name | # of Products |
|---|---|
| Apolipoprotein E binding | 18 |
| Enzyme binding | 898 |
| Lipoprotein particle binding | 36 |
| Microtubule binding | 173 |
| Protein binding | 12191 |
| SH3 domain binding | 272 |
| Structural constituent of cytoskeleton | 188 |
Diseases
| Name | # of Products |
|---|---|
| Alzheimer disease | 138 |
| Disease mutation | 5332 |
| Neurodegeneration | 458 |
| Parkinsonism | 123 |
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