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NG-497 [2598242-66-9]

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Référence NB-64-41283-5mg

Conditionnement : 5mg

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NG-497

(Synonyms: NG497) Copy Product Info

Synonyms: NG497

Catalog No. T73499 Copy Product Info

Purity: 99.85%

NG-497 is a selective, small molecule inhibitor of human adipose triglyceride lipase (ATGL) that targets the enzymatically active patatin-like structural domain of human ATGL.NG-497 binds ATGL in a hydrophobic lumen adjacent to the active site.NG-497 abrogates lipolysis in human adipocytes in a dose-dependent and reversible manner.NG-497 has been shown to be useful in cancer research. can be used in cancer research.

Cas No. 2598242-66-9

With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.

For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.85%

Appearance:Solid

Color:White

Product Introduction

Bioactivity

Description	NG-497 is a selective, small molecule inhibitor of human adipose triglyceride lipase (ATGL) that targets the enzymatically active patatin-like structural domain of human ATGL.NG-497 binds ATGL in a hydrophobic lumen adjacent to the active site.NG-497 abrogates lipolysis in human adipocytes in a dose-dependent and reversible manner.NG-497 has been shown to be useful in cancer research. can be used in cancer research.
In vitro	NG-497 selectively inactivates human and non-human primate ATGL, but not structurally and functionally related lipid hydrolases, and eliminates human adipocytes in a dose-dependent and reversible manner. Lipolysis.[1] NG-497 (40 μM, 80 min) reduces lipolysis-dependent respiration in HepG2 cells without impairing mitochondrial function through off-target effects.[1]
Synonyms	NG497

Chemical Properties

Molecular Weight	315.36
Formula	C₁₈H₂₁NO₄
Cas No.	2598242-66-9
Smiles	C(OC(C)C)(=O)C1=NC(=CC(OC)=C1)C2=CC=C(OCC)C=C2

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 62.5 mg/mL (198.19 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.1710 mL	15.8549 mL	31.7098 mL	158.5490 mL
5 mM	0.6342 mL	3.1710 mL	6.3420 mL	31.7098 mL
10 mM	0.3171 mL	1.5855 mL	3.1710 mL	15.8549 mL
20 mM	0.1585 mL	0.7927 mL	1.5855 mL	7.9274 mL
50 mM	0.0634 mL	0.3171 mL	0.6342 mL	3.1710 mL
100 mM	0.0317 mL	0.1585 mL	0.3171 mL	1.5855 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

Keywords

NG-497NG 497ATGL

Related Tags: NG-497 chemical structure | NG-497 in vitro | NG-497 formula | NG-497 molecular weight

NG-497 [2598242-66-9]

Référence NB-64-41283-5mg

Contactez votre distributeur local :

Marque : Neo Biotech

Contactez votre distributeur local :

NG-497

Product Introduction

Calculator

In Vivo Formulation Calculator (Clear solution)

Dose Conversion

Keywords

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