Nogo Antibody
Référence MBS8582391-0,1mL-FITC
Conditionnement : 0.1mL(FITC)
Marque : MyBiosource
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NOGO Antibody – Rabbit Polyclonal
For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS8582391MBS8582391 is an antibody targeting Nogo. Also known as Nogo Antibody. Reactive in Human, Mouse, Rat, Bovine, Dog, Monkey, Rabbit, Sheep. Host: Rabbit. Rabbit polyclonal antibody to Nogo More details
Product Overview
Online Datasheet in PDFProduct Name
Nogo, Polyclonal Antibody
Full Product Name
Nogo Antibody
Product Gene Name
anti-Nogo antibody
Product Synonym Gene Name
RTN4
Product Synonym Names
KIAA0886; NOGO; Reticulon-4; Foocen; Neurite outgrowth inhibitor; Nogo protein; Neuroendocrine-specific protein; NSP; Neuroendocrine-specific protein C homolog; RTN-x; Reticulon-5
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat, Bovine, Dog, Monkey, Rabbit, Sheep
Form/Format
Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH7.3, 30% glycerol, and 0.01% sodium azide.
Purity/Purification
The antibody was purified by immunogen affinity chromatography.
Specificity
Recognizes endogenous levels of Nogo protein.
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.
Molecular Weight
1192
OMIM
604475
Immunogen
KLH-conjugated synthetic peptide encompassing a sequence within the center region of human Nogo. The exact sequence is proprietary.
Product Categories/Family for anti-Nogo antibody
Primary Antibody
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-Nogo antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-Nogo antibody
WB: 1:500-1:1000
IHC: 1:50-1:200
IHC: 1:50-1:200
Other Notes
Small volumes of anti-Nogo antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Additional Details
NCBI/Uniprot data below describe general gene information for Nogo. It may not necessarily be applicable to this product.
NCBI Official Full Name
Reticulon-4
NCBI Official Synonym Full Names
reticulon 4
NCBI Official Symbol
RTN4
NCBI Official Synonym Symbols
ASY; NSP; NOGO; NOGOC; RTN-X; NOGO-A; NSP-CL; Nogo-B; Nogo-C; RTN4-A; RTN4-C; RTN4-B1; RTN4-B2; NI220/250; Nbla00271; Nbla10545
UniProt Protein Name
Reticulon-4
UniProt Synonym Protein Names
Foocen; Neurite outgrowth inhibitor; Nogo protein; Neuroendocrine-specific protein; NSP; Neuroendocrine-specific protein C homolog; RTN-x; Reticulon-5
Protein Family
Reticulon-4 receptor
UniProt Gene Name
RTN4
UniProt Synonym Gene Names
KIAA0886; NOGO; Nogo protein; NSP
UniProt Entry Name
RTN4_HUMAN
NCBI Protein Information
reticulon-4; foocen; Human NogoA; reticulon 5; My043 protein; neurite outgrowth inhibitor; neurite growth inhibitor 220; neuroendocrine-specific protein C homolog
NCBI Summary for Nogo
This gene belongs to the family of reticulon encoding genes. Reticulons are associated with the endoplasmic reticulum, and are involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells. The product of this gene is a potent neurite outgrowth inhibitor which may also help block the regeneration of the central nervous system in higher vertebrates. Alternatively spliced transcript variants derived both from differential splicing and differential promoter usage and encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Show more UniProt Comments for Nogo
Nogo: Developmental neurite growth regulatory factor with a role as a negative regulator of axon-axon adhesion and growth, and as a facilitator of neurite branching. Regulates neurite fasciculation, branching and extension in the developing nervous system. Involved in down-regulation of growth, stabilization of wiring and restriction of plasticity in the adult CNS. Regulates the radial migration of cortical neurons via an RTN4R-LINGO1 containing receptor complex. Isoform 2 reduces the anti-apoptotic activity of Bcl-xl and Bcl-2. This is likely consecutive to their change in subcellular location, from the mitochondria to the endoplasmic reticulum, after binding and sequestration. Isoform 2 and isoform 3 inhibit BACE1 activity and amyloid precursor protein processing. 6 isoforms of the human protein are produced by alternative splicing.
Protein type: Endoplasmic reticulum; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Inhibitor; Cell development/differentiation
Chromosomal Location of Human Ortholog: 2p16.3
Cellular Component: cell projection; cell soma; endoplasmic reticulum; plasma membrane; integral to endoplasmic reticulum membrane; nuclear envelope; intracellular
Molecular Function: protein binding
Biological Process: regulation of apoptosis; nerve growth factor receptor signaling pathway; apoptosis; cerebral cortex radial glia guided migration; axonal fasciculation; negative regulation of axonogenesis; negative regulation of cell growth; angiogenesis; negative regulation of axon extension; regulation of axonogenesis; regulation of cell migration
Show more Protein type: Endoplasmic reticulum; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Inhibitor; Cell development/differentiation
Chromosomal Location of Human Ortholog: 2p16.3
Cellular Component: cell projection; cell soma; endoplasmic reticulum; plasma membrane; integral to endoplasmic reticulum membrane; nuclear envelope; intracellular
Molecular Function: protein binding
Biological Process: regulation of apoptosis; nerve growth factor receptor signaling pathway; apoptosis; cerebral cortex radial glia guided migration; axonal fasciculation; negative regulation of axonogenesis; negative regulation of cell growth; angiogenesis; negative regulation of axon extension; regulation of axonogenesis; regulation of cell migration
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Product Note
Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.
Product PubMed Publications
Pathways associated with anti-Nogo antibody
| Products by Pathway | Pathway Diagram |
|---|---|
| Axonal Growth Inhibition (RHOA Activation) Pathway antibodies | Axonal Growth Inhibition (RHOA Activation) Pathway Diagram |
| Signal Transduction Pathway antibodies | Signal Transduction Pathway Diagram |
| Signalling By NGF Pathway antibodies | Signalling By NGF Pathway Diagram |
| Spinal Cord Injury Pathway antibodies | Spinal Cord Injury Pathway Diagram |
| P75 NTR Receptor-mediated Signalling Pathway antibodies | P75 NTR Receptor-mediated Signalling Pathway Diagram |
| P75(NTR)-mediated Signaling Pathway antibodies | P75(NTR)-mediated Signaling Pathway Diagram |
| P75NTR Regulates Axonogenesis Pathway antibodies | P75NTR Regulates Axonogenesis Pathway Diagram |
Diseases associated with anti-Nogo antibody
| Disease Name | Pubmed Publications |
|---|---|
| Nervous System Diseases Antibodies | >13 publications with Nogo and Nervous System Diseases |
| Cardiovascular Diseases Antibodies | >7 publications with Nogo and Cardiovascular Diseases |
| Schizophrenia Antibodies | >6 publications with Nogo and Schizophrenia |
| Disease Models, Animal Antibodies | >4 publications with Nogo and Disease Models, Animal |
| Heart Diseases Antibodies | >3 publications with Nogo and Heart Diseases |
| Hypertension Antibodies | >2 publications with Nogo and Hypertension |
| Atherosclerosis Antibodies | >2 publications with Nogo and Atherosclerosis |
| Movement Disorders Antibodies | >2 publications with Nogo and Movement Disorders |
| Carcinoma Antibodies | >2 publications with Nogo and Carcinoma |
| Liver Diseases Antibodies | >1 publications with Nogo and Liver Diseases |
Organs/Tissues associated with anti-Nogo antibody
| Organ/Tissue Name | Pubmed Publications |
|---|---|
| Brain Antibodies | >27 publications with Nogo and Brain |
| Nerve Antibodies | >26 publications with Nogo and Nerve |
| Vascular Antibodies | >12 publications with Nogo and Vascular |
| Muscle Antibodies | >10 publications with Nogo and Muscle |
| Blood Antibodies | >5 publications with Nogo and Blood |
| Heart Antibodies | >4 publications with Nogo and Heart |
| Liver Antibodies | >3 publications with Nogo and Liver |
| Eye Antibodies | >2 publications with Nogo and Eye |
| Embryonic Tissue Antibodies | >2 publications with Nogo and Embryonic Tissue |
| Kidney Antibodies | >2 publications with Nogo and Kidney |