PGP9.5 (Gracile Axonal Dystrophy, Neuron Cytoplasmic Protein 9.5, Park5, Parkinson Disease 5, PGP95, Protein Gene Product 9.5, Ubiquitin Carboxyl-terminal Esterase L1, Ubiquitin Carboxyl-terminal Hydrolase Isozyme L1, Ubiquitin Thioesterase L1, Ubiquitin
Référence MBS6124444-0,1mL
Conditionnement : 0.1mL
Marque : MyBiosource
Contactez votre distributeur local :
Téléphone : +1 850 650 7790
PGP9.5 (Gracile Axonal Dystrophy, Neuron Cytoplasmic Protein 9.5, Park5, Parkinson Disease 5, PGP95, Protein Gene Product 9.5, Ubiquitin Carboxyl-terminal Esterase L1, Ubiquitin Carboxyl-terminal Hydrolase Isozyme L1, Ubiquitin Thioesterase L1, Ubiquitin
PGP9.5 Antibody – Mouse Monoclonal
For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6124444MBS6124444 is an antibody targeting PGP9.5. Also known as PGP9.5 (Gracile Axonal Dystrophy, Neuron Cytoplasmic Protein 9.5, Park5, Parkinson Disease 5, PGP95, Protein Gene Product 9.5, Ubiquitin Carboxyl-terminal Esterase L1, Ubiquitin Carboxyl-terminal… More details
Product Overview
Online Datasheet in PDFProduct Name
PGP9.5, Monoclonal Antibody
Full Product Name
PGP9.5 (Gracile Axonal Dystrophy, Neuron Cytoplasmic Protein 9.5, Park5, Parkinson Disease 5, PGP95, Protein Gene Product 9.5, Ubiquitin Carboxyl-terminal Esterase L1, Ubiquitin Carboxyl-terminal Hydrolase Isozyme L1, Ubiquitin Thioesterase L1, Ubiquitin
Product Gene Name
anti-PGP9.5 antibody
Product Synonym Names
Gracile Axonal Dystrophy; Neuron Cytoplasmic Protein 9.5; Park5; Parkinson Disease 5; PGP95; Protein Gene Product 9.5; Ubiquitin Carboxyl-terminal Esterase L1; Ubiquitin Carboxyl-terminal Hydrolase Isozyme L1; Ubiquitin Thioesterase L1; Ubiquitin Thiolesterase L1; UchL1
Clonality
Monoclonal
Isotype
IgG2a,k
Clone Number
SPM575
Host
Mouse
Species Reactivity
Bovine, Canine, Guinea Pig, Human, Mouse, Porcine, Rabbit, Rat, Sheep, Zebrafish
Form/Format
Supplied as a liquid in 10mM PBS. No preservative added. BSA-Free. Labeled with Alkaline Phosphatase (AP).
Purity/Purification
Purified by Protein A/G Affinity Chromatography.
Specificity
Recognizes PGP9.5. Species Crossreactivity: Bovine, Canine, Guinea pig, Human, Mouse, Porcine, Rabbit, Rat, Sheep, Zebrafish. Others not known.
Preparation and Storage
May be stored at 4 degree C before opening. DO NOT FREEZE! Stable at 4 degree C as an undiluted liquid. Dilute only prior to immediate use. Stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. Freezing alkaline phosphatase conjugates will result in a substantial loss of activity.
Molecular Weight
24,824 Da
Chromosome Location
Chromosome: 4; NC_000004.11 (41258898..41270446). Location: 4p14
OMIM
191342
Immunogen
Native UchL1 (PGP9.5) protein from brain. Cellular Localization: Cytoplasmic
Conjugate
AP
Positive Control
Cerebellum
Product Categories/Family for anti-PGP9.5 antibody
Antibodies; Ubiquitin
Applications Tested/Suitable for anti-PGP9.5 antibody
ELISA (EIA), Immunohistochemistry (IHC) Frozen, Western Blot (WB)
Application Notes for anti-PGP9.5 antibody
WB: 0.5-1ug/ml
Applications are based on unconjugated antibody.
Applications are based on unconjugated antibody.
Product References and Citations for anti-PGP9.5 antibody
1. Day IN et. al. Biochem Society Trans 14:350-351 (1986)
Other Notes
Small volumes of anti-PGP9.5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Additional Details
NCBI/Uniprot data below describe general gene information for PGP9.5. It may not necessarily be applicable to this product.
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
ubiquitin carboxyl-terminal hydrolase isozyme L1
NCBI Official Synonym Full Names
ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
NCBI Official Symbol
UCHL1
NCBI Official Synonym Symbols
PARK5; PGP95; PGP9.5; Uch-L1; PGP 9.5
UniProt Protein Name
Ubiquitin carboxyl-terminal hydrolase isozyme L1
UniProt Synonym Protein Names
Neuron cytoplasmic protein 9.5; PGP 9.5; PGP9.5; Ubiquitin thioesterase L1
Protein Family
Ubiquitin carboxyl-terminal hydrolase
UniProt Gene Name
UCHL1
UniProt Synonym Gene Names
UCH-L1; PGP9.5
UniProt Entry Name
UCHL1_HUMAN
NCBI Protein Information
ubiquitin carboxyl-terminal hydrolase isozyme L1; ubiquitin thioesterase L1; neuron cytoplasmic protein 9.5; ubiquitin C-terminal hydrolase
NCBI Summary for PGP9.5
The protein encoded by this gene belongs to the peptidase C12 family. This enzyme is a thiol protease that hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. This gene is specifically expressed in the neurons and in cells of the diffuse neuroendocrine system. Mutations in this gene may be associated with Parkinson disease.[provided by RefSeq, Sep 2009]
Show more UniProt Comments for PGP9.5
UCHL1: Ubiquitin-protein hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. Also binds to free monoubiquitin and may prevent its degradation in lysosomes. The homodimer may have ATP-independent ubiquitin ligase activity. Monomer. Homodimer. Interacts with SNCA. Interacts with COPS5. Found in neuronal cell bodies and processes throughout the neocortex. Expressed in neurons and cells of the diffuse neuroendocrine system and their tumors. Weakly expressed in ovary. Down-regulated in brains from Parkinson disease and Alzheimer disease patients. Belongs to the peptidase C12 family.
Protein type: Cell development/differentiation; EC 3.4.19.12; Ligase; Protease; Ubiquitin conjugating system
Chromosomal Location of Human Ortholog: 4p14
Cellular Component: nucleoplasm; endoplasmic reticulum membrane; cell soma; axon; cytoplasm; plasma membrane; cytosol
Molecular Function: protein binding; omega peptidase activity; ubiquitin binding; cysteine-type endopeptidase activity; ubiquitin-specific protease activity; alpha-2A adrenergic receptor binding; ligase activity
Biological Process: proteasomal ubiquitin-dependent protein catabolic process; cell proliferation; negative regulation of MAP kinase activity; protein deubiquitination; axon transport of mitochondrion; axon target recognition; eating behavior; neuromuscular process; sensory perception of pain; muscle fiber development; adult walking behavior
Disease: Neurodegeneration With Optic Atrophy, Childhood-onset; Parkinson Disease 5, Autosomal Dominant
Show more Protein type: Cell development/differentiation; EC 3.4.19.12; Ligase; Protease; Ubiquitin conjugating system
Chromosomal Location of Human Ortholog: 4p14
Cellular Component: nucleoplasm; endoplasmic reticulum membrane; cell soma; axon; cytoplasm; plasma membrane; cytosol
Molecular Function: protein binding; omega peptidase activity; ubiquitin binding; cysteine-type endopeptidase activity; ubiquitin-specific protease activity; alpha-2A adrenergic receptor binding; ligase activity
Biological Process: proteasomal ubiquitin-dependent protein catabolic process; cell proliferation; negative regulation of MAP kinase activity; protein deubiquitination; axon transport of mitochondrion; axon target recognition; eating behavior; neuromuscular process; sensory perception of pain; muscle fiber development; adult walking behavior
Disease: Neurodegeneration With Optic Atrophy, Childhood-onset; Parkinson Disease 5, Autosomal Dominant
Research Articles on PGP9.5
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Product Note
Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.
Product PubMed Publications
Products associated with anti-PGP9.5 antibody
| Reference Product | PubMed Publications |
|---|---|
| HSP90AA1 antibody | >2 publications with PGP9.5 and HSP90AA1 |
| CDKN1B antibody | >2 publications with PGP9.5 and CDKN1B |
| NEDD8 antibody | >1 publications with PGP9.5 and NEDD8 |
| LAMP2 antibody | >1 publications with PGP9.5 and LAMP2 |
| HSPA8 antibody | >1 publications with PGP9.5 and HSPA8 |
Pathways associated with anti-PGP9.5 antibody
| Products by Pathway | Pathway Diagram |
|---|---|
| Alpha-synuclein Signaling Pathway antibodies | Alpha-synuclein Signaling Pathway Diagram |
| Parkinson's Disease Pathway antibodies | Parkinson's Disease Pathway Diagram |
| Parkinsons Disease Pathway antibodies | Parkinsons Disease Pathway Diagram |
| Proteasome Degradation Pathway antibodies | Proteasome Degradation Pathway Diagram |
Diseases associated with anti-PGP9.5 antibody
| Disease Name | Pubmed Publications |
|---|---|
| Neoplasms Antibodies | >263 publications with PGP9.5 and Neoplasms |
| Nervous System Diseases Antibodies | >192 publications with PGP9.5 and Nervous System Diseases |
| Brain Diseases Antibodies | >142 publications with PGP9.5 and Brain Diseases |
| Inflammation Antibodies | >46 publications with PGP9.5 and Inflammation |
| Adenocarcinoma Antibodies | >29 publications with PGP9.5 and Adenocarcinoma |
| Peripheral Nervous System Diseases Antibodies | >29 publications with PGP9.5 and Peripheral Nervous System Diseases |
| Cardiovascular Diseases Antibodies | >27 publications with PGP9.5 and Cardiovascular Diseases |
| Disease Models, Animal Antibodies | >27 publications with PGP9.5 and Disease Models, Animal |
| Necrosis Antibodies | >19 publications with PGP9.5 and Necrosis |
| Nerve Degeneration Antibodies | >18 publications with PGP9.5 and Nerve Degeneration |
Organs/Tissues associated with anti-PGP9.5 antibody
| Organ/Tissue Name | Pubmed Publications |
|---|---|
| Nerve Antibodies | >173 publications with PGP9.5 and Nerve |
| Brain Antibodies | >106 publications with PGP9.5 and Brain |
| Skin Antibodies | >85 publications with PGP9.5 and Skin |
| Bone Antibodies | >59 publications with PGP9.5 and Bone |
| Lymph Antibodies | >55 publications with PGP9.5 and Lymph |
| Lung Antibodies | >36 publications with PGP9.5 and Lung |
| Mouth Antibodies | >27 publications with PGP9.5 and Mouth |
| Testis Antibodies | >20 publications with PGP9.5 and Testis |
| Uterus Antibodies | >19 publications with PGP9.5 and Uterus |
| Embryonic Tissue Antibodies | >18 publications with PGP9.5 and Embryonic Tissue |