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Phenoxyethanol [122-99-6]

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Référence NB-64-10027-1g

Conditionnement : 1g

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Phenoxyethanol

(Synonyms: NSC-1864, NSC1864, NSC 1864) Copy Product Info

Synonyms: NSC-1864, NSC1864, NSC 1864

Catalog No. T20293 Copy Product Info

Purity: 99.47%

Phenoxyethanol (NSC-1864) is germicidal. It often used together with quaternary ammonium compounds.

Cas No. 122-99-6

For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.47%

Appearance:Liquid

Color:Transparent

Product Information

Phenoxyethanol AI Summary

Phenoxyethanol exhibits a diverse range of bioactivities. It acts as an inhibitor of RecQ-Like DNA Helicase 1 and Aldehyde Dehydrogenase 1 with potencies of 12589.3 nM and 39810.7 nM, respectively. Additionally, it functions as an agonist for retinoid X receptor alpha, androgen receptor, and thyroid hormone receptor beta signaling, showing potencies from 15848.9 nM to 4.0 nM. It also antagonizes androgen receptor and glucocorticoid receptor signaling with potencies of 1000000.0 nM and 0.7 nM respectively. The compound affects cell viability in LYMP2-005 and S16 Schwann cell assays with potencies of 3162.3 nM and 80.9 nM. It activates several pathways, including p53, rat pregnane X receptor, and the fibrous dysplasia/McCune-Albright syndrome pathway, with potencies from 56234.1 nM to 8912.5 nM, and inhibits Polymerase Iota at 79432.8 nM. In antiviral assays, it blocks Ebola Virus entry with AC50 values ranging from 562.3 nM to 7.943 µM. Furthermore, Phenoxyethanol shows antibacterial activity against Staphylococcus aureus MN8, more effectively reducing bacterial activity and inhibiting toxin TSST-1 production at a 0.10% concentration compared to 0.50% after 24 hours..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Phenoxyethanol (NSC-1864) is germicidal. It often used together with quaternary ammonium compounds.
Synonyms	NSC-1864, NSC1864, NSC 1864

Chemical Properties

Molecular Weight	138.1638
Formula	C₈H₁₀O₂
Cas No.	122-99-6
Smiles	OCCOC1=CC=CC=C1
Relative Density.	1.11. Temperature:20 °C.

Storage & Solubility Information

Storage

Pure form: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 250.00 mg/mL (1809.45 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Saline: 10.00 mg/mL (72.38 mM), Solution.

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2.00 mg/mL (14.48 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	7.2378 mL	36.1889 mL	72.3779 mL	361.8893 mL
5 mM	1.4476 mL	7.2378 mL	14.4756 mL	72.3779 mL
10 mM	0.7238 mL	3.6189 mL	7.2378 mL	36.1889 mL
20 mM	0.3619 mL	1.8094 mL	3.6189 mL	18.0945 mL
50 mM	0.1448 mL	0.7238 mL	1.4476 mL	7.2378 mL
100 mM	0.0724 mL	0.3619 mL	0.7238 mL	3.6189 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

Calculator

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

Keywords

vaccineuncouple agenttextilepreservativePhenoxyethanolInhibitorinhibitcosmeticbroad spectrumBacterialantimicrobial

Related Tags: Phenoxyethanol chemical structure | Phenoxyethanol formula | Phenoxyethanol molecular weight