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Réactifs et instruments pour l'immunologie, la biologie cellulaire et la biologie moléculaire.

Phenoxyethanol [122-99-6]

Imprimer

Référence NB-64-10027-1mL

Conditionnement : 1mLx10mM(inDMSO)

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Phenoxyethanol (Synonyms: NSC-1864, NSC1864, NSC 1864)

Catalog No. T20293 Copy Product Info

Purity: 99.47%

Phenoxyethanol (NSC-1864) is germicidal. It often used together with quaternary ammonium compounds.

Phenoxyethanol

Copy Product Info

Synonyms NSC-1864, NSC1864, NSC 1864

Phenoxyethanol (NSC-1864) is germicidal. It often used together with quaternary ammonium compounds.

Cas No. 122-99-6

Batch Information

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Purity:99.47%

Appearance:Liquid

Color:Transparent

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COA HNMR LCMS

Product Introduction

Phenoxyethanol AI Summary

Phenoxyethanol exhibits a diverse range of bioactivities. It acts as an inhibitor of RecQ-Like DNA Helicase 1 and Aldehyde Dehydrogenase 1 with potencies of 12589.3 nM and 39810.7 nM, respectively. Additionally, it functions as an agonist for retinoid X receptor alpha, androgen receptor, and thyroid hormone receptor beta signaling, showing potencies from 15848.9 nM to 4.0 nM. It also antagonizes androgen receptor and glucocorticoid receptor signaling with potencies of 1000000.0 nM and 0.7 nM respectively. The compound affects cell viability in LYMP2-005 and S16 Schwann cell assays with potencies of 3162.3 nM and 80.9 nM. It activates several pathways, including p53, rat pregnane X receptor, and the fibrous dysplasia/McCune-Albright syndrome pathway, with potencies from 56234.1 nM to 8912.5 nM, and inhibits Polymerase Iota at 79432.8 nM. In antiviral assays, it blocks Ebola Virus entry with AC50 values ranging from 562.3 nM to 7.943 µM. Furthermore, Phenoxyethanol shows antibacterial activity against Staphylococcus aureus MN8, more effectively reducing bacterial activity and inhibiting toxin TSST-1 production at a 0.10% concentration compared to 0.50% after 24 hours..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Phenoxyethanol (NSC-1864) is germicidal. It often used together with quaternary ammonium compounds.
Synonyms	NSC-1864, NSC1864, NSC 1864

Chemical Properties

Molecular Weight	138.16
Formula	C₈H₁₀O₂
Cas No.	122-99-6
Smiles	OCCOC=1C=CC=CC1
Relative Density.	1.11. Temperature:20 °C.

Storage & Solubility Information

Storage

Pure form: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (398.09 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (14.48 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	7.2380 mL	36.1899 mL	72.3798 mL	361.8992 mL
5 mM	1.4476 mL	7.2380 mL	14.4760 mL	72.3798 mL
10 mM	0.7238 mL	3.6190 mL	7.2380 mL	36.1899 mL
20 mM	0.3619 mL	1.8095 mL	3.6190 mL	18.0950 mL
50 mM	0.1448 mL	0.7238 mL	1.4476 mL	7.2380 mL
100 mM	0.0724 mL	0.3619 mL	0.7238 mL	3.6190 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.