Réactifs et instruments pour l'immunologie, la biologie cellulaire et la biologie moléculaire.
 
> Polymyxin B [1404-26-8]

Polymyxin B [1404-26-8]

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Référence orb1944475-50mg

Conditionnement : 50mg

Marque : Biorbyt

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Polymyxin B [[1404-26-8]]

Polymyxin B

SKU: orb1944475

Description

Polymyxin B is a polymyxin-class antibiotic that disrupts Gram-negative bacterial membranes by binding to lipopolysaccharide (LPS). It is a critical research tool for studying extensively drug-resistant (XDR) Gram-negative infections and endotoxemia in both in vitro and in vivo experimental models.

Research Area

Infectious Disease & Virology

Images & Validation

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Polymyxin B

Key Properties

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CAS Number1404-26-8
Purity91.00% (May vary between batches)
TargetAntibacterial,Antibiotic
SolubilityH2O:16.67 mg/mL

Bioactivity

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In Vivo
Polymyxin B was administered intravenously once daily for seven consecutive days at a dose range of 5-20 mg/kg Polymyxin B. The treatment of PBMCs with Polymyxin B for six hours reduced TNF-α and IL-10 production. A nephrotoxicity endpoint was observed in the Sprague-Dawley rat model at the 20 mg/kg dose, whereas no such endpoint was observed at the 5 mg/kg dose.
In Vitro
10 μg/mL Polymyxin B, treated for 6 hours, reduced TNF-α and IL-10 production in human peripheral blood mononuclear cells (PBMCs).

Storage & Handling

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Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

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Antibiotic, Bacterial
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Quick Database Links

Gene Symbol
Antibacterial,Antibiotic

Protocol Information