Recombinant Collagen Type VI Alpha 1 (COL6a1)
Référence MBS2009059-0,1mg
Conditionnement : 0.1mg
Marque : MyBiosource
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SDS-PAGE
Collagen Type VI Alpha 1 (COL6a1) Mus Musculus (Mouse) Recombinant Protein
For Research Use Only. Not for use in diagnostic procedures. Special Promotion Catalog #: MBS2009059SPECIAL PROMOTION: Get FREE Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment
MBS2009059 is a recombinant protein targeting COL6a1. Also known as Recombinant Collagen Type VI Alpha 1 (COL6a1). Reactive in Mus musculus (Mouse). Host: E.coli. More details
Product Overview
Online Datasheet in PDFProduct Name
Collagen Type VI Alpha 1 (COL6a1), Recombinant Protein
Full Product Name
Recombinant Collagen Type VI Alpha 1 (COL6a1)
Product Gene Name
COL6a1 recombinant protein
Sequence
NLVWNAGAL HYSDEVEIIR GLTRMPSGRD ELKASVDAVK YFGKGTYTDC AIKKGLEELL IGGSHLKENK YLIVVTDGHP LEGYKEPCGG LEDAVNEAKH LGIKVFSVAI TPDHLEPRLS IIATDHTYRR NF
Host
E.coli
Species Reactivity
Mus musculus (Mouse)
Form/Format
PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
Purity/Purification
> 97%
Concentration
Original Concentration: 120ug/mL (lot specific)
Preparation and Storage
Storage:
Avoid repeated freeze/thaw cycles.
Store at 2-8 degree C for one month.
Aliquot and store at -80 degree C for 12 months.
Stability Test:
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
Avoid repeated freeze/thaw cycles.
Store at 2-8 degree C for one month.
Aliquot and store at -80 degree C for 12 months.
Stability Test:
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
Matching Pairs
Unconjugated Antibody: COL6a1 (MBS2004192)
Immunogen: COL6a1 (MBS2009059)
Immunogen: COL6a1 (MBS2009059)
Matching Pairs
APC-CY7 Conjugated Antibody: COL6a1 (MBS2063616)
Immunogen: COL6a1 (MBS2009059)
Immunogen: COL6a1 (MBS2009059)
Molecular Weight
Predicted Molecular Mass: 15.8kDa
Accurate Molecular Mass: 16kDa as determined by SDS-PAGE reducing conditions.
Accurate Molecular Mass: 16kDa as determined by SDS-PAGE reducing conditions.
Chromosome Location
Chromosome: 10; NC_000076.6 (76708792..76726044, complement). Location: 10 B5-C1; 10 39.71 cM
Supply Chain Verification
Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.
Source
Prokaryotic expression
Residues
Asn82~Phe212
Tags
N-terminal His Tag
Subcellular Location
Extracellular matrix
Traits
Freeze-dried powder
Predicted isoelectric point
6.3
Usage
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
ISO Certification
Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.
Applications Tested/Suitable for COL6a1 recombinant protein
Positive Control; Immunogen; SDS-PAGE; Western Blot (WB).
Application Notes for COL6a1 recombinant protein
(May be suitable for use in other assays to be determined by the end user.)
Other Notes
Small volumes of COL6a1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Additional Details
NCBI/Uniprot data below describe general gene information for COL6a1. It may not necessarily be applicable to this product.
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
collagen alpha-1(VI) chain
NCBI Official Synonym Full Names
collagen, type VI, alpha 1
NCBI Official Symbol
Col6a1
NCBI Official Synonym Symbols
Col6a-1; AI747156
UniProt Protein Name
Collagen alpha-1(VI) chain
Protein Family
Collagen
UniProt Gene Name
Col6a1
UniProt Entry Name
CO6A1_MOUSE
NCBI Protein Information
collagen alpha-1(VI) chain; collagen alpha-1(VI) chain; procollagen, type VI, alpha 1
UniProt Comments for COL6a1
COL6A1: Collagen VI acts as a cell-binding protein. Defects in COL6A1 are a cause of Bethlem myopathy (BM). BM is a rare autosomal dominant proximal myopathy characterized by early childhood onset (complete penetrance by the age of 5) and joint contractures most frequently affecting the elbows and ankles. Defects in COL6A1 are a cause of Ullrich congenital muscular dystrophy (UCMD); also known as Ullrich scleroatonic muscular dystrophy. UCMD is an autosomal recessive congenital myopathy characterized by muscle weakness and multiple joint contractures, generally noted at birth or early infancy. The clinical course is more severe than in Bethlem myopathy. Belongs to the type VI collagen family.
Protein type: Extracellular matrix; Secreted, signal peptide; Secreted
Cellular Component: extracellular matrix; proteinaceous extracellular matrix; collagen; protein complex; membrane; lysosomal membrane; extracellular region; sarcolemma
Molecular Function: platelet-derived growth factor binding
Biological Process: osteoblast differentiation; cell adhesion
Show more Protein type: Extracellular matrix; Secreted, signal peptide; Secreted
Cellular Component: extracellular matrix; proteinaceous extracellular matrix; collagen; protein complex; membrane; lysosomal membrane; extracellular region; sarcolemma
Molecular Function: platelet-derived growth factor binding
Biological Process: osteoblast differentiation; cell adhesion
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Product Note
Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.
Product PubMed Publications
Products associated with COL6a1 recombinant protein
| Reference Product | PubMed Publications |
|---|---|
| Col6a2 recombinant protein | >69 publications with COL6a1 and Col6a2 |
| Col3a1 recombinant protein | >11 publications with COL6a1 and Col3a1 |
| Col1a1 recombinant protein | >9 publications with COL6a1 and Col1a1 |
| Col5a1 recombinant protein | >5 publications with COL6a1 and Col5a1 |
| Col1a2 recombinant protein | >5 publications with COL6a1 and Col1a2 |
| Col5a2 recombinant protein | >5 publications with COL6a1 and Col5a2 |
| Col2a1 recombinant protein | >3 publications with COL6a1 and Col2a1 |
| Col4a2 recombinant protein | >1 publications with COL6a1 and Col4a2 |
| Col4a4 recombinant protein | >1 publications with COL6a1 and Col4a4 |
| Col15a1 recombinant protein | >1 publications with COL6a1 and Col15a1 |
Pathways associated with COL6a1 recombinant protein
| Products by Pathway | Pathway Diagram |
|---|---|
| Assembly Of Collagen Fibrils And Other Multimeric Structures Pathway antibodies | Assembly Of Collagen Fibrils And Other Multimeric Structures Pathway Diagram |
| Axon Guidance Pathway antibodies | Axon Guidance Pathway Diagram |
| Collagen Biosynthesis And Modifying Enzymes Pathway antibodies | Collagen Biosynthesis And Modifying Enzymes Pathway Diagram |
| Collagen Formation Pathway antibodies | Collagen Formation Pathway Diagram |
| Developmental Biology Pathway antibodies | Developmental Biology Pathway Diagram |
| ECM-receptor Interaction Pathway antibodies | ECM-receptor Interaction Pathway Diagram |
| ECM-receptor Interaction Pathway antibodies | ECM-receptor Interaction Pathway Diagram |
| Extracellular Matrix Organization Pathway antibodies | Extracellular Matrix Organization Pathway Diagram |
| Focal Adhesion Pathway antibodies | Focal Adhesion Pathway Diagram |
| Focal Adhesion Pathway antibodies | Focal Adhesion Pathway Diagram |
Diseases associated with COL6a1 recombinant protein
| Disease Name | Pubmed Publications |
|---|---|
| Nervous System Diseases Antibodies | >83 publications with COL6a1 and Nervous System Diseases |
| Bethlem myopathy Antibodies | >57 publications with COL6a1 and Bethlem myopathy |
| Muscular Dystrophies Antibodies | >51 publications with COL6a1 and Muscular Dystrophies |
| Neoplasms Antibodies | >13 publications with COL6a1 and Neoplasms |
| Disease Models, Animal Antibodies | >13 publications with COL6a1 and Disease Models, Animal |
| Scleroatonic muscular dystrophy Antibodies | >7 publications with COL6a1 and Scleroatonic muscular dystrophy |
| Brain Diseases Antibodies | >6 publications with COL6a1 and Brain Diseases |
| Inflammation Antibodies | >5 publications with COL6a1 and Inflammation |
| Heart Defects, Congenital Antibodies | >5 publications with COL6a1 and Heart Defects, Congenital |
| Fibrosis Antibodies | >5 publications with COL6a1 and Fibrosis |
Organs/Tissues associated with COL6a1 recombinant protein
| Organ/Tissue Name | Pubmed Publications |
|---|---|
| Muscle Antibodies | >65 publications with COL6a1 and Muscle |
| Joint Antibodies | >32 publications with COL6a1 and Joint |
| Skin Antibodies | >22 publications with COL6a1 and Skin |
| Connective Tissue Antibodies | >16 publications with COL6a1 and Connective Tissue |
| Bone Antibodies | >14 publications with COL6a1 and Bone |
| Heart Antibodies | >9 publications with COL6a1 and Heart |
| Adipose Tissue Antibodies | >7 publications with COL6a1 and Adipose Tissue |
| Lung Antibodies | >7 publications with COL6a1 and Lung |
| Kidney Antibodies | >3 publications with COL6a1 and Kidney |
| Embryonic Tissue Antibodies | >3 publications with COL6a1 and Embryonic Tissue |
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