Recombinant Cytoskeleton Associated Protein 4 (CKAP4)
Référence MBS2123959-0,1mg
Conditionnement : 0.1mg
Marque : MyBiosource
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Cytoskeleton Associated Protein 4 (CKAP4) Homo Sapiens (Human) Recombinant Protein
For Research Use Only. Not for use in diagnostic procedures. Special Promotion Catalog #: MBS2123959SPECIAL PROMOTION: Get FREE Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment
MBS2123959 is a recombinant protein targeting CKAP4. Also known as Recombinant Cytoskeleton Associated Protein 4 (CKAP4). Reactive in Homo sapiens (Human). Host: E.coli. More details
Product Overview
Online Datasheet in PDFProduct Name
Cytoskeleton Associated Protein 4 (CKAP4), Recombinant Protein
Full Product Name
Recombinant Cytoskeleton Associated Protein 4 (CKAP4)
Product Gene Name
CKAP4 recombinant protein
Product Synonym Names
P63; CLIMP-63; ERGIC-63; 63-kDa cytoskeleton-linking membrane protein
Host
E.coli
Species Reactivity
Homo sapiens (Human)
Form/Format
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
Purity/Purification
> 90%
Concentration
Original Concentration: 200ug/mL (lot specific)
Preparation and Storage
Storage:
Avoid repeated freeze/thaw cycles.
Store at 2-8 degree C for one month.
Aliquot and store at -80 degree C for 12 months.
Stability Test:
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
Avoid repeated freeze/thaw cycles.
Store at 2-8 degree C for one month.
Aliquot and store at -80 degree C for 12 months.
Stability Test:
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
Molecular Weight
Predicted Molecular Mass: 57.7kDa
Accurate Molecular Mass: 58kDa as determined by SDS-PAGE reducing conditions.
Accurate Molecular Mass: 58kDa as determined by SDS-PAGE reducing conditions.
OMIM
606779
Supply Chain Verification
Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.
Source
Prokaryotic expression
Residues
His128~Val602
Tags
N-terminal His Tag
Subcellular Location
Membrane, Endoplasmic reticulum lumen
Traits
Freeze-dried powder
Predicted isoelectric point
4.7
Usage
Reconstitute in 10mM PBS (pH7.4) to a concentration of 0.1-1.0 mg/mL. Do not vortex.
Product Categories/Family for CKAP4 recombinant protein
Cytokine
ISO Certification
Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.
Applications Tested/Suitable for CKAP4 recombinant protein
Positive Control; Immunogen; SDS-PAGE; Western Blot (WB).
Application Notes for CKAP4 recombinant protein
(May be suitable for use in other assays to be determined by the end user.)
Other Notes
Small volumes of CKAP4 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Additional Details
NCBI/Uniprot data below describe general gene information for CKAP4. It may not necessarily be applicable to this product.
NCBI Official Full Name
SSH2 protein
NCBI Official Synonym Full Names
slingshot protein phosphatase 2
NCBI Official Symbol
SSH2
NCBI Official Synonym Symbols
SSH-2; SSH-2L
UniProt Protein Name
Protein phosphatase Slingshot homolog 2
UniProt Synonym Protein Names
SSH-like protein 2
Protein Family
Cytoskeleton-associated protein
UniProt Gene Name
SSH2
UniProt Synonym Gene Names
KIAA1725; SSH2L; SSH-2L; hSSH-2L
UniProt Entry Name
SSH2_HUMAN
NCBI Protein Information
protein phosphatase Slingshot homolog 2
NCBI Summary for CKAP4
This gene encodes a protein tyrosine phosphatase that plays a key role in the regulation of actin filaments. The encoded protein dephosphorylates and activates cofilin, which promotes actin filament depolymerization. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
Show more UniProt Comments for CKAP4
SSH2: Protein phosphatase which regulates actin filament dynamics. Dephosphorylates and activates the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Inhibitory phosphorylation of cofilin is mediated by LIMK1, which may also be dephosphorylated and inactivated by this protein. Belongs to the protein-tyrosine phosphatase family. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Actin-binding; EC 3.1.3.16; EC 3.1.3.48; Protein phosphatase, dual-specificity
Chromosomal Location of Human Ortholog: 17q11.2
Cellular Component: extracellular space; cytoskeleton; cytoplasm
Molecular Function: DNA binding; protein tyrosine/serine/threonine phosphatase activity; protein tyrosine phosphatase activity; actin binding; phosphoprotein phosphatase activity
Biological Process: regulation of actin polymerization and/or depolymerization; protein amino acid dephosphorylation; regulation of axonogenesis; actin cytoskeleton organization and biogenesis
Show more Protein type: Actin-binding; EC 3.1.3.16; EC 3.1.3.48; Protein phosphatase, dual-specificity
Chromosomal Location of Human Ortholog: 17q11.2
Cellular Component: extracellular space; cytoskeleton; cytoplasm
Molecular Function: DNA binding; protein tyrosine/serine/threonine phosphatase activity; protein tyrosine phosphatase activity; actin binding; phosphoprotein phosphatase activity
Biological Process: regulation of actin polymerization and/or depolymerization; protein amino acid dephosphorylation; regulation of axonogenesis; actin cytoskeleton organization and biogenesis
Research Articles on CKAP4
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Product Note
Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.
Product PubMed Publications
Products associated with CKAP4 recombinant protein
| Reference Product | PubMed Publications |
|---|---|
| LIMK1 recombinant protein | >2 publications with CKAP4 and LIMK1 |
Pathways associated with CKAP4 recombinant protein
| Products by Pathway | Pathway Diagram |
|---|---|
| Regulation Of Actin Cytoskeleton Pathway antibodies | Regulation Of Actin Cytoskeleton Pathway Diagram |
| Regulation Of Actin Cytoskeleton Pathway antibodies | Regulation Of Actin Cytoskeleton Pathway Diagram |
| Regulation Of Actin Cytoskeleton Pathway antibodies | Regulation Of Actin Cytoskeleton Pathway Diagram |
Diseases associated with CKAP4 recombinant protein
| Disease Name | Pubmed Publications |
|---|---|
| Neoplasms Antibodies | >3 publications with CKAP4 and Neoplasms |
| Liver Neoplasms Antibodies | >1 publications with CKAP4 and Liver Neoplasms |
| Death Antibodies | >1 publications with CKAP4 and Death |
| Kidney Diseases Antibodies | >1 publications with CKAP4 and Kidney Diseases |
| Carcinoma, Hepatocellular Antibodies | >1 publications with CKAP4 and Carcinoma, Hepatocellular |
| Liver Diseases Antibodies | >1 publications with CKAP4 and Liver Diseases |
Organs/Tissues associated with CKAP4 recombinant protein
| Organ/Tissue Name | Pubmed Publications |
|---|---|
| Ascites Antibodies | >1 publications with CKAP4 and Ascites |
| Muscle Antibodies | >1 publications with CKAP4 and Muscle |
| Stomach Antibodies | >1 publications with CKAP4 and Stomach |
| Lung Antibodies | >1 publications with CKAP4 and Lung |
| Thyroid Antibodies | >1 publications with CKAP4 and Thyroid |
| Kidney Antibodies | >1 publications with CKAP4 and Kidney |