Syntaxin 1A Antibody
Référence MBS8582885-0,1mL-PE
Conditionnement : 0.1mL(PE)
Marque : MyBiosource
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Syntaxin 1a (STX1A) Antibody – Rabbit Polyclonal
For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS8582885MBS8582885 is an antibody targeting STX1A. Also known as Syntaxin 1A Antibody. Reactive in Human, Mouse, Rat, Bovine, Monkey. Host: Rabbit. Rabbit polyclonal antibody to Syntaxin 1A More details
Product Overview
Online Datasheet in PDFProduct Name
Syntaxin 1A (STX1A), Polyclonal Antibody
Full Product Name
Syntaxin 1A Antibody
Product Gene Name
anti-STX1A antibody
Product Synonym Names
STX1; Syntaxin-1A; Neuron-specific antigen HPC-1
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat, Bovine, Monkey
Form/Format
Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH7.3, 30% glycerol, and 0.01% sodium azide.
Purity/Purification
The antibody was purified by immunogen affinity chromatography.
Specificity
Recognizes endogenous levels of Syntaxin 1A protein.
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.
Molecular Weight
33,023 Da
Chromosome Location
Chromosome: 7; NC_000007.13 (73113535..73134017, complement). Location: 7q11.23
OMIM
186590
Immunogen
KLH-conjugated synthetic peptide encompassing a sequence within the center region of human Syntaxin 1A. The exact sequence is proprietary.
Product Categories/Family for anti-STX1A antibody
Primary Antibody
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-STX1A antibody
Western Blot (WB)
Application Notes for anti-STX1A antibody
WB: 1:500-1:1000
Other Notes
Small volumes of anti-STX1A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Additional Details
NCBI/Uniprot data below describe general gene information for STX1A. It may not necessarily be applicable to this product.
NCBI Official Full Name
syntaxin-1A isoform 2
NCBI Official Synonym Full Names
syntaxin 1A (brain)
NCBI Official Symbol
STX1A
NCBI Official Synonym Symbols
STX1; HPC-1; P35-1; SYN1A
UniProt Protein Name
Syntaxin-1A
UniProt Synonym Protein Names
Neuron-specific antigen HPC-1
Protein Family
Syntaxin
UniProt Gene Name
STX1A
UniProt Synonym Gene Names
STX1
UniProt Entry Name
STX1A_HUMAN
NCBI Protein Information
syntaxin-1A; neuron-specific antigen HPC-1
NCBI Summary for STX1A
This gene encodes a member of the syntaxin superfamily. Syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane. Syntaxins possess a single C-terminal transmembrane domain, a SNARE [Soluble NSF (N-ethylmaleimide-sensitive fusion protein)-Attachment protein REceptor] domain (known as H3), and an N-terminal regulatory domain (Habc). Syntaxins bind synaptotagmin in a calcium-dependent fashion and interact with voltage dependent calcium and potassium channels via the C-terminal H3 domain. This gene product is a key molecule in ion channel regulation and synaptic exocytosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009]
Show more UniProt Comments for STX1A
STX1A: a type IV membrane protein involved in docking of synaptic vesicles at presynaptic active zones. May play a critical role in neurotransmitter exocytosis. Part of the SNARE core complex containing SNAP25, VAMP2 and STX1A. Three splice variant isoforms have been described.
Protein type: Vesicle; Membrane protein, integral
Chromosomal Location of Human Ortholog: 7q11.23
Cellular Component: SNARE complex; synaptic vesicle; neuron projection; synaptic vesicle membrane; extracellular region; plasma membrane; integral to membrane; endomembrane system; actomyosin; cytosol; cell junction; secretory granule
Molecular Function: protein binding, bridging; SNAP receptor activity; protein domain specific binding; myosin binding; protein N-terminus binding; calcium-dependent protein binding; ATP-dependent protein binding; SNARE binding; protein binding; chloride channel inhibitor activity; protein heterodimerization activity; myosin head/neck binding; calcium channel inhibitor activity; glycoprotein binding; kinase binding
Biological Process: response to gravity; neurotransmitter secretion; pathogenesis; positive regulation of neurotransmitter secretion; calcium ion-dependent exocytosis; synaptic vesicle fusion to presynaptic membrane; intracellular protein transport; synaptic transmission; vesicle docking; cellular protein metabolic process; glutamate secretion; energy reserve metabolic process; regulation of insulin secretion; secretion by cell; synaptic vesicle docking during exocytosis; positive regulation of exocytosis
Show more Protein type: Vesicle; Membrane protein, integral
Chromosomal Location of Human Ortholog: 7q11.23
Cellular Component: SNARE complex; synaptic vesicle; neuron projection; synaptic vesicle membrane; extracellular region; plasma membrane; integral to membrane; endomembrane system; actomyosin; cytosol; cell junction; secretory granule
Molecular Function: protein binding, bridging; SNAP receptor activity; protein domain specific binding; myosin binding; protein N-terminus binding; calcium-dependent protein binding; ATP-dependent protein binding; SNARE binding; protein binding; chloride channel inhibitor activity; protein heterodimerization activity; myosin head/neck binding; calcium channel inhibitor activity; glycoprotein binding; kinase binding
Biological Process: response to gravity; neurotransmitter secretion; pathogenesis; positive regulation of neurotransmitter secretion; calcium ion-dependent exocytosis; synaptic vesicle fusion to presynaptic membrane; intracellular protein transport; synaptic transmission; vesicle docking; cellular protein metabolic process; glutamate secretion; energy reserve metabolic process; regulation of insulin secretion; secretion by cell; synaptic vesicle docking during exocytosis; positive regulation of exocytosis
Research Articles on STX1A
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Product Note
Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.
Product PubMed Publications
Products associated with anti-STX1A antibody
| Reference Product | PubMed Publications |
|---|---|
| SNAP25 antibody | >97 publications with STX1A and SNAP25 |
| VAMP2 antibody | >30 publications with STX1A and VAMP2 |
| NSF antibody | >25 publications with STX1A and NSF |
| STXBP1 antibody | >21 publications with STX1A and STXBP1 |
| SNAP23 antibody | >16 publications with STX1A and SNAP23 |
| CFTR antibody | >14 publications with STX1A and CFTR |
| SYT1 antibody | >13 publications with STX1A and SYT1 |
| STXBP2 antibody | >7 publications with STX1A and STXBP2 |
| SLC6A1 antibody | >7 publications with STX1A and SLC6A1 |
| VAMP8 antibody | >6 publications with STX1A and VAMP8 |
Pathways associated with anti-STX1A antibody
| Products by Pathway | Pathway Diagram |
|---|---|
| Acetylcholine Neurotransmitter Release Cycle Pathway antibodies | Acetylcholine Neurotransmitter Release Cycle Pathway Diagram |
| Amphetamine Addiction Pathway antibodies | Amphetamine Addiction Pathway Diagram |
| Amphetamine Addiction Pathway antibodies | Amphetamine Addiction Pathway Diagram |
| Botulinum Neurotoxicity Pathway antibodies | Botulinum Neurotoxicity Pathway Diagram |
| Disease Pathway antibodies | Disease Pathway Diagram |
| Dopamine Neurotransmitter Release Cycle Pathway antibodies | Dopamine Neurotransmitter Release Cycle Pathway Diagram |
| Effects Of Botulinum Toxin Pathway antibodies | Effects Of Botulinum Toxin Pathway Diagram |
| GABA Synthesis, Release, Reuptake And Degradation Pathway antibodies | GABA Synthesis, Release, Reuptake And Degradation Pathway Diagram |
| Glutamate Neurotransmitter Release Cycle Pathway antibodies | Glutamate Neurotransmitter Release Cycle Pathway Diagram |
| Insulin Processing Pathway antibodies | Insulin Processing Pathway Diagram |
Diseases associated with anti-STX1A antibody
| Disease Name | Pubmed Publications |
|---|---|
| Fibrosis Antibodies | >14 publications with STX1A and Fibrosis |
| Neurobehavioral Manifestations Antibodies | >14 publications with STX1A and Neurobehavioral Manifestations |
| Cardiovascular Diseases Antibodies | >13 publications with STX1A and Cardiovascular Diseases |
| Neoplasms Antibodies | >11 publications with STX1A and Neoplasms |
| Heart Diseases Antibodies | >11 publications with STX1A and Heart Diseases |
| Brain Diseases Antibodies | >9 publications with STX1A and Brain Diseases |
| Drug Toxicity Antibodies | >6 publications with STX1A and Drug Toxicity |
| Movement Disorders Antibodies | >2 publications with STX1A and Movement Disorders |
| Cognition Disorders Antibodies | >2 publications with STX1A and Cognition Disorders |
| Learning Disorders Antibodies | >2 publications with STX1A and Learning Disorders |
Organs/Tissues associated with anti-STX1A antibody
| Organ/Tissue Name | Pubmed Publications |
|---|---|
| Nerve Antibodies | >287 publications with STX1A and Nerve |
| Brain Antibodies | >146 publications with STX1A and Brain |
| Pancreas Antibodies | >34 publications with STX1A and Pancreas |
| Embryonic Tissue Antibodies | >28 publications with STX1A and Embryonic Tissue |
| Kidney Antibodies | >21 publications with STX1A and Kidney |
| Muscle Antibodies | >18 publications with STX1A and Muscle |
| Eye Antibodies | >13 publications with STX1A and Eye |
| Lung Antibodies | >9 publications with STX1A and Lung |
| Ganglia Antibodies | >6 publications with STX1A and Ganglia |
| Mouth Antibodies | >6 publications with STX1A and Mouth |