Tauroursodeoxycholate sodium [35807-85-3]
Référence T6993-1ml
Conditionnement : 1mLx10mM(inDMSO)
Marque : TargetMol
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Tauroursodeoxycholate sodium
(Synonyms: TUDC, Tauroursodeoxycholic acid sodium salt, Sodium Tauroursodeoxycholate (TUDC), Sodium tauroursodeoxycholate) Copy Product Info
Tauroursodeoxycholate sodium (TUDC) is an endoplasmic reticulum (ER) stress inhibitor, used for the treatment of gallstones and liver cirrhosis.
Cas No. 35807-85-3
For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:97.90%
Appearance:Solid
Color:White
COA LCMS HPLC HNMR
Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Tauroursodeoxycholate sodium (TUDC) is an endoplasmic reticulum (ER) stress inhibitor, used for the treatment of gallstones and liver cirrhosis. |
| In vivo | In phalloidin-induced cholestasis rats, Tauroursodeoxycholate (360 μmol/kg, i.v.) significantly suppresses the decrease in bile flow and increases in serum alkaline phosphatase, leucine aminopeptidase and glutamic pyruvic transaminase activities, cholesterol, phospholipid and bile acid concentrations. [2] |
| Synonyms | TUDC, Tauroursodeoxycholic acid sodium salt, Sodium Tauroursodeoxycholate (TUDC), Sodium tauroursodeoxycholate |
| Cell Research | Cell lines: Mz-ChA-1 cells. Concentrations: ~200 μM. Method: After trypsinization,Mz-ChA-1 cells are suspended in CCM at 5×104 cells/mL,and 200 μL of the cell suspension is seeded into 96-well plates.After an initial incubation step of 4 h at 37°C in a 5% CO2 incubator,the cells are incubated at 37°C with TUDCA (0.2–200 μM).After incubation for 24–96 h,[3H]thymidine is put into each well at 5.0 μCi/mL and incubated for additional 4 h.[3H]thymidine incorporation is measured by a scintillation counter. |
| Animal Research | Animal Models: Phalloidin-induced cholestasis ratsFormulation & . Dosages: Saline; 360 μMol/kg. Administration: intravenous injection |
| Molecular Weight | 521.69 |
| Formula | C26H44NNaO6S |
| Cas No. | 35807-85-3 |
| Smiles | [Na+].CC(CCC(=O)NCCS([O-])(=O)=O)C1CCC2C3C(O)CC4CC(O)CCC4(C)C3CCC12C |
| Relative Density. | no data available |
| Storage | Keep away from moisture Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||||||||||||||||||||||
| Solubility Information | Ethanol: 10 mg/mL (19.17 mM), Sonication is recommended. DMSO: 257.5 mg/mL (493.59 mM), Sonication is recommended.  H2O: 92 mg/mL (176.35 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||||||||||||
| In Vivo Formulation | 10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (3.83 mM), Sonication is recommended. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | ||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||||||||||||
Ethanol/H2O/DMSO
H2O/DMSO
Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density. | |||||||||||||||||||||||||||||||||||||||||