TBXT/T/Brachyury Rabbit anti-Human Recombinant Monoclonal (RBT-TBXT) Antibody
Référence MBS2403805-0,05mL
Conditionnement : 0.05mL
Marque : MyBiosource
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TBXT Antibody – Rabbit Monoclonal
For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS2403805Brachyury antibody is an unconjugated rabbit recombinant monoclonal antibody to human Brachyury (TBXT/T). Validated for IHC.T-box transcription factor T (TBXT, T brachyury transcription factor, protein T) is a nuclear transcription factor that is involved in… More details
Product Overview
Product Name
TBXT/T/Brachyury, Monoclonal Antibody
Full Product Name
TBXT/T/Brachyury Rabbit anti-Human Recombinant Monoclonal (RBT-TBXT) Antibody
Product Gene Name
anti-TBXT antibody
Product Synonym Names
PathPlus TBXT/T/Brachyury Antibody (clone RBT-TBXT); TBXT; Brachyury; Brachyury protein; Protein T; TFT; T; T brachyury (mouse) homolog; T brachyury homolog; T; brachyury homolog (mouse)
Clonality
Monoclonal
Isotype
IgG
Clone Number
RBT-TBXT
Host
Rabbit
Species Reactivity
Human
Form/Format
Filter sterilized and diluted in buffer, pH7.5, BSA, Sodium Azide
Preparation and Storage
Store at 2-8 degree C. Avoid freeze/thaw cycles.
Applications Tested/Suitable for anti-TBXT antibody
Immunohistochemistry-Paraffin (IHC-P)
Product References and Citations for anti-TBXT antibody
Clin Cancer Res. 2007;13(8):2471-2478. doi: 10.1158/1078-0432.CCR-06-2353; Clin Cancer Res. 2012;18(14):3868-3879. doi: 10.1158/1078-0432.CCR-11-3211; Dis Markers. 2014;2014:514753. doi: 10.1155/2014/514753; Mod Pathol. 2011;24(3):425-429. doi: 10.1038/modpathol.2010.196; Ann Surg Oncol. 2013;20 Suppl 3:S509-S516. doi: 10.1245/s10434-013-2914-9; J Natl Cancer Inst. 2014;106(5): pii: dju054. doi: 10.1093/jnci/dju054; Gastric Cancer. 2016;19(2):651-659. doi: 10.1007/s10120-015-0505-0.
Other Notes
Small volumes of anti-TBXT antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Searchable Terms for TBXT purchase
MBS2403805 is an antibody targeting TBXT. Also known as TBXT/T/Brachyury Rabbit anti-Human Recombinant Monoclonal (RBT-TBXT) Antibody. Reactive in Human. Host: Rabbit.
Additional Details
NCBI/Uniprot data below describe general gene information for TBXT. It may not necessarily be applicable to this product.
NCBI Official Full Name
brachyury protein isoform 1
NCBI Official Synonym Full Names
T brachyury transcription factor
NCBI Official Symbol
T
NCBI Official Synonym Symbols
TFT; SAVA
UniProt Protein Name
Brachyury protein
UniProt Synonym Protein Names
Protein T
Protein Family
T-box-containing protein
UniProt Gene Name
T
UniProt Entry Name
BRAC_HUMAN
NCBI Protein Information
brachyury protein
NCBI Summary for TBXT
The protein encoded by this gene is an embryonic nuclear transcription factor that binds to a specific DNA element, the palindromic T-site. It binds through a region in its N-terminus, called the T-box, and effects transcription of genes required for mesoderm formation and differentiation. The protein is localized to notochord-derived cells. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2012]
Show more UniProt Comments for TBXT
Brachyury: Involved in the transcriptional regulation of genes required for mesoderm formation and differentiation. Binds to a palindromic site (called T site) and activates gene transcription when bound to such a site. Genetic variations in T are associated with susceptibility to neural tube defects (NTD). NTD are common congenital malformations. Spina bifida, which results from malformations in the caudal region of the neural tube, is compatible with life but associated with significant morbidity, including lower limb paralysis. T is involved in susceptibility to the development of chordoma (CHDM). Chordomas are rare, clinically malignant tumors derived from notochordal remnants. They occur along the length of the spinal axis, predominantly in the sphenooccipital, vertebral and sacrococcygeal regions. They are characterized by slow growth, local destruction of bone, extension into adjacent soft tissues and rarely, distant metastatic spread. Susceptibility to development of chordomas is due to a T gene duplication.
Protein type: Motility/polarity/chemotaxis; DNA-binding; Cell cycle regulation; Transcription factor
Chromosomal Location of Human Ortholog: 6q27
Cellular Component: cytoplasm; nuclear chromatin; nucleus
Molecular Function: RNA polymerase II transcription factor activity, enhancer binding; transcription factor activity
Biological Process: transcription from RNA polymerase II promoter; heart morphogenesis; somitogenesis; neural plate morphogenesis; embryonic skeletal development; mesoderm migration; notochord formation; negative regulation of transcription from RNA polymerase II promoter; Wnt receptor signaling pathway through beta-catenin; signal transduction; BMP signaling pathway; determination of anterior/posterior axis, embryo; positive regulation of cell proliferation; neural tube closure; penetration of zona pellucida; mesoderm development; vasculogenesis
Disease: Neural Tube Defects; Sacral Agenesis With Vertebral Anomalies
Show more Protein type: Motility/polarity/chemotaxis; DNA-binding; Cell cycle regulation; Transcription factor
Chromosomal Location of Human Ortholog: 6q27
Cellular Component: cytoplasm; nuclear chromatin; nucleus
Molecular Function: RNA polymerase II transcription factor activity, enhancer binding; transcription factor activity
Biological Process: transcription from RNA polymerase II promoter; heart morphogenesis; somitogenesis; neural plate morphogenesis; embryonic skeletal development; mesoderm migration; notochord formation; negative regulation of transcription from RNA polymerase II promoter; Wnt receptor signaling pathway through beta-catenin; signal transduction; BMP signaling pathway; determination of anterior/posterior axis, embryo; positive regulation of cell proliferation; neural tube closure; penetration of zona pellucida; mesoderm development; vasculogenesis
Disease: Neural Tube Defects; Sacral Agenesis With Vertebral Anomalies
Research Articles on TBXT
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Product Note
Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.
Product PubMed Publications
Pathways associated with anti-TBXT antibody
| Products by Pathway | Pathway Diagram |
|---|---|
| Cardiac Progenitor Differentiation Pathway antibodies | Cardiac Progenitor Differentiation Pathway Diagram |
| Regulation Of Wnt-mediated Beta Catenin Signaling And Target Gene Transcription Pathway antibodies | Regulation Of Wnt-mediated Beta Catenin Signaling And Target Gene Transcription Pathway Diagram |
Diseases associated with anti-TBXT antibody
| Disease Name | Pubmed Publications |
|---|---|
| Anemia Antibodies | >1 publications with TBXT and Anemia |
Organs/Tissues associated with anti-TBXT antibody
| Organ/Tissue Name | Pubmed Publications |
|---|---|
| Connective Tissue Antibodies | >1 publications with TBXT and Connective Tissue |