TET3 Antibody
Référence MBS151041-5x0,1mg
Conditionnement : 5x0.1mg
Marque : MyBiosource
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Western blot analysis of TET3 in SK-N-SH cell lysate with TET3 antibody at 1 μg/ml in (A) the absence and (B) the presence of blocking peptide.
Immunohistochemistry of TET3 in human brain tissue with TET3 antibody at 2.5 μg/ml.
Immunofluorescence of TET3 in human brain tissue with TET3 antibody at 20 μg/mL.
TET3 Antibody – Rabbit Polyclonal
For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS151041MBS151041 is an antibody targeting TET3. Also known as TET3 Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit. More details
Product Overview
Online Datasheet in PDFProduct Name
TET3, Polyclonal Antibody
Full Product Name
TET3 Antibody
Product Gene Name
anti-TET3 antibody
Product Synonym Names
TET3; hCG_40738; KIAA0401; Methylcytosine dioxygenase TET3; TET methylcytosine dioxygenase 3
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
Liquid; PBS containing 0.02% sodium azide.
Purity/Purification
TET3 Antibody is affinity chromatography purified via peptide column.
Concentration
1 mg/mL (lot specific)
Specificity
At least three isoforms of TET3 are known to exist. TET3 antibody is predicted to not cross react with other TET proteins.
Preparation and Storage
TET3 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Antibody/Peptide Pairs
TET3 peptide (MBS152112) is used for blocking the activity of TET3 antibody (MBS151041)
Applications Tested/Suitable for anti-TET3 antibody
ELISA, Immunofluorescence (IF), Immunohistochemistry-Paraffin (IHC-P), Western Blot (WB).
Other Notes
Small volumes of anti-TET3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Additional Details
NCBI/Uniprot data below describe general gene information for TET3. It may not necessarily be applicable to this product.
NCBI Official Synonym Full Names
tet methylcytosine dioxygenase 3
NCBI Official Symbol
TET3
NCBI Official Synonym Symbols
hCG_40738
UniProt Protein Name
Methylcytosine dioxygenase TET3
Protein Family
Methylcytosine dioxygenase
UniProt Gene Name
TET3
UniProt Synonym Gene Names
KIAA0401
UniProt Entry Name
TET3_HUMAN
NCBI Protein Information
methylcytosine dioxygenase TET3
NCBI Summary for TET3
Members of the ten-eleven translocation (TET) gene family, including TET3, play a role in the DNA methylation process (Langemeijer et al., 2009 [PubMed 19923888]).[supplied by OMIM, Nov 2010]
UniProt Comments for TET3
TET3: Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5- hydroxymethylcytosine (5hmC) and plays a key role in epigenetic chromatin reprogramming in the zygote following fertilization. Conversion into 5hmC initiates a process leading to cytosine demethylation through deamination into 5-hydroxymethyluracil (5hmU) and subsequent replacement by unmethylated cytosine by the base excision repair system. In zygotes, DNA demethylation occurs selectively in the paternal pronucleus before the first cell division, while the adjacent maternal pronucleus and certain paternally-imprinted loci are protected from this process. Participates in DNA demethylation in the paternal pronucleus by mediating conversion of 5mC into 5hmC. Does not mediate DNA demethylation of maternal pronucleus because of the presence of DPPA3/PGC7 on maternal chromatin that prevents TET3-binding to chromatin. Belongs to the TET family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Oxidoreductase; EC 1.14.11.n2
Chromosomal Location of Human Ortholog: 2p13.1
Cellular Component: male pronucleus; cytoplasm; female pronucleus
Molecular Function: protein binding; DNA binding; metal ion binding
Biological Process: protein amino acid O-linked glycosylation; gene expression; positive regulation of transcription from RNA polymerase II promoter; regulation of gene expression, epigenetic
Show more Protein type: Oxidoreductase; EC 1.14.11.n2
Chromosomal Location of Human Ortholog: 2p13.1
Cellular Component: male pronucleus; cytoplasm; female pronucleus
Molecular Function: protein binding; DNA binding; metal ion binding
Biological Process: protein amino acid O-linked glycosylation; gene expression; positive regulation of transcription from RNA polymerase II promoter; regulation of gene expression, epigenetic
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Product Note
Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.
Product PubMed Publications
Products associated with anti-TET3 antibody
| Reference Product | PubMed Publications |
|---|---|
| NANOG antibody | >5 publications with TET3 and NANOG |
Pathways associated with anti-TET3 antibody
| Products by Pathway | Pathway Diagram |
|---|---|
| Epigenetic Regulation Of Gene Expression Pathway antibodies | Epigenetic Regulation Of Gene Expression Pathway Diagram |
| Gene Expression Pathway antibodies | Gene Expression Pathway Diagram |
| TET1,2,3 And TDG Demethylate DNA Pathway antibodies | TET1,2,3 And TDG Demethylate DNA Pathway Diagram |
Diseases associated with anti-TET3 antibody
| Disease Name | Pubmed Publications |
|---|---|
| Kidney Diseases Antibodies | >2 publications with TET3 and Kidney Diseases |
| Adenocarcinoma Antibodies | >1 publications with TET3 and Adenocarcinoma |
| Cell Transformation, Neoplastic Antibodies | >1 publications with TET3 and Cell Transformation, Neoplastic |
| Adenoma Antibodies | >1 publications with TET3 and Adenoma |
| Necrosis Antibodies | >1 publications with TET3 and Necrosis |
| Intestinal Neoplasms Antibodies | >1 publications with TET3 and Intestinal Neoplasms |
| Death Antibodies | >1 publications with TET3 and Death |
Organs/Tissues associated with anti-TET3 antibody
| Organ/Tissue Name | Pubmed Publications |
|---|---|
| Brain Antibodies | >17 publications with TET3 and Brain |
| Embryonic Tissue Antibodies | >7 publications with TET3 and Embryonic Tissue |
| Bone Antibodies | >5 publications with TET3 and Bone |
| Liver Antibodies | >5 publications with TET3 and Liver |
| Blood Antibodies | >4 publications with TET3 and Blood |
| Prostate Antibodies | >2 publications with TET3 and Prostate |
| Lung Antibodies | >2 publications with TET3 and Lung |
| Pancreas Antibodies | >1 publications with TET3 and Pancreas |
| Eye Antibodies | >1 publications with TET3 and Eye |
| Testis Antibodies | >1 publications with TET3 and Testis |