Thymidine Phosphorylase (TYMP, ECGF1, Gliostatin, hPD-ECGF, MNGIE, PDECGF, PD-ECGF, Platelet-derived endothelial cell growth factor, TdRPase, TP)
Référence MBS606212-0,1mL
Conditionnement : 0.1mL
Marque : MyBiosource
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Western blot analysis of extracts from COS cells, untransfected or transfected with human ECGF1, and human THP-1 cells, using MBS606212.
Thymidine Phosphorylase (TYMP) Antibody – Rabbit Monoclonal
For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS606212Thymidine phosphorylase (TP) is a platelet-derived endothelial cell growth factor (PD-ECGF) that catalyzes the formation of thymine and 2-deoxy-D-ribose-1-phosphate from thymidine and orthophosphate. This intracellular enzyme is capable of both promoting… More details
Product Overview
Online Datasheet in PDFProduct Name
Thymidine Phosphorylase (Tymp), Monoclonal Antibody
Full Product Name
Thymidine Phosphorylase (TYMP, ECGF1, Gliostatin, hPD-ECGF, MNGIE, PDECGF, PD-ECGF, Platelet-derived endothelial cell growth factor, TdRPase, TP)
Product Gene Name
anti-Tymp antibody
Product Synonym Names
Anti -Thymidine Phosphorylase (TYMP, ECGF1, Gliostatin, hPD-ECGF, MNGIE, PDECGF, PD-ECGF, Platelet-derived endothelial cell growth factor, TdRPase, TP)
Clonality
Monoclonal
Isotype
IgG
Clone Number
D69B12
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in 10mM sodium HEPES pH 7.5, 150mM NaCl, 100ug/ml BSA, 0.02% sodium azide and 50% glycerol.
Purity/Purification
Purified
Specificity
Recongnizes endogenous levels of human total TP/ECGF1 protein.
Preparation and Storage
Store at -20°C. Aliquots are stable for 12 months after receipt.
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Chromosome Location
Chromosome: 15; NC_000081.5 (89202362..89207467, complement). Location: 15 F1; 15 51.6 cM
Immunogen
Synthetic peptide corresponding to residues surrounding Gln370 of human thymidine phosphorylase/ECGF1 protein (KLH-coupled).
Product Categories/Family for anti-Tymp antibody
Antibodies; Abs to Enzymes; Phosphorylase
Applications Tested/Suitable for anti-Tymp antibody
Western Blot (WB), Immunoprecipitation (IP)
Application Notes for anti-Tymp antibody
Suitable for use in Western Blot and Immunoprecipitation.
Dilution: Western Blot: 1:1000 Incubate membrane with diluted antibody in 5% w/v BSA, 1X TBS, 0.1% Tween-20 at 4 degree C with gentle shaking, overnight.
Immunoprecipitation: 1:100
Optimal dilutions should be determined by the researcher.
Other applications not tested.
Dilution: Western Blot: 1:1000 Incubate membrane with diluted antibody in 5% w/v BSA, 1X TBS, 0.1% Tween-20 at 4 degree C with gentle shaking, overnight.
Immunoprecipitation: 1:100
Optimal dilutions should be determined by the researcher.
Other applications not tested.
Other Notes
Small volumes of anti-Tymp antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Searchable Terms for Tymp purchase
MBS606212 is an antibody targeting Tymp. Also known as Thymidine Phosphorylase (TYMP, ECGF1, Gliostatin, hPD-ECGF, MNGIE, PDECGF, PD-ECGF, Platelet-derived endothelial cell growth factor, TdRPase, TP). Reactive in Human. Host: Rabbit.
Additional Details
NCBI/Uniprot data below describe general gene information for Tymp. It may not necessarily be applicable to this product.
NCBI Official Full Name
thymidine phosphorylase
NCBI Official Synonym Full Names
thymidine phosphorylase
NCBI Official Symbol
Tymp
NCBI Official Synonym Symbols
Ecgf1; PDECGF; Pdgfec; PD-ECGF; 2900072D10Rik
UniProt Protein Name
Thymidine phosphorylase
UniProt Synonym Protein Names
TdRPase
Protein Family
Thymidine phosphorylase
UniProt Gene Name
Tymp
UniProt Synonym Gene Names
Ecgf1
UniProt Entry Name
TYPH_MOUSE
NCBI Protein Information
thymidine phosphorylase; TP; tdRPase; gliostatin; platelet derived growth factor, endothelial cell; endothelial cell growth factor 1 (platelet-derived)
UniProt Comments for Tymp
ECGF1: May have a role in maintaining the integrity of the blood vessels. Has growth promoting activity on endothelial cells, angiogenic activity in vivo and chemotactic activity on endothelial cells in vitro. Homodimer. Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.
Protein type: Phosphorylase; Motility/polarity/chemotaxis; Xenobiotic Metabolism - drug metabolism - other enzymes; Transferase; EC 2.4.2.4; DNA replication; Nucleotide Metabolism - pyrimidine; Cytokine
Molecular Function: transferase activity; transferase activity, transferring glycosyl groups; thymidine phosphorylase activity; phosphorylase activity; transferase activity, transferring pentosyl groups; pyrimidine-nucleoside phosphorylase activity
Biological Process: organ morphogenesis; pyrimidine base metabolic process; metabolic process; chemotaxis; pyrimidine nucleoside metabolic process
Show more Protein type: Phosphorylase; Motility/polarity/chemotaxis; Xenobiotic Metabolism - drug metabolism - other enzymes; Transferase; EC 2.4.2.4; DNA replication; Nucleotide Metabolism - pyrimidine; Cytokine
Molecular Function: transferase activity; transferase activity, transferring glycosyl groups; thymidine phosphorylase activity; phosphorylase activity; transferase activity, transferring pentosyl groups; pyrimidine-nucleoside phosphorylase activity
Biological Process: organ morphogenesis; pyrimidine base metabolic process; metabolic process; chemotaxis; pyrimidine nucleoside metabolic process
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Product Note
Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.
Product PubMed Publications
Pathways associated with anti-Tymp antibody
| Products by Pathway | Pathway Diagram |
|---|---|
| (deoxy)ribose Phosphate Degradation Pathway antibodies | (deoxy)ribose Phosphate Degradation Pathway Diagram |
| Bladder Cancer Pathway antibodies | Bladder Cancer Pathway Diagram |
| Bladder Cancer Pathway antibodies | Bladder Cancer Pathway Diagram |
| Drug Metabolism - Other Enzymes Pathway antibodies | Drug Metabolism - Other Enzymes Pathway Diagram |
| Drug Metabolism - Other Enzymes Pathway antibodies | Drug Metabolism - Other Enzymes Pathway Diagram |
| Metabolic Pathways antibodies | Metabolic Pathways Diagram |
| Metabolism Of Nucleotides Pathway antibodies | Metabolism Of Nucleotides Pathway Diagram |
| Pyrimidine Catabolism Pathway antibodies | Pyrimidine Catabolism Pathway Diagram |
| Pyrimidine Metabolism Pathway antibodies | Pyrimidine Metabolism Pathway Diagram |
| Pyrimidine Metabolism Pathway antibodies | Pyrimidine Metabolism Pathway Diagram |
Diseases associated with anti-Tymp antibody
| Disease Name | Pubmed Publications |
|---|---|
| Mitochondrial Diseases Antibodies | >18 publications with Tymp and Mitochondrial Diseases |
| Muscular Diseases Antibodies | >12 publications with Tymp and Muscular Diseases |
| Central Nervous System Diseases Antibodies | >12 publications with Tymp and Central Nervous System Diseases |
| Neoplasms Antibodies | >8 publications with Tymp and Neoplasms |
| Cachexia Antibodies | >8 publications with Tymp and Cachexia |
| Carcinoma Antibodies | >4 publications with Tymp and Carcinoma |
| Vomiting Antibodies | >4 publications with Tymp and Vomiting |
| Pain Antibodies | >3 publications with Tymp and Pain |
| Hearing Loss Antibodies | >3 publications with Tymp and Hearing Loss |
| Adenocarcinoma Antibodies | >3 publications with Tymp and Adenocarcinoma |
Organs/Tissues associated with anti-Tymp antibody
| Organ/Tissue Name | Pubmed Publications |
|---|---|
| Brain Antibodies | >5 publications with Tymp and Brain |
| Liver Antibodies | >4 publications with Tymp and Liver |
| Skin Antibodies | >2 publications with Tymp and Skin |
| Eye Antibodies | >2 publications with Tymp and Eye |
| Intestine Antibodies | >1 publications with Tymp and Intestine |
| Lung Antibodies | >1 publications with Tymp and Lung |
| Inner Ear Antibodies | >1 publications with Tymp and Inner Ear |
| Mammary Gland Antibodies | >1 publications with Tymp and Mammary Gland |
| Embryonic Tissue Antibodies | >1 publications with Tymp and Embryonic Tissue |