TIMP1 Antibody
Référence MBS8582797-0,1mL-PE
Conditionnement : 0.1mL(PE)
Marque : MyBiosource
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TIMP1 Antibody – Rabbit Polyclonal
For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS8582797MBS8582797 is an antibody targeting TIMP1. Also known as TIMP1 Antibody. Reactive in Human, Mouse, Rat, Monkey. Host: Rabbit. Rabbit polyclonal antibody to TIMP1 More details
Product Overview
Online Datasheet in PDFProduct Name
TIMP1, Polyclonal Antibody
Full Product Name
TIMP1 Antibody
Product Gene Name
anti-TIMP1 antibody
Product Synonym Names
CLGI; TIMP; Metalloproteinase inhibitor 1; Erythroid-potentiating activity; EPA; Fibroblast collagenase inhibitor; Collagenase inhibitor; Tissue inhibitor of metalloproteinases 1; TIMP-1
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat, Monkey
Form/Format
Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH7.3, 30% glycerol, and 0.01% sodium azide.
Purity/Purification
The antibody was purified by immunogen affinity chromatography.
Specificity
Recognizes endogenous levels of TIMP1 protein.
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.
Molecular Weight
23,171 Da
Chromosome Location
Chromosome: X; NC_000023.10 (47441690..47446190). Location: Xp11.3-p11.23
OMIM
305370
Immunogen
KLH-conjugated synthetic peptide encompassing a sequence within the center region of human TIMP1. The exact sequence is proprietary.
Product Categories/Family for anti-TIMP1 antibody
Primary Antibody
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-TIMP1 antibody
Western Blot (WB), Flow Cytometry (FC/FACS/FCM)
Application Notes for anti-TIMP1 antibody
WB: 1:500-1:1000
FC
FC
Other Notes
Small volumes of anti-TIMP1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Additional Details
NCBI/Uniprot data below describe general gene information for TIMP1. It may not necessarily be applicable to this product.
UniProt Primary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
metalloproteinase inhibitor 1
NCBI Official Synonym Full Names
TIMP metallopeptidase inhibitor 1
NCBI Official Symbol
TIMP1
NCBI Official Synonym Symbols
EPA; EPO; HCI; CLGI; TIMP
UniProt Protein Name
Metalloproteinase inhibitor 1
UniProt Synonym Protein Names
Erythroid-potentiating activity; EPA; Fibroblast collagenase inhibitor; Collagenase inhibitor; Tissue inhibitor of metalloproteinases 1
Protein Family
Metalloproteinase inhibitor
UniProt Gene Name
TIMP1
UniProt Synonym Gene Names
CLGI; TIMP; EPA; Collagenase inhibitor; TIMP-1
UniProt Entry Name
TIMP1_HUMAN
NCBI Protein Information
metalloproteinase inhibitor 1; TIMP-1; collagenase inhibitor; erythroid potentiating activity; erythroid-potentiating activity; fibroblast collagenase inhibitor; tissue inhibitor of metalloproteinases 1
NCBI Summary for TIMP1
This gene belongs to the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases (MMPs), a group of peptidases involved in degradation of the extracellular matrix. In addition to its inhibitory role against most of the known MMPs, the encoded protein is able to promote cell proliferation in a wide range of cell types, and may also have an anti-apoptotic function. Transcription of this gene is highly inducible in response to many cytokines and hormones. In addition, the expression from some but not all inactive X chromosomes suggests that this gene inactivation is polymorphic in human females. This gene is located within intron 6 of the synapsin I gene and is transcribed in the opposite direction. [provided by RefSeq, Jul 2008]
Show more UniProt Comments for TIMP1
TIMP1: Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Also mediates erythropoiesis in vitro; but, unlike IL-3, it is species-specific, stimulating the growth and differentiation of only human and murine erythroid progenitors. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-11, MMP-12, MMP-13 and MMP-16. Does not act on MMP-14. Belongs to the protease inhibitor I35 (TIMP) family.
Protein type: Secreted, signal peptide; Secreted; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: Xp11.3-p11.23
Cellular Component: proteinaceous extracellular matrix; extracellular space; extracellular region; basement membrane
Molecular Function: metalloendopeptidase inhibitor activity; protein binding; protease binding; growth factor activity; metal ion binding; cytokine activity
Biological Process: response to peptide hormone stimulus; platelet activation; negative regulation of metalloenzyme activity; extracellular matrix organization and biogenesis; response to hormone stimulus; negative regulation of membrane protein ectodomain proteolysis; extracellular matrix disassembly; platelet degranulation; response to cytokine stimulus; positive regulation of cell proliferation; blood coagulation; aging; negative regulation of apoptosis
Show more Protein type: Secreted, signal peptide; Secreted; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: Xp11.3-p11.23
Cellular Component: proteinaceous extracellular matrix; extracellular space; extracellular region; basement membrane
Molecular Function: metalloendopeptidase inhibitor activity; protein binding; protease binding; growth factor activity; metal ion binding; cytokine activity
Biological Process: response to peptide hormone stimulus; platelet activation; negative regulation of metalloenzyme activity; extracellular matrix organization and biogenesis; response to hormone stimulus; negative regulation of membrane protein ectodomain proteolysis; extracellular matrix disassembly; platelet degranulation; response to cytokine stimulus; positive regulation of cell proliferation; blood coagulation; aging; negative regulation of apoptosis
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Product Note
Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.
Product PubMed Publications
Products associated with anti-TIMP1 antibody
| Reference Product | PubMed Publications |
|---|---|
| MMP2 antibody | >193 publications with TIMP1 and MMP2 |
| MMP1 antibody | >100 publications with TIMP1 and MMP1 |
| MMP3 antibody | >58 publications with TIMP1 and MMP3 |
| CD63 antibody | >5 publications with TIMP1 and CD63 |
Pathways associated with anti-TIMP1 antibody
| Products by Pathway | Pathway Diagram |
|---|---|
| Activation Of Matrix Metalloproteinases Pathway antibodies | Activation Of Matrix Metalloproteinases Pathway Diagram |
| Degradation Of The Extracellular Matrix Pathway antibodies | Degradation Of The Extracellular Matrix Pathway Diagram |
| Extracellular Matrix Organization Pathway antibodies | Extracellular Matrix Organization Pathway Diagram |
| HIF-1 Signaling Pathway antibodies | HIF-1 Signaling Pathway Diagram |
| Hemostasis Pathway antibodies | Hemostasis Pathway Diagram |
| IL6-mediated Signaling Events Pathway antibodies | IL6-mediated Signaling Events Pathway Diagram |
| Matrix Metalloproteinases Pathway antibodies | Matrix Metalloproteinases Pathway Diagram |
| Platelet Activation, Signaling And Aggregation Pathway antibodies | Platelet Activation, Signaling And Aggregation Pathway Diagram |
| Platelet Degranulation Pathway antibodies | Platelet Degranulation Pathway Diagram |
| Response To Elevated Platelet Cytosolic Ca2+ Pathway antibodies | Response To Elevated Platelet Cytosolic Ca2+ Pathway Diagram |
Diseases associated with anti-TIMP1 antibody
| Disease Name | Pubmed Publications |
|---|---|
| Neoplasms Antibodies | >176 publications with TIMP1 and Neoplasms |
| Fibrosis Antibodies | >108 publications with TIMP1 and Fibrosis |
| Cardiovascular Diseases Antibodies | >91 publications with TIMP1 and Cardiovascular Diseases |
| Inflammation Antibodies | >90 publications with TIMP1 and Inflammation |
| Vascular Diseases Antibodies | >65 publications with TIMP1 and Vascular Diseases |
| Necrosis Antibodies | >57 publications with TIMP1 and Necrosis |
| Liver Diseases Antibodies | >54 publications with TIMP1 and Liver Diseases |
| Heart Diseases Antibodies | >46 publications with TIMP1 and Heart Diseases |
| Female Urogenital Diseases Antibodies | >40 publications with TIMP1 and Female Urogenital Diseases |
| Liver Cirrhosis Antibodies | >32 publications with TIMP1 and Liver Cirrhosis |
Organs/Tissues associated with anti-TIMP1 antibody
| Organ/Tissue Name | Pubmed Publications |
|---|---|
| Blood Antibodies | >158 publications with TIMP1 and Blood |
| Vascular Antibodies | >84 publications with TIMP1 and Vascular |
| Liver Antibodies | >81 publications with TIMP1 and Liver |
| Lung Antibodies | >70 publications with TIMP1 and Lung |
| Bone Antibodies | >64 publications with TIMP1 and Bone |
| Muscle Antibodies | >63 publications with TIMP1 and Muscle |
| Heart Antibodies | >53 publications with TIMP1 and Heart |
| Connective Tissue Antibodies | >44 publications with TIMP1 and Connective Tissue |
| Kidney Antibodies | >43 publications with TIMP1 and Kidney |
| Skin Antibodies | >42 publications with TIMP1 and Skin |