XPC siRNA (Mouse)
Référence MBS829848-15nmol
Conditionnement : 15nmol
Marque : MyBiosource
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XPC siRNA – DNA Repair Protein Complementing Xp-C Cells Homolog (Mouse)
For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS829848MBS829848 is an siRNA targeting XPC. Also known as XPC siRNA (Mouse). Reactive in Mouse. Host: Synthetic. siRNA to inhibit XPC expression using RNA interference More details
Product Overview
Online Datasheet in PDFProduct Name
XPC, siRNA
Full Product Name
XPC siRNA (Mouse)
Product Gene Name
XPC sirna
Product Synonym Names
DNA repair protein complementing XP-C cells homolog; Xeroderma pigmentosum group C-complementing protein homolog; p125
Host
Synthetic
Species Reactivity
Mouse
Form/Format
Lyophilized powder
Purity/Purification
> 97%
Specificity
XPC siRNA (Mouse) is a target-specific 19-23 nt siRNA oligo duplexes designed to knock down gene expression.
Preparation and Storage
Shipped at 4 degree C. Store at -20 degree C for one year.
Molecular Weight
104,522 Da
Negative Control
siRNA Negative Control (Catalog# MBS8241404) is a non-targeting 21 nt siRNA recommended as a negative control for experiments using targeted siRNA transfection.
Quality Control
Oligonucleotide synthesis is monitored base by base through trityl analysis to ensure appropriate coupling efficiency. The oligo is subsequently purified by affinity-solid phase extraction. The annealed RNA duplex is further analyzed by mass spectrometry to verify the exact composition of the duplex. Each lot is compared to the previous lot by mass spectrometry to ensure maximum lot-to-lot consistency.
Directions for Use
We recommends transfection with 100 nM siRNA 48 to 72 hours prior to cell lysis. Before resuspending, briefly centrifuge the tube to ensure the lyophilized siRNA is at the bottom of the tube. Resuspend the siRNA oligos to an appropriate concentration with DEPC water. For each vial, suitable for 250 transfections in 24 well plate (20 pmol for each well).
Components
We offer pre-designed sets of 3 different target-specific siRNA oligo duplexes of mouse XPC gene. Each vial contains 5 nmol of lyophilized siRNA. The duplexes can be transfected individually or pooled together to achieve knockdown of the target gene, which is most commonly assessed by qPCR or western blot. Our siRNA oligos are also chemically modified (2'-OMe) at no extra charge for increased stability and enhanced knockdown in vitro and in vivo.
Applications Tested/Suitable for XPC sirna
RNA Interference (RNAi)
Other Notes
Small volumes of XPC sirna vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Additional Details
NCBI/Uniprot data below describe general gene information for XPC. It may not necessarily be applicable to this product.
NCBI Official Full Name
DNA repair protein complementing XP-C cells homolog
NCBI Official Synonym Full Names
xeroderma pigmentosum, complementation group C
NCBI Official Symbol
Xpc
UniProt Protein Name
DNA repair protein complementing XP-C cells homolog
UniProt Synonym Protein Names
Xeroderma pigmentosum group C-complementing protein homolog; p125
Protein Family
DNA repair protein
UniProt Gene Name
Xpc
UniProt Entry Name
XPC_MOUSE
NCBI Protein Information
DNA repair protein complementing XP-C cells homolog
UniProt Comments for XPC
XPC: a probable nuclear protein involved in DNA excision repair. May play a part in DNA damage recognition and/or in altering chromatin structure to allow access by damage-processing enzymes. Defects in XPC are a cause of xeroderma pigmentosum complementation group C.
Protein type: DNA repair, damage
Cellular Component: cytoplasm; plasma membrane; nucleolus; nucleus
Molecular Function: DNA binding; damaged DNA binding; single-stranded DNA binding
Biological Process: nucleotide-excision repair, DNA damage recognition; nucleotide-excision repair; intra-S DNA damage checkpoint; DNA repair; response to DNA damage stimulus; response to UV-B
Show more Protein type: DNA repair, damage
Cellular Component: cytoplasm; plasma membrane; nucleolus; nucleus
Molecular Function: DNA binding; damaged DNA binding; single-stranded DNA binding
Biological Process: nucleotide-excision repair, DNA damage recognition; nucleotide-excision repair; intra-S DNA damage checkpoint; DNA repair; response to DNA damage stimulus; response to UV-B
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Product Note
Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.
Product PubMed Publications
Products associated with XPC sirna
| Reference Product | PubMed Publications |
|---|---|
| Xpa sirna | >266 publications with XPC and Xpa |
| Ercc1 sirna | >106 publications with XPC and Ercc1 |
| Ercc2 sirna | >95 publications with XPC and Ercc2 |
| Rad23b sirna | >71 publications with XPC and Rad23b |
| Ddb2 sirna | >70 publications with XPC and Ddb2 |
| Ercc5 sirna | >35 publications with XPC and Ercc5 |
| Ercc4 sirna | >30 publications with XPC and Ercc4 |
| Cetn2 sirna | >23 publications with XPC and Cetn2 |
| Ercc3 sirna | >14 publications with XPC and Ercc3 |
| Gtf2h1 sirna | >2 publications with XPC and Gtf2h1 |
Pathways associated with XPC sirna
| Products by Pathway | Pathway Diagram |
|---|---|
| DNA Damage Recognition In GG-NER Pathway antibodies | DNA Damage Recognition In GG-NER Pathway Diagram |
| DNA Repair Pathway antibodies | DNA Repair Pathway Diagram |
| Dual Incision Reaction In GG-NER Pathway antibodies | Dual Incision Reaction In GG-NER Pathway Diagram |
| Formation Of Incision Complex In GG-NER Pathway antibodies | Formation Of Incision Complex In GG-NER Pathway Diagram |
| Global Genomic NER (GG-NER) Pathway antibodies | Global Genomic NER (GG-NER) Pathway Diagram |
| Metabolism Of Proteins Pathway antibodies | Metabolism Of Proteins Pathway Diagram |
| Nucleotide Excision Repair Pathway antibodies | Nucleotide Excision Repair Pathway Diagram |
| Nucleotide Excision Repair Pathway antibodies | Nucleotide Excision Repair Pathway Diagram |
| Nucleotide Excision Repair Pathway antibodies | Nucleotide Excision Repair Pathway Diagram |
| Post-translational Protein Modification Pathway antibodies | Post-translational Protein Modification Pathway Diagram |
Diseases associated with XPC sirna
| Disease Name | Pubmed Publications |
|---|---|
| Precancerous Conditions Antibodies | >160 publications with XPC and Precancerous Conditions |
| Lung Neoplasms Antibodies | >57 publications with XPC and Lung Neoplasms |
| Carcinoma, Squamous Cell Antibodies | >40 publications with XPC and Carcinoma, Squamous Cell |
| Breast Neoplasms Antibodies | >38 publications with XPC and Breast Neoplasms |
| Nervous System Diseases Antibodies | >36 publications with XPC and Nervous System Diseases |
| Urinary Bladder Neoplasms Antibodies | >34 publications with XPC and Urinary Bladder Neoplasms |
| Neoplasms, Experimental Antibodies | >25 publications with XPC and Neoplasms, Experimental |
| Chromosome Aberrations Antibodies | >22 publications with XPC and Chromosome Aberrations |
| Cell Transformation, Neoplastic Antibodies | >15 publications with XPC and Cell Transformation, Neoplastic |
| Liver Neoplasms Antibodies | >14 publications with XPC and Liver Neoplasms |
Organs/Tissues associated with XPC sirna
| Organ/Tissue Name | Pubmed Publications |
|---|---|
| Skin Antibodies | >149 publications with XPC and Skin |
| Lung Antibodies | >79 publications with XPC and Lung |
| Blood Antibodies | >75 publications with XPC and Blood |
| Bladder Antibodies | >42 publications with XPC and Bladder |
| Liver Antibodies | >37 publications with XPC and Liver |
| Prostate Antibodies | >17 publications with XPC and Prostate |
| Bone Antibodies | >15 publications with XPC and Bone |
| Brain Antibodies | >14 publications with XPC and Brain |
| Testis Antibodies | >9 publications with XPC and Testis |
| Inner Ear Antibodies | >7 publications with XPC and Inner Ear |