Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Mitoxantrone dihydrochloride [70476-82-3]
Référence T0158-50mg
Conditionnement : 50mg
Marque : TargetMol
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Mitoxantrone dihydrochloride
Catalog No. T0158 CAS 70476-82-3
Synonyms: Mitoxantrone 2HCl, Mitoxantrone hydrochloride, NSC-301739, mitozantrone dihydrochloride
Mitoxantrone dihydrochloride (NSC-301739) is the hydrochloride salt of an anthracenedione antibiotic with antineoplastic activity. It is a type II topoisomerase inhibitor.
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Mitoxantrone dihydrochloride, CAS 70476-82-3
| Description | Mitoxantrone dihydrochloride (NSC-301739) is the hydrochloride salt of an anthracenedione antibiotic with antineoplastic activity. It is a type II topoisomerase inhibitor. |
| Targets&IC50 | PKC:8.5 μM |
| In vitro | In a murine air pouch model of inflammation, methotrexate demonstrated an inhibitory concentration 50 (IC50) of 0.08 mg/kg per week. |
| In vivo | Methotrexate inhibits the de novo synthesis of purines and pyrimidines, the formation of polyamines, and the transmethylation reactions of DNA, RNA, phospholipids, and proteins. It suppresses the enzyme thymidylate synthase, leading to a deficiency of thymidylate inside cells, which ultimately results in antiproliferative cytotoxicity. Methotrexate enters cells either through active transport or facilitated diffusion and, once inside, polyglutamation inhibits dihydrofolate reductase, preventing the conversion of dihydrofolate to tetrahydrofolate. |
| Cell Research | The human breast carcinoma cell lines MDA-MB-231 and MCF-7 are seeded in standard 96-well plates. One day after seeding, the culture medium is changed and replaced by medium containing different concentration of Mitoxantrone (10-5 to 5 μM) with or without DHA (30 μM) during 7 days. Viability of cells are measured as a whole by the tetrazolium salt assay[3]. |
| Synonyms | Mitoxantrone 2HCl, Mitoxantrone hydrochloride, NSC-301739, mitozantrone dihydrochloride |
| Molecular Weight | 517.4 |
| Formula | C22H30Cl2N4O6 |
| CAS No. | 70476-82-3 |
Storage
Solubility Information
DMSO: 38.8 mg/mL (75 mM)
H2O: 2.6 mg/mL (5 mM)
References and Literature
1. Seitz M. Curr Opin Rheumatol, 1999, 11(3), 226-232. 2. Hirata S, et al. Arthritis Rheum, 1989, 32(9), 1065-1073. 3. Segal R, et al. Semin Arthritis Rheum, 1990, 20(3), 190-200. 4. Genestier L, et al. J Clin Invest, 1998, 102(2), 322-328. 5. Cronstein BN, et al. J Clin Invest, 1993, 92(6):2675-2682.