SD-36 TFA
Référence T18680L-1mg
Conditionnement : 1mg
Marque : TargetMol
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SD-36 TFA
(Synonyms: SD-36 TFA(2429877-44-9 Free base), SD36 TFA, SD 36 TFA) Copy Product Info
SD-36 TFA is a selective and highly efficient STAT3 degrader with a Kd value of about 50 nM.SD-36 has anticancer and antitumor activity, and can break down mutant STAT3 proteins in cells and inhibit STAT3 transcription.SD-36 promotes growth inhibition and induces apoptosis through inhibition of Mcl-1 in gliomas.
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Purity:99.59%
Appearance:Solid
Color:White to Yellow
Product Information
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | SD-36 TFA is a selective and highly efficient STAT3 degrader with a Kd value of about 50 nM.SD-36 has anticancer and antitumor activity, and can break down mutant STAT3 proteins in cells and inhibit STAT3 transcription.SD-36 promotes growth inhibition and induces apoptosis through inhibition of Mcl-1 in gliomas. |
| Targets & IC50 | STAT3:50nM |
| In vitro | SD-36 inhibits the growth of a subset of acute myeloid leukemia and anaplastic large-cell lymphoma cell lines by inducing cell-cycle arrest and/or apoptosis；SD-36 (0.005-5 μM; 4 days) demonstrates potent activity (IC50＜2 μM) in MOLM-16, DEL, Karpas-299, KI-JK, SU-DHL-I, SUP-M2 cell lines[1]；SD-36 (1 μM; 5 hours) completely depletes both monomeric and dimeric STAT3 protein in MOLM-16 cells[1]. |
| Synonyms | SD-36 TFA(2429877-44-9 Free base), SD36 TFA, SD 36 TFA |
| Molecular Weight | 1272.17 |
| Formula | C61H63F5N9O14P |
| Smiles | O=C(NC(C1=CC=CC=C1)C2=CC=CC=C2)[C@H](CCC(N)=O)NC([C@H]3N4[C@](CCN(C[C@@H](C4=O)NC(C5=CC6=CC(C(F)(F)P(O)(O)=O)=CC=C6N5)=O)C(CCCCCC#CC7=C8C(C(N(C9C(NC(CC9)=O)=O)C8)=O)=CC=C7)=O)(00)CC3)=O.OC(C(F)(F)F)=O |
| Storage | Keep away from direct sunlight Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 150 mg/mL (117.91 mM)  | |||||||||||||||||||||||||||||||||||
| In Vivo Formulation | 10% DMSO+40% PEG300+5% Tween 80+45% Saline: 10 mg/mL (7.86 mM), Solution. 10% DMSO+90% Saline: < 10 mg/mL (7.86 mM), insoluble. Lower concentrations may be soluble, but exact solubility limit is unknown. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density. | ||||||||||||||||||||||||||||||||||||