1,2-dioleoyl-sn-glycero-3-phosphocholine

DOPC, or 1,2-dioleoyl-sn-glycero-3-phosphocholine, stands as a notable member of semi-synthetic lipids, distinguished by its derivation from oleic acid. Within the realm of membrane protein research, DOPC offers unique attributes that contribute to its widespread utilization and significance.

Oleic Acid Derivation: Synthesized from oleic acid, an unsaturated fatty acid, DOPC bears distinctive features imparted by its unsaturated acyl chains.
Unsaturated Fatty Acyl Chains: DOPC is characterized by two oleoyl groups, contributing to the lipid's fluidity and flexibility due to the presence of double bonds in its acyl chains.
Biophysical Flexibility: The unsaturation in DOPC's acyl chains imparts fluidity, allowing the lipid to remain in a liquid crystalline phase across a broad range of temperatures.

Applications in Membrane Protein Research:

Mimicking Biological Membranes: DOPC's fluid nature and unsaturation make it a suitable component for mimicking the fluidity of biological membranes. This is particularly valuable when studying membrane proteins in conditions that replicate physiological environments.
Biophysical Studies: Widely employed in biophysical studies, DOPC serves as a model lipid for investigating membrane properties, lipid-protein interactions, and the influence of lipid composition on membrane dynamics.
Liposomal Formulations: Beyond its role in membrane protein research, DOPC's flexibility has led to its use in liposomal formulations, serving as a versatile vehicle for drug delivery systems.

Frequently Asked Questions (FAQ)

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Are all dopc products available under the same terms and conditions?

No. Ordering, delivery, storage and documentation conditions may vary depending on the product type, the supplier and the applicable regulations. Certain product codes may require specific approval, specialised transport, a safety data sheet or additional information prior to ordering.