Expanded primary cells

EXPANDED PRIMARY CELLS

The use of primary cells in vitro is compromised by the limited quantity of cells that can be isolated from one donor, a lack of or very restricted proliferation capacity (e.g. hepatocytes) and/or the change from a differentiated state to an activated state (e.g. hepatic stellate cells). The use of immortalized cell lines on the other hand, is compromised by their transformed, cancerous phenotype.

HOW DOES IT WORK?

Using the upcyte® technology, primary cells are driven into proliferation using a viral gene transfer system, thus allowing controlled and reversible bypass of cell cycle control mechanisms without inducing immortalization, uncontrolled cell growth or changing the typical phenotype.

Therefore, upcyte® cells are available in sufficient quantities with a consistent quality that can be used for research, screening and drug development. We can expand up to 4000 vials per cell type and donor – data from different studies can now be compared while working with the same donor. upcyte® cells have a distinct advantage over commonly used cells with respect to the virtually unlimited availability of differentiated cells.

For each product a protocol for use and a certificate of analysis will be delivered. All cells have been tested for the absence of CMV, HIV, Hepatitis B and C and microbial contaminants (fungi, bacteria and mycoplasma). upcyte® cells are genetically modified cells (GMO, genetically modified organism) classified as risk group 1 and have to be handled in a genetic engineering facility carrying out genetic engineering work at Security Level 1 (e.g. S1 lab). upcyte® hepatocytes and upcyte® Endothelial Cells are officially classified as risk group 1 organisms by the German Federal Office of Consumer Protection and Food Safety (BVL) and the Central Committee on Biological Safety (ZKBS). For further information please use the following link and enter “upcyte” in the search box.

Nevertheless, the cells – like all products of human origin – should be handled as potentially infectious. No test procedure can completely guarantee the absence of infectious agents.

We offer a wide range of primary cells from different species. If you do not find the cells you need, we can nevertheless supply those to you. We offer a custom service that allows you to obtain the cell(s) you need, just give us your criteria. Contact our technical support for more information.

Frequently Asked Questions (FAQ)

How can I quickly find a expanded primary cells product?

To find a expanded primary cells product, use the search function by name, product code, supplier, brand or sub-category. You can also browse the product families listed on the page to identify an available product code, an alternative or an equivalent product.

Does Biovalley stock several product codes in the expanded primary cells category?

Yes, Biovalley distributes several product references in the expanded primary cells category, sourced from specialist suppliers. Depending on the product family, references may vary in terms of format, packaging, brand, supplier, technical specifications or availability.

Can I request a quote for expanded primary cells products?

Yes, you can request a quote for expanded primary cells products from the product page or by contacting Biovalley (info@biovalley.fr). To help us process your enquiry, please provide, where possible, the product name, catalogue reference, required quantity, the supplier or brand you are looking for, and the country of delivery.

How can I find out if a expanded primary cells product is available to order?

The availability of a expanded primary cells product depends on the product code, supplier, packaging and country of delivery. For up-to-date information, please check the product details page or contact Biovalley with the product code or name of the product you are looking for.

What should I do if I cannot find the expanded primary cells product I am looking for?

If the expanded primary cells product you are looking for does not appear in the catalogue, please contact Biovalley with the available information: product name, reference number, supplier, brand, format or packaging. The team will be able to search for the reference number within its network of suppliers or suggest an available alternative.

Are all expanded primary cells products available under the same terms and conditions?

No. Ordering, delivery, storage and documentation conditions may vary depending on the product type, the supplier and the applicable regulations. Certain product codes may require specific approval, specialised transport, a safety data sheet or additional information prior to ordering.