(Rac)-Modipafant [122956-68-7]
Cat# HY-108908-10mg
Size : 10mg
Brand : MedChemExpress
(Rac)-Modipafant (UK-74505) is an orally active, selective, long-acting irreversible platelet activating factor receptor (PAFR) antagonist. (Rac)-Modipafant prevents dengue infection.
For research use only. We do not sell to patients.
(Rac)-Modipafant Chemical Structure
CAS No. : 122956-68-7
This product is a controlled substance and not for sale in your territory.
Based on 1 publication(s) in Google Scholar
Other Forms of (Rac)-Modipafant:
- Modipafant Get quote
Description |
(Rac)-Modipafant (UK-74505) is an orally active, selective, long-acting irreversible platelet activating factor receptor (PAFR) antagonist. (Rac)-Modipafant prevents dengue infection[1][2][3]. |
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In Vivo |
(Rac)-Modipafant (UK-74505) (10 mg/kg; p.o.; twice a day until day 10) prevents Severe Dengue Infection[3]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Molecular Weight |
605.09 |
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Formula |
C34H29ClN6O3 |
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CAS No. |
122956-68-7 |
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Appearance |
Solid |
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Color |
Light yellow to yellow |
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SMILES |
O=C(C1=C(C2=CC=C(N3C(C)=NC4=C3C=CN=C4)C=C2)NC(C)=C(C(NC5=NC=CC=C5)=O)C1C6=CC=CC=C6Cl)OCC |
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Shipping | Room temperature in continental US; may vary elsewhere. |
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Storage |
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Solvent & Solubility |
In Vitro:
DMSO : 50 mg/mL (82.63 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) Preparing
Stock Solutions
View the Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol) Concentration (start) × Volume (start) = Concentration (final) × Volume (final) This equation is commonly abbreviated as: C1V1 = C2V2 In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
Dosage mg/kgAnimal weight Dosing volume Number of animals Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO
+
%
+
%
Tween-80
+
%
Saline
The co-solvents required include: DMSO,
. All of co-solvents are available by MedChemExpress (MCE).
, Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration:
mg/mL
Method for preparing stock solution:
mg
drug dissolved in
μL
DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take
μL DMSO stock solution, add
μL .
μL , mix evenly, next add
μL Tween 80, mix evenly, then add
μL Saline.
If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
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Purity & Documentation | |||||||||||||||||
References |
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Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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DMSO | 1 mM | 1.6526 mL | 8.2632 mL | 16.5265 mL | 41.3162 mL |
5 mM | 0.3305 mL | 1.6526 mL | 3.3053 mL | 8.2632 mL | |
10 mM | 0.1653 mL | 0.8263 mL | 1.6526 mL | 4.1316 mL | |
15 mM | 0.1102 mL | 0.5509 mL | 1.1018 mL | 2.7544 mL | |
20 mM | 0.0826 mL | 0.4132 mL | 0.8263 mL | 2.0658 mL | |
25 mM | 0.0661 mL | 0.3305 mL | 0.6611 mL | 1.6526 mL | |
30 mM | 0.0551 mL | 0.2754 mL | 0.5509 mL | 1.3772 mL | |
40 mM | 0.0413 mL | 0.2066 mL | 0.4132 mL | 1.0329 mL | |
50 mM | 0.0331 mL | 0.1653 mL | 0.3305 mL | 0.8263 mL | |
60 mM | 0.0275 mL | 0.1377 mL | 0.2754 mL | 0.6886 mL | |
80 mM | 0.0207 mL | 0.1033 mL | 0.2066 mL | 0.5165 mL |