ABHD2 Antibody - middle region
Cat# OAAB09376
Size : 400ul
Brand : Aviva Systems Biology
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ABHD2 Antibody - middle region (OAAB09376)
| Datasheets/Manuals | Printable datasheet for ABHD2 Antibody - middle region (OAAB09376) |
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| Predicted Species Reactivity | Bovine|Human|Mouse|Primate |
|---|---|
| Product Format | Liquid. PBS with 0.09% (W/V) sodium azide. |
| Clonality | Polyclonal |
| Isotype | Rabbit Ig |
| Host | Rabbit |
| Application | IHC-P,WB |
| :: | Function: Progesterone-dependent acylglycerol lipase that catalyzes hydrolysis of endocannabinoid arachidonoylglycerol (AG) from cell membrane. Acts as a progesterone receptor: progesterone-binding activates the acylglycerol lipase activity, mediating degradation of 1AG and 2AG to glycerol and arachidonic acid (AA). Plays a key role in sperm capacitation in response to progesterone by mediating degradation of 2AG, an inhibitor of the sperm calcium channel CatSper, leading to calcium influx via CatSper and sperm activation. May also play a role in smooth muscle cells migration (By similarity). Cellular Location: Cell projection, cilium, flagellum membrane; Single-pass type II membrane protein. Cell membrane; Single-pass type II membrane protein. Tissue Location: Present in sperm (at protein level). |
| Reconstitution and Storage | Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles. |
| Immunogen | This ABHD2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 263-292 amino acids from the Central region of human ABHD2. |
| Purification | This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Predicted Homology Based on Immunogen Sequence | Cow; Human; Mouse; Monkey |
| Concentration | Approximately 0.5mg/ml. Actual concentration varies with each lot. |
| Intended Use | For research use only, not for use in diagnostic or therapeutic procedures. |
| Application Info | WB: 1:1000 IHC-P: 1:10~50 |
| Gene Symbol | Abhd2|ABHD2 |
|---|---|
| Gene Full Name | abhydrolase domain containing 2|abhydrolase domain containing 2, acylglycerol lipase |
| Alias Symbols | 2-arachidonoylglycerol hydrolase, 2210009N18Rik, abhydrolase domain-containing protein 2, acetylesterase, alpha/beta hydrolase domain containing protein 2, alpha/beta hydrolase fold protein, HS1-2, LAB, Labh-2, LABH2, lung alpha/beta hydrolase 2, mmLABH2, monoacylglycerol lipase ABHD2, PHPS1-2, progesterone-sensitive lipase, protein PHPS1-2, QtsA-21018, testicular tissue protein Li 6, triacylglycerol lipase. |
| NCBI Gene Id | 101867085|11057|508717|54608 |
| Protein Name | Monoacylglycerol lipase ABHD2|monoacylglycerol lipase ABHD2 [Homo sapiens] |
| Description of Target | Progesterone-dependent acylglycerol lipase that catalyzes hydrolysis of endocannabinoid arachidonoylglycerol (AG) from cell membrane (PubMed:26989199). Acts as a progesterone receptor: progesterone-binding activates the acylglycerol lipase activity, mediating degradation of 1-arachidonoylglycerol (1AG) and 2-arachidonoylglycerol (2AG) to glycerol and arachidonic acid (AA) (PubMed:26989199). Plays a key role in sperm capacitation in response to progesterone by mediating degradation of 2AG, an inhibitor of the sperm calcium channel CatSper, leading to calcium influx via CatSper and sperm activation (PubMed:26989199). May also play a role in smooth muscle cells migration (By similarity).|Progesterone-dependent acylglycerol lipase that catalyzes hydrolysis of endocannabinoid arachidonoylglycerol (AG) from cell membrane. Acts as a progesterone receptor: progesterone-binding activates the acylglycerol lipase activity, mediating degradation of 1-arachidonoylglycerol (1AG) and 2-arachidonoylglycerol (2AG) to glycerol and arachidonic acid (AA) (By similarity). Involved in acrosomal reaction (PubMed:26989199). May also play a role in smooth muscle cells migration (PubMed:15721306).|Progesterone-dependent acylglycerol lipase that catalyzes hydrolysis of endocannabinoid arachidonoylglycerol (AG) from cell membrane. Acts as a progesterone receptor: progesterone-binding activates the acylglycerol lipase activity, mediating degradation of 1-arachidonoylglycerol (1AG) and 2-arachidonoylglycerol (2AG) to glycerol and arachidonic acid (AA) (By similarity). May also play a role in smooth muscle cells migration (By similarity). |
| Uniprot ID | P08910|Q4R2Y9|Q5EA42|Q9QXM0 |
| Protein Accession # | https://www.ncbi.nlm.nih.gov/protein/NP_008942.3,NP_690888.1 |
| Molecular Weight | 48315 |
