APC Linked Polyclonal Antibody to Myosin Binding Protein C, Cardiac (MYBPC3)
Cat# MBS2135673-5x5mL
Size : 5x5mL
Brand : MyBiosource
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Myosin Binding Protein C, Cardiac (MYBPC3) Antibody – Rabbit Polyclonal
For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS2135673MBS2135673 is an antibody targeting MYBPC3. Also known as APC Linked Polyclonal Antibody to Myosin Binding Protein C, Cardiac (MYBPC3). Reactive in Human, Rat, Pig. Host: Rabbit. More details
Product Overview
Online Datasheet in PDFProduct Name
Myosin Binding Protein C, Cardiac (MYBPC3), Polyclonal Antibody
Full Product Name
APC Linked Polyclonal Antibody to Myosin Binding Protein C, Cardiac (MYBPC3)
Product Gene Name
anti-MYBPC3 antibody
Product Synonym Names
MYBPC3/Myosin Binding Protein C, Cardiac; MYBPC3; FHC; CMH4; MYBPC; Cprotein, cardiac muscle isoform
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Rat, Pig
Form/Format
Liquid; PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
Purity/Purification
Affinity Chromatography
Concentration
>=0.1mg/mL (Please refer to the vial label for the specific concentration.) (lot specific)
Specificity
The antibody is a rabbit polyclonal antibody raised against MYBPC3. It has been selected for its ability to recognize MYBPC3 in immunohistochemical staining and western blotting.
Preparation and Storage
Store at 2 degree C to 8 degree C for frequent use, 20 degree C for 24 months
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
Matching Pairs
Unconjugated Antibody: MYBPC3 (MBS2139673)
APC Conjugated Antibody: MYBPC3 (MBS2135673)
APC Conjugated Antibody: MYBPC3 (MBS2135673)
Molecular Weight
140,762 Da
Chromosome Location
Chromosome: 11; NC_000011.9 (47352957..47374253, complement). Location: 11p11.2
OMIM
115197
Supply Chain Verification
Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.
Immunogen Type
Prokaryotic Recombinant proteins/RP
Sequence of Immunogen
Met1~Ala328
Conjugation
APC
Product Categories/Family for anti-MYBPC3 antibody
Cardiovascular biology; Primary, APC labeled
ISO Certification
Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.
Applications Tested/Suitable for anti-MYBPC3 antibody
Western Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunoprecipitation (IP)
Application Notes for anti-MYBPC3 antibody
WB: 0.52ug/mL
IHC: 520ug/mL
ICC: 520ug/mL
IHC: 520ug/mL
ICC: 520ug/mL
Other Notes
Small volumes of anti-MYBPC3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Additional Details
NCBI/Uniprot data below describe general gene information for MYBPC3. It may not necessarily be applicable to this product.
NCBI Official Full Name
myosin-binding protein C, cardiac-type
NCBI Official Synonym Full Names
myosin binding protein C, cardiac
NCBI Official Symbol
MYBPC3
NCBI Official Synonym Symbols
FHC; CMH4; MYBP-C
UniProt Protein Name
Myosin-binding protein C, cardiac-type
UniProt Synonym Protein Names
C-protein, cardiac muscle isoform
Protein Family
Myosin-binding protein
UniProt Gene Name
MYBPC3
UniProt Synonym Gene Names
Cardiac MyBP-C
UniProt Entry Name
MYPC3_HUMAN
NCBI Protein Information
myosin-binding protein C, cardiac-type; C-protein, cardiac muscle isoform
NCBI Summary for MYBPC3
MYBPC3 encodes the cardiac isoform of myosin-binding protein C. Myosin-binding protein C is a myosin-associated protein found in the cross-bridge-bearing zone (C region) of A bands in striated muscle. MYBPC3, the cardiac isoform, is expressed exclussively in heart muscle. Regulatory phosphorylation of the cardiac isoform in vivo by cAMP-dependent protein kinase (PKA) upon adrenergic stimulation may be linked to modulation of cardiac contraction. Mutations in MYBPC3 are one cause of familial hypertrophic cardiomyopathy. [provided by RefSeq, Jul 2008]
Show more UniProt Comments for MYBPC3
MYBPC3: Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role. Belongs to the immunoglobulin superfamily. MyBP family.
Protein type: Myosin-binding
Chromosomal Location of Human Ortholog: 11p11.2
Cellular Component: sarcomere; striated muscle thick filament; cytosol; A band
Molecular Function: identical protein binding; ATPase activator activity; myosin binding; structural constituent of muscle; metal ion binding; titin binding; actin binding; myosin heavy chain binding
Biological Process: heart morphogenesis; regulation of heart rate; positive regulation of ATPase activity; regulation of muscle filament sliding; regulation of striated muscle contraction; ventricular cardiac muscle morphogenesis; sarcomere organization; cell adhesion; myosin filament assembly; muscle filament sliding; cardiac muscle contraction
Disease: Left Ventricular Noncompaction 10; Cardiomyopathy, Familial Hypertrophic, 4
Show more Protein type: Myosin-binding
Chromosomal Location of Human Ortholog: 11p11.2
Cellular Component: sarcomere; striated muscle thick filament; cytosol; A band
Molecular Function: identical protein binding; ATPase activator activity; myosin binding; structural constituent of muscle; metal ion binding; titin binding; actin binding; myosin heavy chain binding
Biological Process: heart morphogenesis; regulation of heart rate; positive regulation of ATPase activity; regulation of muscle filament sliding; regulation of striated muscle contraction; ventricular cardiac muscle morphogenesis; sarcomere organization; cell adhesion; myosin filament assembly; muscle filament sliding; cardiac muscle contraction
Disease: Left Ventricular Noncompaction 10; Cardiomyopathy, Familial Hypertrophic, 4
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Product Note
Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.
Product PubMed Publications
Products associated with anti-MYBPC3 antibody
| Reference Product | PubMed Publications |
|---|---|
| TTN antibody | >5 publications with MYBPC3 and TTN |
| TNNI3K antibody | >2 publications with MYBPC3 and TNNI3K |
Pathways associated with anti-MYBPC3 antibody
| Products by Pathway | Pathway Diagram |
|---|---|
| Dilated Cardiomyopathy Pathway antibodies | Dilated Cardiomyopathy Pathway Diagram |
| Dilated Cardiomyopathy Pathway antibodies | Dilated Cardiomyopathy Pathway Diagram |
| Hypertrophic Cardiomyopathy (HCM) Pathway antibodies | Hypertrophic Cardiomyopathy (HCM) Pathway Diagram |
| Hypertrophic Cardiomyopathy (HCM) Pathway antibodies | Hypertrophic Cardiomyopathy (HCM) Pathway Diagram |
| Muscle Contraction Pathway antibodies | Muscle Contraction Pathway Diagram |
| Striated Muscle Contraction Pathway antibodies | Striated Muscle Contraction Pathway Diagram |
| Striated Muscle Contraction Pathway antibodies | Striated Muscle Contraction Pathway Diagram |
Diseases associated with anti-MYBPC3 antibody
| Disease Name | Pubmed Publications |
|---|---|
| Heart Diseases Antibodies | >168 publications with MYBPC3 and Heart Diseases |
| Cardiomyopathies Antibodies | >159 publications with MYBPC3 and Cardiomyopathies |
| Cardiomyopathy, Hypertrophic, Familial Antibodies | >78 publications with MYBPC3 and Cardiomyopathy, Hypertrophic, Familial |
| Hypertrophy Antibodies | >65 publications with MYBPC3 and Hypertrophy |
| Death, Sudden, Cardiac Antibodies | >42 publications with MYBPC3 and Death, Sudden, Cardiac |
| Cardiomyopathy, Familial Hypertrophic, 4 Antibodies | >25 publications with MYBPC3 and Cardiomyopathy, Familial Hypertrophic, 4 |
| Cardiomyopathy, Dilated Antibodies | >24 publications with MYBPC3 and Cardiomyopathy, Dilated |
| Congenital Abnormalities Antibodies | >7 publications with MYBPC3 and Congenital Abnormalities |
| Disease Models, Animal Antibodies | >7 publications with MYBPC3 and Disease Models, Animal |
| Heart Defects, Congenital Antibodies | >5 publications with MYBPC3 and Heart Defects, Congenital |
Organs/Tissues associated with anti-MYBPC3 antibody
| Organ/Tissue Name | Pubmed Publications |
|---|---|
| Heart Antibodies | >85 publications with MYBPC3 and Heart |
| Muscle Antibodies | >77 publications with MYBPC3 and Muscle |
| Lung Antibodies | >3 publications with MYBPC3 and Lung |