ARC, CT, Blocking Peptide
Cat# A3325P-50ug
Size : 50ug
Brand : US Biological
Contact local distributor :
Phone : +1 850 650 7790
A3325PARC, CT, Blocking Peptide
Specifications
GradePurified
Shipping TempBlue Ice
Storage Temp-20°C
Peptide corresponding to amino acids 191 to 208 of human origin (1).
Apoptosis is regulated by death domain (DD) and/or caspase recruitment domain (CARD) containing molecules and a caspase family of proteases. CARD domain containing cell death regulators include RAIDD, Apaf-1, caspase-9, and caspase-2. A novel CARD domain containing protein was recently identified and designated ARC for apoptosis repressor with CARD (1). ARC interacts with caspase-2 and –8 and inhibits enzymatic activity of caspase-8. ARC suppresses apoptosis induced by cell death adapters FADD and TRADD and by cell death receptors Fas, TNFR-1 and DR3. The messenger RNA of ARC is primarily expressed in skeletal muscle and cardiac tissue (1).
Applications
Source: Synthetic peptide|Purity: Purified|Concentration: ~0.2mg/ml|Form: Supplied as a liquid in PBS, pH 7.2, 0.1% BSA, 0.02% sodium azide.||Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Form
Supplied as a liquid in PBS, pH 7.2, 0.1% BSA, 0.02% sodium azide.
Purity
Purified
References
1. Koseki T, Inohara N, Chen S, Nunez G. ARC, an inhibitor of apoptosis expressed in skeletal muscle and heart that interacts selectively with caspases. Proc Natl Acad Sci U S A 1998;95:5156-60