Carbenoxolone disodium [7421-40-1]
Cat# T0992-25mg
Size : 25mg
Brand : TargetMol
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Carbenoxolone disodium
(Synonyms: Duogastrone, Bioral, Biogastrone) Copy Product Info
Carbenoxolone disodium (Duogastrone) salt is an agent derived from licorice root. It is used for the treatment of digestive tract ulcers, especially in the stomach. Antidiuretic side effects are frequent, but otherwise, the drug is low in toxicity.
Cas No. 7421-40-1
For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:99.69%
Appearance:Solid
Color:White
COA HNMR LCMS
Product Introduction
Carbenoxolone disodium AI Summary
Carbenoxolone disodium has demonstrated notable bioactivity across several assays. It has been classified as DILI negative in the Drug Induced Liver Injury Prediction System (DILIps) validation dataset. The compound inhibits sodium fluorescein uptake in both OATP1B3 and OATP1B1-transfected CHO cells at a concentration of 10 µM, with measurable pIC50 and Ki values, indicating its potency. Furthermore, Carbenoxolone disodium has shown effectiveness in blocking the entry of the Ebola virus, with AC50 values in the nanomolar and micromolar ranges. It also exhibits antiviral activity against SARS-CoV-2, inhibiting the virus-induced cytotoxicity in Caco-2 cells by 15.49% at 10 µM after 48 hours, and demonstrating a low inhibition index of 0.08333 for Vero E6 cells infected with SARS-CoV-2 at a 0.002 MOI after 72 hours. Additionally, the compound inhibits the SARS-CoV-2 3CL-Pro protease by 17.58% at 20 µM..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Carbenoxolone disodium (Duogastrone) salt is an agent derived from licorice root. It is used for the treatment of digestive tract ulcers, especially in the stomach. Antidiuretic side effects are frequent, but otherwise, the drug is low in toxicity. |
| Synonyms | Duogastrone, Bioral, Biogastrone |
| Molecular Weight | 614.72 |
| Formula | C34H48Na2O7 |
| Cas No. | 7421-40-1 |
| Smiles | [Na+].[Na+].CC1(C)C(CCC2(C)C1CCC1(C)C2C(=O)C=C2C3CC(C)(CCC3(C)CCC12C)C([O-])=O)OC(=O)CCC([O-])=O |
| Relative Density. | no data available |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||||||||||||||||||||||
| Solubility Information | H2O: 252.5 mg/mL (410.76 mM), Sonication is recommended.  DMSO: 13.75 mg/mL (22.37 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||||||||||||
| In Vivo Formulation | 10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (1.63 mM), Sonication is recommended. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | ||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||||||||||||
DMSO/H2O
H2O
Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density. | |||||||||||||||||||||||||||||||||||||||||