CHEK2 Antibody
Cat# OASG01556
Size : 100ul
Brand : Aviva Systems Biology
Contact local distributor :
Phone : +1 850 650 7790
CHEK2 Antibody (OASG01556)
| Datasheets/Manuals | Printable datasheet for anti-CHEK2 (OASG01556) antibody |
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| Predicted Species Reactivity | Human, Mouse, Rat, Monkey |
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| Product Format | Liquid. 1 mg/mL in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Clonality | Polyclonal |
| Isotype | IgG |
| Host | Rabbit |
| Application | WB, IHC |
| Reconstitution and Storage | Store at -20C. Avoid repeated freeze/thaw cycles. |
| Immunogen | Synthesized peptide derived from human Chk2 around the non-phosphorylation site of T383. Location: 330-410aa. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration | 1 mg/ml |
| Specificity | Chk2 Polyclonal Antibody detects endogenous levels of Chk2 protein. |
| Application Info | WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:5000; |
| Gene Symbol | CHEK2 |
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| Gene Full Name | checkpoint kinase 2 |
| Alias Symbols | CDS1, CHK2, LFS2, RAD53, hCds1, HuCds1, PP1425 |
| NCBI Gene Id | 11200; 50883; |
| Description of Target | In response to DNA damage and replication blocks, cell cycle progression is halted through the control of critical cell cycle regulators. The protein encoded by this gene is a cell cycle checkpoint regulator and putative tumor suppressor. It contains a forkhead-associated protein interaction domain essential for activation in response to DNA damage and is rapidly phosphorylated in response to replication blocks and DNA damage. When activated, the encoded protein is known to inhibit CDC25C phosphatase, preventing entry into mitosis, and has been shown to stabilize the tumor suppressor protein p53, leading to cell cycle arrest in G1. In addition, this protein interacts with and phosphorylates BRCA1, allowing BRCA1 to restore survival after DNA damage. Mutations in this gene have been linked with Li-Fraumeni syndrome, a highly penetrant familial cancer phenotype usually associated with inherited mutations in TP53. Also, mutations in this gene are thought to confer a predisposition to sarcomas, breast cancer, and brain tumors. This nuclear protein is a member of the CDS1 subfamily of serine/threonine protein kinases. Several transcript variants encoding different isoforms have been found for this gene. |
| Uniprot ID | O96017, Q9Z265 |
| Molecular Weight | 60 kDa |
