Epothilone B

Epothilone B is a new kind of cancer agents and microtubule function inhibitor with an IC50 of 3.5 nM. Epothilone B inhibits microtubule function. Microtubules are essential to cell division, and epothilones therefore stop cells from properly dividing. Epothilone B possesses the same biological effects as paclitaxel both in vitro and in cultured cells. epothilone B suppressed microtubule dynamics in a concentration-dependent manner coincident with mitotic block. At 0.2 nm epothilone B, dynamics were not significantly altered. At 2 nm epothilone B (IC33), the mean growth and shortening rates were decreased by 38 and 27%, respectively. Dynamicity was decreased by 47%. At the IC50, 80% of the cells had nearly complete stabilization of microtubule dynamics, and no anaphase or telophase figures were observed. [1][2][3]

Small volumes of Epothilone B, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS8506498 is an inhibitor targeting Epothilone B.