GIT2 Antibody
Cat# MBS8582252-0,1mL-FITC
Size : 0.1mL(FITC)
Brand : MyBiosource
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GIT2 Antibody – Rabbit Polyclonal
For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS8582252MBS8582252 is an antibody targeting GIT2. Also known as GIT2 Antibody. Reactive in Human, Chicken. Host: Rabbit. Rabbit polyclonal antibody to GIT2 More details
Product Overview
Online Datasheet in PDFProduct Name
GIT2, Polyclonal Antibody
Full Product Name
GIT2 Antibody
Product Gene Name
anti-GIT2 antibody
Product Synonym Names
KIAA0148; ARF GTPase-activating protein GIT2; ARF GAP GIT2; Cool-interacting tyrosine-phosphorylated protein 2; CAT-2; CAT2; G protein-coupled receptor kinase-interactor 2; GRK-interacting protein 2
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Chicken
Form/Format
Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH7.3, 30% glycerol, and 0.01% sodium azide.
Purity/Purification
The antibody was purified by immunogen affinity chromatography.
Specificity
Recognizes endogenous levels of GIT2 protein.
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.
Molecular Weight
84,543 Da
Chromosome Location
Chromosome: 12; NC_000012.11 (110367607..110434194, complement). Location: 12q24.1
OMIM
608564
Immunogen
KLH-conjugated synthetic peptide encompassing a sequence within the center region of human GIT2. The exact sequence is proprietary.
Product Categories/Family for anti-GIT2 antibody
Primary Antibody
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-GIT2 antibody
Western Blot (WB)
Application Notes for anti-GIT2 antibody
WB: 1:500-1:1000
Other Notes
Small volumes of anti-GIT2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Additional Details
NCBI/Uniprot data below describe general gene information for GIT2. It may not necessarily be applicable to this product.
NCBI Official Full Name
ARF GTPase-activating protein GIT2 isoform 6
NCBI Official Synonym Full Names
G protein-coupled receptor kinase interacting ArfGAP 2
NCBI Official Symbol
GIT2
NCBI Official Synonym Symbols
CAT2; CAT-2
UniProt Protein Name
ARF GTPase-activating protein GIT2
UniProt Synonym Protein Names
Cool-interacting tyrosine-phosphorylated protein 2; CAT-2; CAT2; G protein-coupled receptor kinase-interactor 2; GRK-interacting protein 2
Protein Family
ARF GTPase-activating protein
UniProt Gene Name
GIT2
UniProt Synonym Gene Names
KIAA0148; ARF GAP GIT2; CAT-2; CAT2
UniProt Entry Name
GIT2_HUMAN
NCBI Protein Information
ARF GTPase-activating protein GIT2; ARF GAP GIT2; GRK-interacting protein 2; G protein-coupled receptor kinase-interactor 2; cool-associated, tyrosine phosphorylated protein 2; cool-interacting tyrosine-phosphorylated protein 2
NCBI Summary for GIT2
This gene encodes a member of the GIT protein family, which interact with G protein-coupled receptor kinases and possess ADP-ribosylation factor (ARF) GTPase-activating protein (GAP) activity. GIT proteins traffic between cytoplasmic complexes, focal adhesions, and the cell periphery, and interact with Pak interacting exchange factor beta (PIX) to form large oligomeric complexes that transiently recruit other proteins. GIT proteins regulate cytoskeletal dynamics and participate in receptor internalization and membrane trafficking. This gene has been shown to repress lamellipodial extension and focal adhesion turnover, and is thought to regulate cell motility. This gene undergoes extensive alternative splicing to generate multiple isoforms, but the full-length nature of some of these variants has not been determined. The various isoforms have functional differences, with respect to ARF GAP activity and to G protein-coupled receptor kinase 2 binding. [provided by RefSeq, Sep 2008]
Show more UniProt Comments for GIT2
GIT2: possesses ADP-ribosylation factor (ARF) GTPase-activating protein (GAP) activity. Interacts with G protein-coupled receptor kinases. Associates with paxillin. Also interacts with PIX exchange factors. Regulates Golgi and actin cytoskeletal organization. Important in integrin-mediated cell adhesion. Ten alternatively spliced isoforms have been described and additional isoforms seem to exist. Contains 1 Arf-GAP domain and 3 ANK repeats.
Protein type: GAPs, ARF; Motility/polarity/chemotaxis; GAPs
Chromosomal Location of Human Ortholog: 12q24.1
Cellular Component: nucleoplasm; focal adhesion
Molecular Function: protein binding; zinc ion binding
Biological Process: behavioral response to pain; regulation of G-protein coupled receptor protein signaling pathway; positive regulation of GTPase activity
Show more Protein type: GAPs, ARF; Motility/polarity/chemotaxis; GAPs
Chromosomal Location of Human Ortholog: 12q24.1
Cellular Component: nucleoplasm; focal adhesion
Molecular Function: protein binding; zinc ion binding
Biological Process: behavioral response to pain; regulation of G-protein coupled receptor protein signaling pathway; positive regulation of GTPase activity
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Product Note
Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.
Product PubMed Publications
Products associated with anti-GIT2 antibody
| Reference Product | PubMed Publications |
|---|---|
| GIT1 antibody | >27 publications with GIT2 and GIT1 |
| PXN antibody | >5 publications with GIT2 and PXN |
| PAK1 antibody | >3 publications with GIT2 and PAK1 |
| PAK3 antibody | >2 publications with GIT2 and PAK3 |
| ADRBK1 antibody | >1 publications with GIT2 and ADRBK1 |
Pathways associated with anti-GIT2 antibody
| Products by Pathway | Pathway Diagram |
|---|---|
| Endocytosis Pathway antibodies | Endocytosis Pathway Diagram |
| Endocytosis Pathway antibodies | Endocytosis Pathway Diagram |
| Integrin-mediated Cell Adhesion Pathway antibodies | Integrin-mediated Cell Adhesion Pathway Diagram |
| Signaling Events Mediated By Focal Adhesion Kinase Pathway antibodies | Signaling Events Mediated By Focal Adhesion Kinase Pathway Diagram |
Diseases associated with anti-GIT2 antibody
| Disease Name | Pubmed Publications |
|---|---|
| Neoplasms Antibodies | >3 publications with GIT2 and Neoplasms |
| Pancreatic Neoplasms Antibodies | >1 publications with GIT2 and Pancreatic Neoplasms |
| Learning Disorders Antibodies | >1 publications with GIT2 and Learning Disorders |
| Inflammation Antibodies | >1 publications with GIT2 and Inflammation |
Organs/Tissues associated with anti-GIT2 antibody
| Organ/Tissue Name | Pubmed Publications |
|---|---|
| Blood Antibodies | >10 publications with GIT2 and Blood |
| Brain Antibodies | >7 publications with GIT2 and Brain |
| Vascular Antibodies | >6 publications with GIT2 and Vascular |
| Lung Antibodies | >5 publications with GIT2 and Lung |
| Muscle Antibodies | >2 publications with GIT2 and Muscle |
| Bone Antibodies | >2 publications with GIT2 and Bone |
| Connective Tissue Antibodies | >1 publications with GIT2 and Connective Tissue |
| Kidney Antibodies | >1 publications with GIT2 and Kidney |
| Ovary Antibodies | >1 publications with GIT2 and Ovary |
| Thymus Antibodies | >1 publications with GIT2 and Thymus |