Iopanoic acid [96-83-3]
Cat# T0960-200mg
Size : 200mg
Brand : TargetMol
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Iopanoic acid
(Synonyms: Iodopanoic acid, Acidum iopanoicum) Copy Product Info
Iopanoic acid is an iodine contrast agent and a 5'-Deiodinase inhibitor.
Cas No. 96-83-3
For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:97.06%
Appearance:Solid
Color:White
COA HNMR LCMS
Product Introduction
Iopanoic acid AI Summary
Iopanoic acid shows rapid distribution in various organs of female rats following intravenous administration, with detectable percentages in blood, heart, kidney, lung, and liver at both 5 and 30 minutes post-administration. Analysis through polyacrylamide gel electrophoresis indicates its presence in different plasma components such as low-density lipoprotein, high-density lipoprotein, and albumin at multiple time points. Bioactivity studies reveal that Iopanoic acid inhibits enzymes including Histone Lysine Methyltransferase G9a, ELG1-dependent DNA repair, and human tyrosyl-DNA phosphodiesterase 1 (TDP1), among others. It also exhibits antagonistic activity against cAMP-regulated guanine nucleotide exchange factor 2 (EPAC2) and blocks Ebola Virus entry under different screening conditions. Additionally, it inhibits sodium fluorescein uptake in OATP1B3- and OATP1B1-transfected CHO cells at a 10 µM concentration. Toxicologically, Iopanoic acid induces moderate to acute liver toxicity demonstrated by elevated clinical-chemistry markers (ALT and AST). However, there are no indications of chronic liver diseases or related conditions such as cirrhosis or cancer. In terms of antiviral activity, Iopanoic acid inhibits SARS-CoV-2 induced cytotoxicity in VERO-6 cells and Caco-2 cells, although with relatively high IC50 values exceeding 20,000 nM. It also exhibits minimal inhibition of the SARS-CoV-2 3CL-Pro protease. Furthermore, Iopanoic acid shows inhibitory potential on the human HDAC6 enzyme and antagonistic activity towards human TBXA2R and CHRM1 receptors, with agonist activity at human ADRA1A receptor. While it demonstrates binding to various receptors and enzymes, significant bioactivity is largely absent at target sites tested, as indicated by AC50 values above 30,000 nM for most targets except a few..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Iopanoic acid is an iodine contrast agent and a 5'-Deiodinase inhibitor. |
| Synonyms | Iodopanoic acid, Acidum iopanoicum |
| Molecular Weight | 570.93 |
| Formula | C11H12I3NO2 |
| Cas No. | 96-83-3 |
| Smiles | CCC(Cc1c(I)cc(I)c(N)c1I)C(O)=O |
| Relative Density. | 2.426g/cm3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 55 mg/mL (96.33 mM), Sonication is recommended.  | ||||||||||||||||||||||||||||||
| In Vivo Formulation | 10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (3.5 mM), Sonication is recommended. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density. | |||||||||||||||||||||||||||||||