LILRB1/CD85j/ILT2 Protein, Human, Recombinant (hFc)

1.Loaded LILRB1/CD85j/ILT2 Protein, Human, Recombinant (hFc) (Cat#TMPY-04781) on AHC Biosensor, can bind Monoclonal anti-human LILRB1 Antibody, mouse IgG with an affinity constant of 2.25 nM as determined in BLI assay (Sartorius Octet RED384) (Routinely tested).
2.Immobilized LILRB1/CD85j/ILT2 Protein, Human, Recombinant (hFc) (Cat#TMPY-04781) at 2 μg/mL (100 μL/well) can bind anti-LILRB1, Human IgG4, the EC50 is 4-12 ng/mL.

LILRB1/CD85j/ILT2 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 73.9 kDa and the accession number is D9IDM8.

Human

HEK293 Cells

≥ 95 % as determined by SDS-PAGE. ≥ 90 % as determined by SEC-HPLC.

LILRB1 (Leukocyte Immunoglobulin Like Receptor B1) is a Protein Coding gene. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). LILRB1 is encoded within the leukocyte receptor complex on 19q13.4, previously implicated to be a susceptibility region to systemic lupus erythematosus (SLE). LILRB1 binds to a wide range of Major Histocompatibility Complex Class I molecules (MHCIs) and transduces negative signals that can, for example, prevent the killing of MHCI-expressing cells. LILRB1 transcription is correlated with surface protein expression on NK cells. Diseases associated with LILRB1 include Alzheimer's Disease 12 and Severe Pre-Eclampsia.