Mouse CD5 Antibody : Biotin
Cat# OASB02290
Size : 0.5mg
Brand : Aviva Systems Biology
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Phone : +1 850 650 7790
Mouse CD5 Antibody : Biotin (OASB02290)
| Datasheets/Manuals | Printable datasheet for Mouse CD5 Antibody : Biotin (OASB02290) |
|---|
| Tested Species Reactivity | Mouse |
|---|---|
| Predicted Species Reactivity | Mouse |
| Product Format | Liquid. Phosphate buffered saline containing 0.1% sodium azide |
| Clonality | Monoclonal |
| Host | Rat |
| Conjugation | Biotin |
| Application | FC, IHC-F, IP |
| Additional Information | Description: CD5, also known as Lyt-1, is a monomeric type I transmembrane glycoprotein expressed on thymocytes, T lymphocytes, and a subset of B lymphocytes, but not on natural killer (NK) cells. It has been identified as the major ligand of the B-cell antigen CD72. The frequency of CD5+ B cells exhibits strain-dependent variation, and the phenotypic, anatomical, functional, developmental, and pathological characteristics of the CD5+ B cells suggest that they may represent a distinct lineage, known as B-1 cells. Binding of CD5 on the T cell surface can augment alloantigen- or mitogen-induced lymphocyte proliferation and induces increased cytosolic free calcium, IL-2 secretion, and IL-2R expression. It has been proposed that CD5 negatively regulates signal transduction mediated by the T-cell and B-cell receptors. |
| Reconstitution and Storage | Store at 2-8C |
| Immunogen | Spleen cells or thymocyte membranes |
| Concentration | 0.5 mg/mL |
| Specificity | CD5 |
| Gene Symbol | CD5 |
|---|---|
| Gene Full Name | CD5 antigen |
| Alias Symbols | Ly, Ly-, Ly-1, Ly-A, Lyt-, Ly-12, Lyt-1 |
| NCBI Gene Id | 12507 |
| Protein Name | T-cell surface glycoprotein CD5 |
| Uniprot ID | P13379 |
| Protein Accession # | NP_031676.3 |
| Nucleotide Accession # | NM_007650.3 |
