Mouse Leptin
Cat# MBS691546-0,2mg
Size : 0.2mg
Brand : MyBiosource
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Phone : +1 850 650 7790
Leptin (LEP) Mouse Active Protein
For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS691546Encoded by the ob (obese) gene, Leptin is an adipose-derived cytokine that suppresses appetite and increases thermogenesis. Leptin exerts its anorectic effect via signaling through a hypothalamic receptor termed OB-R. Leptin has been shown to reduce body… More details
Product Overview
Online Datasheet in PDFProduct Name
Leptin, Active Protein
Full Product Name
Mouse Leptin
Product Gene Name
Lep active protein
Product Synonym Names
Recombinant Murine Leptin
Sequence
MVPIQKVQDD TKTLIKTIVT RINDISHTQS VSAKQRVTGL DFIPGL HPIL SLSKMDQTLA VYQQVLTSLP SQNVLQIAND LENLRDLLHL L AFSKSCSLP QTSGLQKPES LDGVLEASLY STEVVALSRL QGSLQDI LQQ LDVSPEC
Host
E Coli
Species Reactivity
Mouse
Form/Format
Lyophilized
Purity/Purification
> 95% (SDS-PAGE; HPLC)
Molecular Weight
16.0 kDa
Chromosome Location
Chromosome: 6; NC_000072.6 (29060195..29073877). Location: 6 A3.3; 6 12.3 cM
Active Protein Note
Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.
Endotoxin Level
< 0.1 ng/ug of Leptin
Biological Activity
Murine Leptin has been shown to be biologically active in two different mouse obesity models, ob/ob and NZO. Both strains of mice were treated via intraperitoneal injection once daily at a dose of 5 ug Leptin/gm of body weight for 14 days. Significant effects on body weight, food consumption, and plasma glucose levels were observed to saline-treated controls.
Product Categories/Family for Lep active protein
Cytokines & Growth Factors
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of Lep active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Searchable Terms for Lep purchase
MBS691546 is an active protein targeting Lep. Also known as Mouse Leptin. Reactive in Mouse. Host: E Coli.
Additional Details
NCBI/Uniprot data below describe general gene information for Lep. It may not necessarily be applicable to this product.
NCBI Official Full Name
leptin
NCBI Official Synonym Full Names
leptin
NCBI Official Symbol
Lep
NCBI Official Synonym Symbols
ob; obese
UniProt Protein Name
Leptin
UniProt Synonym Protein Names
Obesity factor
Protein Family
Ethylene-responsive transcription factor
UniProt Gene Name
Lep
UniProt Synonym Gene Names
Ob
UniProt Entry Name
LEP_MOUSE
NCBI Protein Information
leptin; obesity factor
UniProt Comments for Lep
Function: May function as part of a signaling pathway that acts to regulate the size of the body fat depot. An increase in the level of LEP may act directly or indirectly on the CNS to inhibit food intake and/or regulate energy expenditure as part of a homeostatic mechanism to maintain constancy of the adipose mass.
Subcellular location: Secreted
Probable.
Involvement in disease: Defects in Lep are the cause of profound obesity and type II diabetes.
Sequence similarities: Belongs to the leptin family.
Show more Subcellular location: Secreted
Probable.
Involvement in disease: Defects in Lep are the cause of profound obesity and type II diabetes.
Sequence similarities: Belongs to the leptin family.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Product Note
Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.
Product PubMed Publications
Products associated with Lep active protein
| Reference Product | PubMed Publications |
|---|---|
| Lepr active protein | >156 publications with Lep and Lepr |
| Pparg active protein | >31 publications with Lep and Pparg |
| Tnf active protein | >22 publications with Lep and Tnf |
| Npy active protein | >18 publications with Lep and Npy |
| Stat3 active protein | >14 publications with Lep and Stat3 |
| Ghrl active protein | >11 publications with Lep and Ghrl |
| Retn active protein | >9 publications with Lep and Retn |
Pathways associated with Lep active protein
| Products by Pathway | Pathway Diagram |
|---|---|
| Adipocytokine Signaling Pathway antibodies | Adipocytokine Signaling Pathway Diagram |
| Adipocytokine Signaling Pathway antibodies | Adipocytokine Signaling Pathway Diagram |
| Adipogenesis Pathway antibodies | Adipogenesis Pathway Diagram |
| Cytokine-cytokine Receptor Interaction Pathway antibodies | Cytokine-cytokine Receptor Interaction Pathway Diagram |
| Cytokine-cytokine Receptor Interaction Pathway antibodies | Cytokine-cytokine Receptor Interaction Pathway Diagram |
| Developmental Biology Pathway antibodies | Developmental Biology Pathway Diagram |
| Incretin Synthesis, Secretion, And Inactivation Pathway antibodies | Incretin Synthesis, Secretion, And Inactivation Pathway Diagram |
| Jak-STAT Signaling Pathway antibodies | Jak-STAT Signaling Pathway Diagram |
| Jak-STAT Signaling Pathway antibodies | Jak-STAT Signaling Pathway Diagram |
| Leptin And Adiponectin Pathway antibodies | Leptin And Adiponectin Pathway Diagram |
Diseases associated with Lep active protein
| Disease Name | Pubmed Publications |
|---|---|
| Obesity Antibodies | >317 publications with Lep and Obesity |
| Pain Antibodies | >160 publications with Lep and Pain |
| Insulin Resistance Antibodies | >105 publications with Lep and Insulin Resistance |
| Hyperinsulinism Antibodies | >67 publications with Lep and Hyperinsulinism |
| Weight Gain Antibodies | >54 publications with Lep and Weight Gain |
| Weight Loss Antibodies | >50 publications with Lep and Weight Loss |
| Cardiovascular Diseases Antibodies | >49 publications with Lep and Cardiovascular Diseases |
| Fatty Liver Antibodies | >39 publications with Lep and Fatty Liver |
| Inflammation Antibodies | >36 publications with Lep and Inflammation |
| Liver Diseases Antibodies | >32 publications with Lep and Liver Diseases |
Organs/Tissues associated with Lep active protein
| Organ/Tissue Name | Pubmed Publications |
|---|---|
| Brain Antibodies | >198 publications with Lep and Brain |
| Adipose Tissue Antibodies | >156 publications with Lep and Adipose Tissue |
| Skin Antibodies | >102 publications with Lep and Skin |
| Bone Marrow Antibodies | >8 publications with Lep and Bone Marrow |
| Salivary Gland Antibodies | >5 publications with Lep and Salivary Gland |
| Bladder Antibodies | >5 publications with Lep and Bladder |
| Mammary Gland Antibodies | >3 publications with Lep and Mammary Gland |
| Thymus Antibodies | >2 publications with Lep and Thymus |