Recombinant DNMT3A protein
Cat# MBS388124-1mg
Size : 1mg
Brand : MyBiosource
Contact local distributor :
Phone : +1 850 650 7790
Recombinant DNMT3A protein gel. Recombinant DNMT3A protein was run on an 8% SDS-PAGE gel and stained with Coomassie blue.
Recombinant DNMT3A protein activity assay Recombinant DNMT3A protein activity was measured using DNMT Activity / Inhibition Assay, for 1 hour at 37 degree C
DNMT3A Recombinant Protein
For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS388124Background: (DNA (Cytosine-5-)-Methyltransferase 3) proteins such as DNMT3A (or DNMT 3A) are involved in DNA methylation, in which a methyl group is added to a cytosine residue on DNA, commonly at the C5 position of a CpG dinucleotide. DNMT3A has been shown… More details
Product Overview
Online Datasheet in PDFProduct Name
DNMT3A, Recombinant Protein
Full Product Name
Recombinant DNMT3A protein
Product Gene Name
DNMT3A recombinant protein
Product Synonym Names
TBRS; DNMT3A2; M.HsaIIIA
Host
Baculovirus
Form/Format
Recombinant DNMT3A protein is supplied in 25mM Tris pH8.0, 500mM NaCl, 5% Glycerol, 0.04% Triton X-100, 1mM DTT and 0.2mg/ml 3× peptide.
Purity/Purification
The recombinant protein is >95% pure by SDS-PAGE.
Preparation and Storage
Recombinant proteins in solution are temperature sensitive and must be stored at -80 degree C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
Ships with Dry Ice.
Ships with Dry Ice.
Molecular Weight
101858 Da
OMIM
602769
Source
Human
Tag
DYKDDDDK-Tag, His-Tag
Notes
Recombinant DNMT3A protein is suitable for use in enzyme kinetics, inhibitor screening, and selectivity profiling.
DNMT Activity Assay Conditions
DNMT Activity Assay Conditions: Assay was performed using DNMT Activity/Inhibition Assay, for 1 hour at 37 degree C.
Dry Ice Shipment
Extra charge fee may add to your shipping cost as dry ice is required to ship this product.
Product Categories/Family for DNMT3A recombinant protein
Recombinant Proteins; DNA Methyltransferase (DNMT)
Other Notes
Small volumes of DNMT3A recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Searchable Terms for DNMT3A purchase
MBS388124 is a recombinant protein targeting DNMT3A. Also known as Recombinant DNMT3A protein. Host: Baculovirus.
Additional Details
NCBI/Uniprot data below describe general gene information for DNMT3A. It may not necessarily be applicable to this product.
NCBI Official Full Name
DNA (cytosine-5)-methyltransferase 3A isoform a
NCBI Official Synonym Full Names
DNA (cytosine-5-)-methyltransferase 3 alpha
NCBI Official Symbol
DNMT3A
NCBI Official Synonym Symbols
TBRS; DNMT3A2; M.HsaIIIA
UniProt Protein Name
DNA (cytosine-5)-methyltransferase 3A
UniProt Synonym Protein Names
DNA methyltransferase HsaIIIA
Protein Family
DNA
UniProt Gene Name
DNMT3A
UniProt Synonym Gene Names
Dnmt3a; DNA MTase HsaIIIA; M.HsaIIIA
UniProt Entry Name
DNM3A_HUMAN
NCBI Protein Information
DNA (cytosine-5)-methyltransferase 3A
NCBI Summary for DNMT3A
CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase that is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes to the cytoplasm and nucleus and its expression is developmentally regulated. [provided by RefSeq, Mar 2016]
Show more Research Articles on DNMT3A
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Product Note
Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.
Product PubMed Publications
Products associated with DNMT3A recombinant protein
| Reference Product | PubMed Publications |
|---|---|
| DNMT1 recombinant protein | >687 publications with DNMT3A and DNMT1 |
| DNMT3B recombinant protein | >665 publications with DNMT3A and DNMT3B |
| DNMT3L recombinant protein | >138 publications with DNMT3A and DNMT3L |
| EZH2 recombinant protein | >88 publications with DNMT3A and EZH2 |
| MYC recombinant protein | >25 publications with DNMT3A and MYC |
| SUV39H1 recombinant protein | >16 publications with DNMT3A and SUV39H1 |
| EED recombinant protein | >7 publications with DNMT3A and EED |
| EHMT2 recombinant protein | >6 publications with DNMT3A and EHMT2 |
| ZBTB17 recombinant protein | >1 publications with DNMT3A and ZBTB17 |
Pathways associated with DNMT3A recombinant protein
| Products by Pathway | Pathway Diagram |
|---|---|
| Chromatin Modifying Enzymes Pathway antibodies | Chromatin Modifying Enzymes Pathway Diagram |
| Chromatin Organization Pathway antibodies | Chromatin Organization Pathway Diagram |
| Cysteine And Methionine Metabolism Pathway antibodies | Cysteine And Methionine Metabolism Pathway Diagram |
| Cysteine And Methionine Metabolism Pathway antibodies | Cysteine And Methionine Metabolism Pathway Diagram |
| DNA Methylation Pathway antibodies | DNA Methylation Pathway Diagram |
| Epigenetic Regulation Of Gene Expression Pathway antibodies | Epigenetic Regulation Of Gene Expression Pathway Diagram |
| Gene Expression Pathway antibodies | Gene Expression Pathway Diagram |
| Metabolic Pathways antibodies | Metabolic Pathways Diagram |
| Methionine Degradation Pathway antibodies | Methionine Degradation Pathway Diagram |
| Methionine Degradation Pathway antibodies | Methionine Degradation Pathway Diagram |
Diseases associated with DNMT3A recombinant protein
| Disease Name | Pubmed Publications |
|---|---|
| Disease Models, Animal Antibodies | >47 publications with DNMT3A and Disease Models, Animal |
| Adenocarcinoma Antibodies | >40 publications with DNMT3A and Adenocarcinoma |
| Breast Neoplasms Antibodies | >38 publications with DNMT3A and Breast Neoplasms |
| Liver Diseases Antibodies | >33 publications with DNMT3A and Liver Diseases |
| Carcinoma, Hepatocellular Antibodies | >30 publications with DNMT3A and Carcinoma, Hepatocellular |
| Liver Neoplasms Antibodies | >26 publications with DNMT3A and Liver Neoplasms |
| Lung Neoplasms Antibodies | >24 publications with DNMT3A and Lung Neoplasms |
| Neoplasms, Experimental Antibodies | >20 publications with DNMT3A and Neoplasms, Experimental |
| Inflammation Antibodies | >17 publications with DNMT3A and Inflammation |
| Ovarian Neoplasms Antibodies | >16 publications with DNMT3A and Ovarian Neoplasms |
Organs/Tissues associated with DNMT3A recombinant protein
| Organ/Tissue Name | Pubmed Publications |
|---|---|
| Blood Antibodies | >215 publications with DNMT3A and Blood |
| Brain Antibodies | >120 publications with DNMT3A and Brain |
| Liver Antibodies | >78 publications with DNMT3A and Liver |
| Lung Antibodies | >46 publications with DNMT3A and Lung |
| Embryonic Tissue Antibodies | >46 publications with DNMT3A and Embryonic Tissue |
| Muscle Antibodies | >32 publications with DNMT3A and Muscle |
| Testis Antibodies | >31 publications with DNMT3A and Testis |
| Nerve Antibodies | >28 publications with DNMT3A and Nerve |
| Skin Antibodies | >28 publications with DNMT3A and Skin |
| Prostate Antibodies | >27 publications with DNMT3A and Prostate |