RGMC Polyclonal Antibody
Cat# MBS8531619-0,1mL-AF647
Size : 0.1mL(AF647)
Brand : MyBiosource
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Phone : +1 850 650 7790
RGMC Antibody – Rabbit Polyclonal
For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS8531619MBS8531619 is an antibody targeting RGMC. Also known as RGMC Polyclonal Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit. More details
Product Overview
Online Datasheet in PDFProduct Name
RGMC, Polyclonal Antibody
Full Product Name
RGMC Polyclonal Antibody
Product Gene Name
anti-RGMC antibody
Product Synonym Names
Hemojuvelin; Hemochromatosis type 2 protein; RGM domain family member C; HFE2; HJV; RGMC
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Purity/Purification
Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Preparation and Storage
Store at-20 degree C for 1 year.
Applications Tested/Suitable for anti-RGMC antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-RGMC antibody
WB: 1:500-2000
ELISA: 1:5000-20000
ELISA: 1:5000-20000
Other Notes
Small volumes of anti-RGMC antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Additional Details
NCBI/Uniprot data below describe general gene information for RGMC. It may not necessarily be applicable to this product.
NCBI Official Full Name
hemojuvelin isoform c
NCBI Official Synonym Full Names
hemojuvelin BMP co-receptor
NCBI Official Symbol
HJV
NCBI Official Synonym Symbols
JH; HFE2; RGMC; HFE2A
UniProt Protein Name
Hemojuvelin
UniProt Synonym Protein Names
Hemochromatosis type 2 protein; RGM domain family member C
UniProt Gene Name
HFE2
UniProt Synonym Gene Names
HJV; RGMC
NCBI Protein Information
hemojuvelin
NCBI Summary for RGMC
The product of this gene is involved in iron metabolism. It may be a component of the signaling pathway which activates hepcidin or it may act as a modulator of hepcidin expression. It could also represent the cellular receptor for hepcidin. Two uORFs in the 5' UTR negatively regulate the expression and activity of the encoded protein. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. Defects in this gene are the cause of hemochromatosis type 2A, also called juvenile hemochromatosis (JH). JH is an early-onset autosomal recessive disorder due to severe iron overload resulting in hypogonadotrophic hypogonadism, hepatic fibrosis or cirrhosis and cardiomyopathy, occurring typically before age of 30. [provided by RefSeq, Oct 2015]
Show more UniProt Comments for RGMC
Acts as a bone morphogenetic protein (BMP) coreceptor. Through enhancement of BMP signaling regulates hepcidin (HAMP) expression and regulates iron homeostasis.
Research Articles on RGMC
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Product Note
Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.
Product PubMed Publications
Products associated with anti-RGMC antibody
| Reference Product | PubMed Publications |
|---|---|
| DCC antibody | >3 publications with RGMC and DCC |
| NEO1 antibody | >2 publications with RGMC and NEO1 |
Pathways associated with anti-RGMC antibody
| Products by Pathway | Pathway Diagram |
|---|---|
| Axon Guidance Pathway antibodies | Axon Guidance Pathway Diagram |
| BMP Receptor Signaling Pathway antibodies | BMP Receptor Signaling Pathway Diagram |
| Developmental Biology Pathway antibodies | Developmental Biology Pathway Diagram |
| Hfe Effect On Hepcidin Production Pathway antibodies | Hfe Effect On Hepcidin Production Pathway Diagram |
| Netrin-1 Signaling Pathway antibodies | Netrin-1 Signaling Pathway Diagram |
Diseases associated with anti-RGMC antibody
| Disease Name | Pubmed Publications |
|---|---|
| Hemochromatosis Antibodies | >139 publications with RGMC and Hemochromatosis |
| Anemia Antibodies | >38 publications with RGMC and Anemia |
| Liver Diseases Antibodies | >25 publications with RGMC and Liver Diseases |
| Inflammation Antibodies | >21 publications with RGMC and Inflammation |
| Disease Models, Animal Antibodies | >13 publications with RGMC and Disease Models, Animal |
| Liver Cirrhosis Antibodies | >11 publications with RGMC and Liver Cirrhosis |
| Heart Diseases Antibodies | >9 publications with RGMC and Heart Diseases |
| Fibrosis Antibodies | >7 publications with RGMC and Fibrosis |
| Carcinoma, Hepatocellular Antibodies | >6 publications with RGMC and Carcinoma, Hepatocellular |
| Fatty Liver Antibodies | >5 publications with RGMC and Fatty Liver |
Organs/Tissues associated with anti-RGMC antibody
| Organ/Tissue Name | Pubmed Publications |
|---|---|
| Liver Antibodies | >109 publications with RGMC and Liver |
| Blood Antibodies | >83 publications with RGMC and Blood |
| Muscle Antibodies | >27 publications with RGMC and Muscle |
| Heart Antibodies | >26 publications with RGMC and Heart |
| Testis Antibodies | >2 publications with RGMC and Testis |
| Nerve Antibodies | >1 publications with RGMC and Nerve |
| Embryonic Tissue Antibodies | >1 publications with RGMC and Embryonic Tissue |