Size : 10mg
Phone : +1 850 650 7790
Synonyms: GG167
| Description | Zanamivir (GG167) is a guanido-neuraminic acid that is used to inhibit NEURAMINIDASE. |
| Targets & IC50 | Influenza A:0.95 nM, Influenza B:2.7 nM |
| In vitro | Zanamivir reduces pulmonary viral titers and decreases morbidity and mortality rates in a lethal murine model infected with the virus. |
| In vivo | Zanamivir effectively reduces viral replication in vitro by inhibiting the influenza neuraminidase and preventing the cleavage of sialic acid residues. This interference blocks the spread of progeny viruses in mucosal secretions and lowers viral infectivity. Furthermore, Zanamivir diminishes the area of plaques formed by neuraminidase-deficient mutants, indicating that its action in disrupting cell-cell fusion is independent of its neuraminidase inhibition activity. The compound also prevents the adhesion and fusion of persistently infected cells with uninfected erythrocytes. Assessment through lipid mixing and content mixing reveals that Zanamivir does not affect erythrocyte adhesion but does inhibit HA2b-red blood cell fusion. Additionally, Zanamivir leads to decreased sensitivity in influenza A/H1N1 variants His274Asn, His274 gly, His274Ser, and His274 gln. |
| Synonyms | GG167 |
| Molecular Weight | 332.31 |
| Formula | C12H20N4O7 |
| Cas No. | 139110-80-8 |
| Smiles | N(C(C)=O)[C@H]1[C@]([C@@H]([C@@H](CO)O)O)(OC(C(O)=O)=C[C@@H]1NC(=N)N)13 |
| Relative Density. | 1.75 g/cm33 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||
| Solubility Information | H2O: 10 mg/mL (30.09 mM), Sonication and heating are recommended.  DMSO: < 1 mg/mL (insoluble) | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
H2O
Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density. | ||||||||||||||||||||||||||
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 µL Tween 80 and mix well until fully clarified.
3) Add 450 µL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
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