Zebrafish NF-kB p65 Polyclonal Antibody

The Rel/NF-kappaB Signal Transduction Pathway Rel or NF-kappaB (NF-kB) proteins comprise a family of structurally-related eukaryotic transcription factors that are involved in the control of a large number of normal cellular and organismal processes, such as immune and inflammatory responses, developmental processes, cellular growth, and apoptosis. In most cells, NF-kB is present as a latent, inactive, IκB-bound complex in the cytoplasm. When the pathway is activated, IκB proteins are phosphorylated and degraded, allowing NF-kB to translocate to the nucleus and regulate target gene expression. The p65 subunit (also known as RelA) is a major component of the most common NF-kB dimer (p65/p50) and plays a critical role in inflammatory and immune responses in zebrafish as well as in mammals.