Table 1: List of LymphoSign test markers
LymphoSign: A Molecular Approach to NHL Classification
Non-Hodgkin lymphomas (NHLs) represent a diverse group of lymphoid malignancies characterized by considerable morphological, immunophenotypic, and molecular heterogeneity. Their classification encompasses numerous distinct subtypes and, particularly in diagnostically challenging cases, requires the integration of histopathological examination, immunohistochemistry, and molecular analyses to ensure accurate diagnosis.
LymphoSign is a CE-IVD molecular assay developed to support the classification of B- and T-cell non-Hodgkin lymphomas.
Learn more about LymphoSign CE-IVD and explore a range of solutions designed to support lymphoma classification and diagnosis.
Key Features
Molecular approach for complex NHL classification
LymphoSign analyzes the expression of over 130 relevant genes and genetic markers (Table 1). The resulting FASTQ files are processed by the RT-MIS platform, which compares each expression profile with a database of more than 3,000 clinical cases.
Designed for diagnostic laboratory workflows
The LymphoSign workflow uses standard laboratory techniques and requires approximately half a day of hands-on work. Compatible with FFPE samples and low RNA input, the assay can be performed on Illumina MiSeq or NextSeq 500/550 platforms. The kit includes RT-MLPA probes, barcodes, sequencing primers and access to the RT-MIS bioinformatics platform.
Comprehensive RT-MIS report
The RT-MIS platform generates an interpretation report that may include B/T-cell origin, cell-of-origin prediction, classification, grade-related information, additional molecular features, expression comparisons and access to raw data.
Key benefits for pathologists and molecular biologists
Supports the classification of complex B- and T-cell NHL cases.
Analyzes more than 130 genes and genetic markers simultaneously.
AI-assisted classification trained on over 3,000 cases.
Compatible with FFPE tissue biopsies and low RNA input.
Requires approximately 100,000 reads per sample.
Includes RT-MIS bioinformatics analysis.
Provides access to raw data and CSV files.
Available in 8, 16, 24 and 48 reaction formats.
Explore LymphoSign for the classification of major B- and T-cell NHL subtypes, including DLBCL, follicular, mantle cell, marginal zone and small lymphocytic lymphomas, as well as AITL, ALCL, ATLL and NK/T-cell lymphomas.
Interested in integrating LymphoSign CE-IVD into your lymphoma diagnostic workflow?
Request product information, kit references, workflow details and technical support to help assess its implementation in your laboratory.
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These products are medical devices. Please follow the instructions of the manufacturer. |
