(-)-Epicatechin gallate [1257-08-5]
Cat# HY-N0002-5mg
Size : 5mg
Brand : MedChemExpress
(-)-Epicatechin gallate (Epicatechin gallate) inhibits cyclooxygenase-1 (COX-1) with an IC50 of 7.5 μM.
For research use only. We do not sell to patients.
(-)-Epicatechin gallate Chemical Structure
CAS No. : 1257-08-5
Size | Price | Stock | Quantity |
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Free Sample (0.1 - 0.5 mg) | Apply Now | ||
Solid + Solvent | |||
10 mM * 1 mL
in DMSO
ready for reconstitution
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USD 61 | In-stock | |
Solution | |||
10 mM * 1 mL in DMSO | USD 61 | In-stock | |
Solid | |||
5 mg | USD 55 | In-stock | |
10 mg | USD 77 | In-stock | |
25 mg | USD 132 | In-stock | |
50 mg | USD 220 | In-stock | |
100 mg | USD 330 | In-stock | |
200 mg | Get quote | ||
500 mg | Get quote |
* Please select Quantity before adding items.
This product is a controlled substance and not for sale in your territory.
Based on 4 publication(s) in Google Scholar
Other Forms of (-)-Epicatechin gallate:
- (-)-Epicatechin In-stock
- (-)-Epicatechin gallate (Standard) Get quote
4 Publications Citing Use of MCE (-)-Epicatechin gallate
•Related Screening Libraries:
•Related Small Molecules:
•Related Proteins:
View All COX Isoform Specific Products:
Biological Activity
Protocol
Purity & Documentation
References
Customer Review
Description |
(-)-Epicatechin gallate (Epicatechin gallate) inhibits cyclooxygenase-1 (COX-1) with an IC50 of 7.5 μM. |
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IC50 & Target |
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In Vitro |
(-)-Epicatechin gallate (Epicatechin gallate) exhibits >95% inhibitory activity at 70 μg/mL against cyclooxygenase-1 (COX-1) with an IC50 of 7.5 μM[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. |
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In Vivo |
(-)-Epicatechin gallate (Epicatechin gallate), a component of Rhei Rhizoma, is one of the active components of Onpi-to, a herbal medicine composed of five crude drugs (Rhei Rhizome, Glycyrrhizae Radix, Ginseng Radix, Zingiberis Rhizoma and Aconiti Tuber). Following intravenous injection of (-)-Epicatechin gallate (1.0 mg/kg) in rats, the plasma concentration vs. time curve is fitted in a three compartment model. Pharmacokinetic parameters for plasma Epicatechin gallate (ECG) are measured. ECG has a t1/2α of 0.038 h, a t1/2βof 0.291 h and a t1/2γ of 4.033 h . The CLtot of ECG is 4.19 L/h • kg. The Vdss is 12.39 L/kg[2]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. |
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Clinical Trial |
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Molecular Weight |
442.37 |
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Formula |
C22H18O10 |
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CAS No. | |||||||||||||
Appearance |
Solid |
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Color |
White to off-white |
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SMILES |
O=C(O[C@H]1[C@@H](C2=CC=C(O)C(O)=C2)OC3=CC(O)=CC(O)=C3C1)C4=CC(O)=C(O)C(O)=C4 |
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Structure Classification | |||||||||||||
Initial Source | |||||||||||||
Shipping | Room temperature in continental US; may vary elsewhere. |
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Storage |
4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light) |
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Solvent & Solubility |
In Vitro:
DMSO : ≥ 30 mg/mL (67.82 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) *"≥" means soluble, but saturation unknown. Preparing
Stock Solutions
View the Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol) Concentration (start) × Volume (start) = Concentration (final) × Volume (final) This equation is commonly abbreviated as: C1V1 = C2V2 In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
Dosage mg/kgAnimal weight Dosing volume Number of animals Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO
+
%
+
%
Tween-80
+
%
Saline
Calculation results:
Working solution concentration:
mg/mL
Method for preparing stock solution:
mg
drug dissolved in
μL
DMSO (Stock solution concentration: mg/mL).
*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take
μL DMSO stock solution, add
μL .
μL , mix evenly, next add
μL Tween 80, mix evenly, then add
μL Saline.
If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
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Purity & Documentation |
Purity: 98.57% |
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References |
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Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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DMSO | 1 mM | 2.2606 mL | 11.3028 mL | 22.6055 mL | 56.5138 mL |
5 mM | 0.4521 mL | 2.2606 mL | 4.5211 mL | 11.3028 mL | |
10 mM | 0.2261 mL | 1.1303 mL | 2.2606 mL | 5.6514 mL | |
15 mM | 0.1507 mL | 0.7535 mL | 1.5070 mL | 3.7676 mL | |
20 mM | 0.1130 mL | 0.5651 mL | 1.1303 mL | 2.8257 mL | |
25 mM | 0.0904 mL | 0.4521 mL | 0.9042 mL | 2.2606 mL | |
30 mM | 0.0754 mL | 0.3768 mL | 0.7535 mL | 1.8838 mL | |
40 mM | 0.0565 mL | 0.2826 mL | 0.5651 mL | 1.4128 mL | |
50 mM | 0.0452 mL | 0.2261 mL | 0.4521 mL | 1.1303 mL | |
60 mM | 0.0377 mL | 0.1884 mL | 0.3768 mL | 0.9419 mL |
(-)-Epicatechin gallate Related Classifications
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Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.
Bulk Inquiry
Inquiry Information
- Product Name:
- (-)-Epicatechin gallate
- Cat. No.:
- HY-N0002
- Quantity:
- MCE Japan Authorized Agent: