18-Oxocortisol [2410-60-8]
Cat# T39991-2mg
Size : 2mg
Brand : TargetMol
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18-Oxocortisol
Copy Product Info18-Oxocortisol is a cortisol derivative generated by aldosterone synthase (CYP11B2). It acts as a naturally occurring mineralocorticoid agonist and serves as a biomarker in adrenal vein sampling.
Cas No. 2410-60-8
For research use only—not for human use. No sales to individuals. Use as intended only.
Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | 18-Oxocortisol is a cortisol derivative generated by aldosterone synthase (CYP11B2). It acts as a naturally occurring mineralocorticoid agonist and serves as a biomarker in adrenal vein sampling. |
| In vivo | Administration of 18-oxocortisol in rats triggers mineralocorticoid-type hypertension, characterized by hypokalemia, as well as enlargement of cardiac and renal tissues and cardiovascular lesions. Similarly, when administered to sheep, 18-oxocortisol leads to a swift elevation in blood pressure. Nonetheless, achieving an increase in blood pressure necessitates high doses[3]. |
| Molecular Weight | 376.449 |
| Formula | C21H28O6 |
| Cas No. | 2410-60-8 |
| Smiles | 22[C@@]12CC[C@](O)(C(=O)CO)[C@]1(C[C@H](O)[C@@]1(22)[C@@]2(22)CCC2=CC(=O)CC[C@]12C)C=O |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |