General Info
Host: | Mouse |
Applications: | WB/IF/IP/IHC |
Reactivity: | Mouse/Human/Monkey/Hamster/Rat |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: | Mouse monoclonal antibody anti-Chromobox protein homolog 3 is suitable for use in Western Blot, Immunofluorescence, Immunoprecipitation and Immunohistochemistry research applications. |
Clonality: | Monoclonal |
Clone ID: | 5G10-F7-A12 |
Conjugation: | Unconjugated |
Isotype: | IgG1 |
Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
Purification: | The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen. |
Concentration: | 1 mg/mL |
Dilution Range: | WB 1:1000ICC 1:200IF 1:50-200 |
Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Information
Gene Symbol: | CBX3 |
Gene ID: | 11335 |
Uniprot ID: | CBX3_HUMAN |
Specificity: | This antibody detects endogenous levels of HP1-gamma and does not cross-react with related proteins. |
Immunogen: | Purified recombinant human HP1-gamma protein fragments expressed in E.coli. |
Description
Function | Seems to be involved in transcriptional silencing in heterochromatin-like complexes. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. May contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR). Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. Contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation, mediates the recruitment of the methyltransferases SUV39H1 and/or SUV39H2 by the PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1. Mediates the recruitment of NIPBL to sites of DNA damage at double-strand breaks (DSBs). |
Protein Name | Chromobox Protein Homolog 3HechHeterochromatin Protein 1 Homolog GammaHp1 GammaModifier 2 Protein |
Database Links | Reactome: R-HSA-427389Reactome: R-HSA-73772Reactome: R-HSA-8953750 |
Cellular Localisation | NucleusAssociates With Euchromatin And Is Largely Excluded From Constitutive HeterochromatinMay Be Associated With Microtubules And Mitotic Poles During Mitosis (Potential) |
Alternative Antibody Names | Anti-Chromobox Protein Homolog 3 antibodyAnti-Hech antibodyAnti-Heterochromatin Protein 1 Homolog Gamma antibodyAnti-Hp1 Gamma antibodyAnti-Modifier 2 Protein antibodyAnti-CBX3 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance