Anti-LILRB2 Polyclonal Antibody
Cat# NB-64-158245-100uL
Size : 100uL
Brand : Neo Biotech
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Anti-LILRB2 Polyclonal Antibody
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Catalog No. TMAB-08306 Copy Product Info
Anti-LILRB2 Polyclonal Antibody is a Rabbit antibody targeting LILRB2. Anti-LILRB2 Polyclonal Antibody can be used in WB.
For research use only—not for human use. No sales to individuals. Use as intended only.
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| Description | Anti-LILRB2 Polyclonal Antibody is a Rabbit antibody targeting LILRB2. Anti-LILRB2 Polyclonal Antibody can be used in WB. |
| Ig Type | IgG |
| Reactivity | Mouse (predicted:Human) |
| Verified Activity | 1. Sample: Bone marrow (Mouse) Lysate at 40 μg Lymph node (Mouse) Lysate at 40 μg Primary: Anti-LILRB2 (TMAB-08306) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 65 kD Observed band size: 65 kD 2. Sample: Bone (Mouse) Lysate at 40 μg Primary: Anti-LILRB2 (TMAB-08306) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 65 kD Observed band size: 65 kD |
| Application | WB |
| Recommended Dose | WB: 1:500-2000 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Membrane. |
| Tissue Specificity | Expressed on monocytes and B-cells, and at lower levels on dendritic cells. Detected at low levels in natural killer (NK) cells. |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1mg/ml |
| Research Background | Leukocyte immunoglobulin-like receptors (LIRs) are members of the immunoglobulin superfamily of glycoproteins and are predominantly expressed by monocytes, B cells, dendritic cells, natural killer (NK) cells, peripheral blood leukocytes and tissues such as placenta, lung and liver. These receptors all contain a cytoplasmic immunoreceptor tyrosine-based inhibitory motif (ITIM), have an inhibitory function and are type I membrane proteins. When they bind to MHC (or other ligands) and ITIM is tyrosine phosphorylated, protein-tyrosine phosphatases are recruited and an inhibitory signal cascade triggered. ILT-4, also designated LIR-2, MIR-10 or CD85D antigen, competes with CD8A for binding to class I MHC antigens. |
| Immunogen | KLH conjugated synthetic peptide: human LILRB2 |
| Antigen Species | Human |
| Gene Name | LILRB2 |
| Gene ID | 10288 |
| Protein Name | Leukocyte immunoglobulin-like receptor subfamily B member 2 |
| Uniprot ID | Q8N423 |
| Function | Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Involved in the down-regulation of the immune response and the development of tolerance. Competes with CD8A for binding to class I MHC antigens. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions. |
| Molecular Weight | Theoretical: 65 kDa. Actual: 65 kDa. |
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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