Reagents and instruments for immunology, cell biology and molecular biology.
 
> Anti-Phospho-STAT3 (Tyr705) Polyclonal Antibody

Anti-Phospho-STAT3 (Tyr705) Polyclonal Antibody

Print Print
Please log in

Cat# NB-64-114081-50uL

Size : 50uL

Brand : Neo Biotech

Contact local distributor :


Phone : +1 850 650 7790

Remove All

Anti-Phospho-STAT3 (Tyr705) Polyclonal Antibody

(Synonyms: Stat3 (p-Y705), Stat3 (p-Tyr705), signal transducer and activator of transcription 3 (acute-phase response factor), p-Stat3 (Y705), p-Stat3 (Tyr705), Phospho-Stat3 (Y705), HIES, APRF, ADMIO) Copy Product Info

Synonyms: Stat3 (p-Y705), Stat3 (p-Tyr705), signal transducer and activator of transcription 3 (acute-phase response factor), p-Stat3 (Y705), p-Stat3 (Tyr705), Phospho-Stat3 (Y705), HIES, APRF, ADMIO

Catalog No. TMAB-01509 Copy Product Info
Anti-Phospho-STAT3 (Tyr705) Polyclonal Antibody is a Rabbit antibody targeting Phospho-STAT3 (Tyr705). Anti-Phospho-STAT3 (Tyr705) Polyclonal Antibody can be used in WB.
For research use only—not for human use. No sales to individuals. Use as intended only.

Product Introduction

Bioactivity
Description
Anti-Phospho-STAT3 (Tyr705) Polyclonal Antibody is a Rabbit antibody targeting Phospho-STAT3 (Tyr705). Anti-Phospho-STAT3 (Tyr705) Polyclonal Antibody can be used in WB.
SynonymsStat3 (p-Y705), Stat3 (p-Tyr705), signal transducer and activator of transcription 3 (acute-phase response factor), p-Stat3 (Y705), p-Stat3 (Tyr705), Phospho-Stat3 (Y705), HIES, APRF, ADMIO
Ig Type
IgG
Reactivity
Mouse,Rat (predicted:Human)
Verified Activity
25 μg total protein per Lane of various lysates probed with phospho-STAT3 (Tyr705) polyclonal antibody, unconjugated (TMAB-01509) at 1:1000 dilution and 4°C overnight incubation. Followed by conjugated secondary antibody incubation at RT for 60 min.
Anti-Phospho-STAT3 (Tyr705) Polyclonal Antibody
Application
WB
Recommended Dose
WB: 1:500-2000
Antibody Type
Polyclonal
Host SpeciesRabbit
Subcellular LocalizationCytoplasm. Nucleus. Note=Shuttles between the nucleus and the cytoplasm. Translocated into the nucleus upon tyrosine phosphorylation and dimerization, in response to signaling by activated FGFR1, FGFR2, FGFR3 or FGFR4. Constitutive nuclear presence is independent of tyrosine phosphorylation. Predominantly present in the cytoplasm without stimuli. Upon leukemia inhibitory factor (LIF) stimulation, accumulates in the nucleus. The complex composed of BART and ARL2 plays an important role in the nuclear translocation and retention of STAT3. Identified in a complex with LYN and PAG1.
Tissue SpecificityHeart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
ConstructionPolyclonal Antibody
PurificationProtein A purified
AppearanceLiquid
Formulation0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Concentration1 mg/mL
Research BackgroundThe protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Mutations in this gene are associated with infantile-onset multisystem autoimmune disease and hyper-immunoglobulin E syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Sep 2015]
Antigen Details
Immunogen
KLH conjugated Synthesised phosphopeptide: human STAT3 around the phosphorylation site of Tyr705
Antigen Species
Human
Gene Name
STAT3
Gene ID
6774
Protein Name
Signal transducer and activator of transcription 3
Uniprot ID
P40763
Biology Area
STAT family,Transcription factors/regulators,Transcription factors,Surface molecules,STATs,Other factors,SARS Coronavirus,STATs,Intracellular
Function
Transcription factor that binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA.
Chemical Properties
Molecular WeightTheoretical: 85 kDa. Actual: 83 kDa.
Stability & Storage
Stability & StorageStore at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

Calculator

  • Dilution Calculator
  • Reconstitution Calculator

Keywords

Stat3 (pY705)Stat3 (pTyr705)Stat3 (phospho-Y705)Stat3 (phospho-Tyr705)pStat3 (Y705)pStat3 (Tyr705)acute-phase response factor
Related Tags: Anti-Phospho-STAT3 (Tyr705) Polyclonal Antibody molecular weight