Biotin-Linked Polyclonal Antibody to Phosphoinositide-3-Kinase Class 3 (PIK3C3)

PIK3C3: Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate which plays a key role in initiation and maturation of autophagosomes. Involved in the transport of lysosomal enzyme precursors to lysosomes. Required for the abcission step in cytokinesis. Required for transport from early to late endosomes. Heterodimer. This subunit, part of a complex composed of regulatory and catalytic subunits, associates with regulatory subunit PIK3R4. Forms a complex with BECN1, PIK3R4 and either UVRAG and KIAA0226/Rubicon, or with ATG14. In this complex, presence of UVRAG and ATG14 are mutually exclusive. Part of a complex composed of PIK3R4 and PIK3CB. Interacts with RAB7A in the presence of PIK3R4. Ubiquitously expressed, with a highest expression in skeletal muscle. Belongs to the PI3/PI4-kinase family.

Protein type: Autophagy; Carbohydrate Metabolism - inositol phosphate; EC 2.7.1.137; Kinase, lipid; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 18q12.3

Cellular Component: autolysosome; axoneme; cytosol; late endosome; membrane; midbody; peroxisome; phagocytic vesicle membrane; phagophore assembly site

Molecular Function: 1-phosphatidylinositol-3-kinase activity; ATP binding; kinase activity; protein binding; protein kinase activity

Biological Process: autophagosome assembly; autophagy; autophagy of peroxisome; cellular response to glucose starvation; cytokinesis; early endosome to late endosome transport; endocytosis; endosome organization and biogenesis; interleukin-7-mediated signaling pathway; macroautophagy; phosphatidylinositol biosynthetic process; phosphatidylinositol phosphorylation; phosphoinositide-mediated signaling; protein amino acid phosphorylation; protein lipidation; protein localization to phagophore assembly site; protein processing; regulation of cytokinesis; regulation of protein secretion; response to leucine; toll-like receptor 9 signaling pathway