Biotin-Linked Polyclonal Antibody to Integrin Alpha 1 (ITGa1)

This gene encodes the alpha 1 subunit of integrin receptors. This protein heterodimerizes with the beta 1 subunit to form a cell-surface receptor for collagen and laminin. The heterodimeric receptor is involved in cell-cell adhesion and may play a role in inflammation and fibrosis. The alpha 1 subunit contains an inserted (I) von Willebrand factor type I domain which is thought to be involved in collagen binding. [provided by RefSeq, Jul 2008]

ITGA1: Integrin alpha-1/beta-1 is a receptor for laminin and collagen. It recognizes the proline-hydroxylated sequence G-F-P-G- E-R in collagen. Belongs to the integrin alpha chain family.

Protein type: Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 5q11.2

Cellular Component: acrosomal vesicle; cell surface; external side of plasma membrane; focal adhesion; integrin complex; membrane; membrane raft; neuron projection; perikaryon; plasma membrane

Molecular Function: collagen binding; metal ion binding; protein binding; protein phosphatase binding; receptor binding

Biological Process: activation of MAPK activity; cell-matrix adhesion; cellular extravasation; extracellular matrix organization; integrin-mediated signaling pathway; muscle contraction; negative regulation of cell proliferation; negative regulation of epidermal growth factor receptor signaling pathway; neuron projection morphogenesis; neutrophil chemotaxis; positive regulation of neuron apoptotic process; positive regulation of phosphoprotein phosphatase activity; vasodilation