BSA Conjugated Parathyroid Hormone (PTH)
Cat# MBS2086333-5mg
Size : 5mg
Brand : MyBiosource
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Phone : +1 850 650 7790
PTH Small Molecule – Parathyroid Hormone
For Research Use Only. Not for use in diagnostic procedures. Special Promotion Catalog #: MBS2086333SPECIAL PROMOTION: Get FREE Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment
MBS2086333 is a small molecule targeting PTH. Also known as BSA Conjugated Parathyroid Hormone (PTH). Host: Protein Conjugation. More details
Product Overview
Product Name
Parathyroid Hormone (PTH), Small Molecule
Full Product Name
BSA Conjugated Parathyroid Hormone (PTH)
Product Gene Name
PTH small molecule
Product Synonym Names
iPTH; Intact Parathyroid Hormone; Parathormone; Parathyrin
Host
Protein Conjugation
Form/Format
Freeze-dried powder
Purity/Purification
> 90%
Preparation and Storage
Avoid repeated freeze/thaw cycles. Store at 2-8 degree C for one month. Aliquot and store at -80 degree C for 12 months.
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
Molecular Weight
12,861 Da
OMIM
V00597 mRNA
Supply Chain Verification
Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.
Buffer Formulation
PBS, pH7.4.
Organism Species
Rat
Usage
Reconstitute in PBS (pH7.4) to a concentration of 0.1-1.0 mg/mL. Do not vortex.
Product Categories/Family for PTH small molecule
ISO Certification
Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.
Applications Tested/Suitable for PTH small molecule
Immunogen, SDS-PAGE, Western Blot (WB)
Other Notes
Small volumes of PTH small molecule vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Additional Details
NCBI/Uniprot data below describe general gene information for PTH. It may not necessarily be applicable to this product.
UniProt Primary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
parathyroid hormone isoform 1 preproprotein
NCBI Official Synonym Full Names
parathyroid hormone
NCBI Official Symbol
PTH
NCBI Official Synonym Symbols
PTH1
UniProt Protein Name
Parathyroid hormone
UniProt Synonym Protein Names
Parathormone; Parathyrin
Protein Family
Parathyroid hormone
UniProt Gene Name
PTH
UniProt Synonym Gene Names
PTH
NCBI Protein Information
parathyroid hormone
NCBI Summary for PTH
This gene encodes a member of the parathyroid family of proteins. The encoded preproprotein is proteolytically processed to generate a protein that binds to the parathyroid hormone/parathyroid hormone-related peptide receptor and regulates blood calcium and phosphate levels. Excess production of the encoded protein, known as hyperparathyroidism, can result in hypercalcemia and kidney stones. On the other hand, defective processing of the encoded protein may lead to hypoparathyroidism, which can result in hypocalcemia and numbness. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]
Show more UniProt Comments for PTH
PTH: PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Stimulates [1-14C]-2- deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblastic cells. Defects in PTH are a cause of familial isolated hypoparathyroidism (FIH); also called autosomal dominant hypoparathyroidism or autosomal dominant hypocalcemia. FIH is characterized by hypocalcemia and hyperphosphatemia due to inadequate secretion of parathyroid hormone. Symptoms are seizures, tetany and cramps. FIH exist both as autosomal dominant and recessive forms of hypoparathyroidism. Belongs to the parathyroid hormone family.
Protein type: Apoptosis; Hormone; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 11p15.3
Cellular Component: extracellular region; extracellular space
Molecular Function: parathyroid hormone receptor binding; peptide hormone receptor binding; RNA polymerase II transcription factor activity, enhancer binding
Biological Process: bone resorption; cAMP metabolic process; G-protein coupled receptor protein signaling pathway; induction of apoptosis by hormones; negative regulation of transcription from RNA polymerase II promoter; positive regulation of bone mineralization; positive regulation of cAMP biosynthetic process; positive regulation of glucose import; positive regulation of glycogen biosynthetic process; positive regulation of transcription from RNA polymerase II promoter; regulation of gene expression; skeletal development
Disease: Hypoparathyroidism, Familial Isolated
Show more Protein type: Apoptosis; Hormone; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 11p15.3
Cellular Component: extracellular region; extracellular space
Molecular Function: parathyroid hormone receptor binding; peptide hormone receptor binding; RNA polymerase II transcription factor activity, enhancer binding
Biological Process: bone resorption; cAMP metabolic process; G-protein coupled receptor protein signaling pathway; induction of apoptosis by hormones; negative regulation of transcription from RNA polymerase II promoter; positive regulation of bone mineralization; positive regulation of cAMP biosynthetic process; positive regulation of glucose import; positive regulation of glycogen biosynthetic process; positive regulation of transcription from RNA polymerase II promoter; regulation of gene expression; skeletal development
Disease: Hypoparathyroidism, Familial Isolated
Research Articles on PTH
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Product Note
Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.
Product PubMed Publications
Products associated with PTH small molecule
| Reference Product | PubMed Publications |
|---|---|
| PTH1R small molecule | >188 publications with PTH and PTH1R |
| PTH2R small molecule | >16 publications with PTH and PTH2R |
Pathways associated with PTH small molecule
| Products by Pathway | Pathway Diagram |
|---|---|
| Class B/2 (Secretin Family Receptors) Pathway antibodies | Class B/2 (Secretin Family Receptors) Pathway Diagram |
| Endochondral Ossification Pathway antibodies | Endochondral Ossification Pathway Diagram |
| G Alpha (s) Signalling Events Pathway antibodies | G Alpha (s) Signalling Events Pathway Diagram |
| GPCR Downstream Signaling Pathway antibodies | GPCR Downstream Signaling Pathway Diagram |
| GPCR Ligand Binding Pathway antibodies | GPCR Ligand Binding Pathway Diagram |
| Osteoblast Signaling Pathway antibodies | Osteoblast Signaling Pathway Diagram |
| Signal Transduction Pathway antibodies | Signal Transduction Pathway Diagram |
| Signaling By GPCR Pathway antibodies | Signaling By GPCR Pathway Diagram |
| Vitamin D Synthesis Pathway antibodies | Vitamin D Synthesis Pathway Diagram |
Diseases associated with PTH small molecule
| Disease Name | Pubmed Publications |
|---|---|
| Hyperparathyroidism Antibodies | >4851 publications with PTH and Hyperparathyroidism |
| Bone Diseases Antibodies | >4134 publications with PTH and Bone Diseases |
| Kidney Diseases Antibodies | >3096 publications with PTH and Kidney Diseases |
| Hyperparathyroidism, Secondary Antibodies | >2664 publications with PTH and Hyperparathyroidism, Secondary |
| Bone Diseases, Metabolic Antibodies | >2493 publications with PTH and Bone Diseases, Metabolic |
| Hypercalcemia Antibodies | >2294 publications with PTH and Hypercalcemia |
| Bone Resorption Antibodies | >2146 publications with PTH and Bone Resorption |
| Renal Insufficiency Antibodies | >1972 publications with PTH and Renal Insufficiency |
| Osteoporosis Antibodies | >1891 publications with PTH and Osteoporosis |
| Kidney Failure, Chronic Antibodies | >1708 publications with PTH and Kidney Failure, Chronic |
Organs/Tissues associated with PTH small molecule
| Organ/Tissue Name | Pubmed Publications |
|---|---|
| Parathyroid Antibodies | >14515 publications with PTH and Parathyroid |
| Connective Tissue Antibodies | >2270 publications with PTH and Connective Tissue |
| Embryonic Tissue Antibodies | >229 publications with PTH and Embryonic Tissue |