c-FER Antibody
Cat# MBS8582813-0,1mL-PE
Size : 0.1mL(PE)
Brand : MyBiosource
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Phone : +1 850 650 7790
c-FER Antibody – Rabbit Polyclonal
For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS8582813MBS8582813 is an antibody targeting c-FER. Also known as c-FER Antibody. Reactive in Human, Mouse, Rat, Bovine, Dog, Monkey, Pig. Host: Rabbit. Rabbit polyclonal antibody to c-FER More details
Product Overview
Online Datasheet in PDFProduct Name
c-FER, Polyclonal Antibody
Full Product Name
c-FER Antibody
Product Gene Name
anti-c-FER antibody
Product Synonym Gene Name
FES
Product Synonym Names
FPS; Tyrosine-protein kinase Fes/Fps; Feline sarcoma/Fujinami avian sarcoma oncogene homolog; Proto-oncogene c-Fes; Proto-oncogene c-Fps; p93c-fes
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat, Bovine, Dog, Monkey, Pig
Form/Format
Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH7.3, 30% glycerol, and 0.01% sodium azide.
Purity/Purification
The antibody was purified by immunogen affinity chromatography.
Specificity
Recognizes endogenous levels of c-FER protein.
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.
Molecular Weight
93,497 Da
Chromosome Location
Chromosome: 15; NC_000015.9 (91427665..91439006). Location: 15q26.1
OMIM
190030
Immunogen
KLH-conjugated synthetic peptide encompassing a sequence within the center region of human c-FER. The exact sequence is proprietary.
Product Categories/Family for anti-c-FER antibody
Primary Antibody
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-c-FER antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-c-FER antibody
WB: 1:500-1:1000
IHC: 1:50-1:200
IHC: 1:50-1:200
Other Notes
Small volumes of anti-c-FER antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Additional Details
NCBI/Uniprot data below describe general gene information for c-FER. It may not necessarily be applicable to this product.
NCBI Official Full Name
tyrosine-protein kinase Fes/Fps isoform 2
NCBI Official Synonym Full Names
feline sarcoma oncogene
NCBI Official Symbol
FES
NCBI Official Synonym Symbols
FPS
UniProt Protein Name
Tyrosine-protein kinase Fes/Fps
UniProt Synonym Protein Names
Feline sarcoma/Fujinami avian sarcoma oncogene homolog; Proto-oncogene c-Fes; Proto-oncogene c-Fps; p93c-fes
Protein Family
Myoferlin
UniProt Gene Name
FES
UniProt Synonym Gene Names
FPS
UniProt Entry Name
FES_HUMAN
NCBI Protein Information
tyrosine-protein kinase Fes/Fps; p93c-fes; proto-oncogene c-Fes; proto-oncogene c-Fps; Oncogene FES, feline sarcoma virus; proto-oncogene tyrosine-protein kinase Fes/Fps; feline sarcoma/Fujinami avian sarcoma oncogene homolog; feline sarcoma (Snyder-Theil
NCBI Summary for c-FER
This gene encodes the human cellular counterpart of a feline sarcoma retrovirus protein with transforming capabilities. The gene product has tyrosine-specific protein kinase activity and that activity is required for maintenance of cellular transformation. Its chromosomal location has linked it to a specific translocation event identified in patients with acute promyelocytic leukemia but it is also involved in normal hematopoiesis as well as growth factor and cytokine receptor signaling. Alternative splicing results in multiple variants encoding different isoforms.[provided by RefSeq, Jan 2009]
Show more UniProt Comments for c-FER
Fes: a non-receptor tyrosine kinase of the Fer family. Appears to be involved in normal hematopoiesis as well as the development of acute promyelocytic leukemia. Contains one SH2 and one FCH domain. Four LOF point mutations seen in colorectal cancer. Orthologous to v-fes from feline leukemia virus and v-fps from avian transforming virus. Mutant forms are angiogenic. Promotes survival during differentiation, and may act both to promote and inhibit tumors. May be disrupted in the t(15q+;17q-) found in acute promyelocytic leukemia, but the breakpoint does not occur within the gene.
Protein type: Oncoprotein; EC 2.7.10.2; Kinase, protein; Protein kinase, tyrosine (non-receptor); Protein kinase, TK; Tumor suppressor; TK group; Fer family
Chromosomal Location of Human Ortholog: 15q26.1
Cellular Component: microtubule cytoskeleton; Golgi apparatus; extrinsic to internal side of plasma membrane; focal adhesion; cytoplasm; cytoplasmic membrane-bound vesicle; cytoplasmic vesicle; cytosol
Molecular Function: protein binding; protein-tyrosine kinase activity; non-membrane spanning protein tyrosine kinase activity; phosphoinositide binding; ATP binding
Biological Process: regulation of cell adhesion; epidermal growth factor receptor signaling pathway; regulation of mast cell degranulation; axon guidance; cell migration; peptidyl-tyrosine phosphorylation; positive regulation of myeloid cell differentiation; multicellular organismal development; protein amino acid autophosphorylation; positive regulation of microtubule polymerization; chemotaxis; protein amino acid phosphorylation; regulation of cell proliferation; cell proliferation; regulation of cell shape; regulation of cell differentiation; innate immune response
Show more Protein type: Oncoprotein; EC 2.7.10.2; Kinase, protein; Protein kinase, tyrosine (non-receptor); Protein kinase, TK; Tumor suppressor; TK group; Fer family
Chromosomal Location of Human Ortholog: 15q26.1
Cellular Component: microtubule cytoskeleton; Golgi apparatus; extrinsic to internal side of plasma membrane; focal adhesion; cytoplasm; cytoplasmic membrane-bound vesicle; cytoplasmic vesicle; cytosol
Molecular Function: protein binding; protein-tyrosine kinase activity; non-membrane spanning protein tyrosine kinase activity; phosphoinositide binding; ATP binding
Biological Process: regulation of cell adhesion; epidermal growth factor receptor signaling pathway; regulation of mast cell degranulation; axon guidance; cell migration; peptidyl-tyrosine phosphorylation; positive regulation of myeloid cell differentiation; multicellular organismal development; protein amino acid autophosphorylation; positive regulation of microtubule polymerization; chemotaxis; protein amino acid phosphorylation; regulation of cell proliferation; cell proliferation; regulation of cell shape; regulation of cell differentiation; innate immune response
Research Articles on c-FER
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Product Note
Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.
Product PubMed Publications
Products associated with anti-c-FER antibody
| Reference Product | PubMed Publications |
|---|---|
| BCR antibody | >24 publications with c-FER and BCR |
| STAT3 antibody | >22 publications with c-FER and STAT3 |
| JAK3 antibody | >5 publications with c-FER and JAK3 |
| JAK2 antibody | >5 publications with c-FER and JAK2 |
| JAK1 antibody | >5 publications with c-FER and JAK1 |
| IRS1 antibody | >5 publications with c-FER and IRS1 |
| IRS2 antibody | >3 publications with c-FER and IRS2 |
| PLXNA1 antibody | >2 publications with c-FER and PLXNA1 |
| HSH2D antibody | >1 publications with c-FER and HSH2D |
| BCAR1 antibody | >1 publications with c-FER and BCAR1 |
Pathways associated with anti-c-FER antibody
| Products by Pathway | Pathway Diagram |
|---|---|
| Angiopoietin Receptor Tie2-mediated Signaling Pathway antibodies | Angiopoietin Receptor Tie2-mediated Signaling Pathway Diagram |
| Axon Guidance Pathway antibodies | Axon Guidance Pathway Diagram |
| Axon Guidance Pathway antibodies | Axon Guidance Pathway Diagram |
| Axon Guidance Pathway antibodies | Axon Guidance Pathway Diagram |
| CRMPs In Sema3A Signaling Pathway antibodies | CRMPs In Sema3A Signaling Pathway Diagram |
| Developmental Biology Pathway antibodies | Developmental Biology Pathway Diagram |
| IL-3 Signaling Pathway antibodies | IL-3 Signaling Pathway Diagram |
| IL-4 Signaling Pathway antibodies | IL-4 Signaling Pathway Diagram |
| IL-6 Signaling Pathway antibodies | IL-6 Signaling Pathway Diagram |
| IL4-mediated Signaling Events Pathway antibodies | IL4-mediated Signaling Events Pathway Diagram |
Diseases associated with anti-c-FER antibody
| Disease Name | Pubmed Publications |
|---|---|
| Neoplasms Antibodies | >352 publications with c-FER and Neoplasms |
| Breast Neoplasms Antibodies | >57 publications with c-FER and Breast Neoplasms |
| Congenital Abnormalities Antibodies | >37 publications with c-FER and Congenital Abnormalities |
| Inflammation Antibodies | >35 publications with c-FER and Inflammation |
| Neoplasms, Experimental Antibodies | >34 publications with c-FER and Neoplasms, Experimental |
| Adenocarcinoma Antibodies | >32 publications with c-FER and Adenocarcinoma |
| Necrosis Antibodies | >27 publications with c-FER and Necrosis |
| Abnormalities, Multiple Antibodies | >20 publications with c-FER and Abnormalities, Multiple |
| Edema Antibodies | >19 publications with c-FER and Edema |
| Neoplasm Metastasis Antibodies | >18 publications with c-FER and Neoplasm Metastasis |
Organs/Tissues associated with anti-c-FER antibody
| Organ/Tissue Name | Pubmed Publications |
|---|---|
| Muscle Antibodies | >753 publications with c-FER and Muscle |
| Blood Antibodies | >345 publications with c-FER and Blood |
| Bone Antibodies | >265 publications with c-FER and Bone |
| Nerve Antibodies | >248 publications with c-FER and Nerve |
| Brain Antibodies | >219 publications with c-FER and Brain |
| Vascular Antibodies | >115 publications with c-FER and Vascular |
| Lung Antibodies | >82 publications with c-FER and Lung |
| Skin Antibodies | >76 publications with c-FER and Skin |
| Bone Marrow Antibodies | >65 publications with c-FER and Bone Marrow |
| Liver Antibodies | >64 publications with c-FER and Liver |