Calcium Sensing Receptor (Phospho-Thr888) Antibody
Cat# MBS859688-0,1mL-PE
Size : 0.1mL(PE)
Brand : MyBiosource
Contact local distributor :
Phone : +1 850 650 7790
P-peptide-+ Western blot analysis of extracts from LOVO cells, using Calcium Sensing Receptor (Phospho-Thr888) antibody. Immunofluorescence analysis of HeLa cells, using Calcium Sensing Receptor (Phospho-Thr888) antibody.
Calcium Sensing Receptor (CASR) Antibody
For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS859688MBS859688 is an antibody targeting CASR. Also known as Calcium Sensing Receptor (Phospho-Thr888) Antibody. Reactive in Human, Mouse, Rat. More details
Product Overview
Online Datasheet in PDFProduct Name
Calcium Sensing Receptor (CASR), Antibody
Full Product Name
Calcium Sensing Receptor (Phospho-Thr888) Antibody
Product Gene Name
anti-CASR antibody
Product Synonym Names
CaSR; Extracellular calcium-sensing receptor precursor; GPRC2A; PCAR1; Parathyroid Cell calcium-sensing receptor
Species Reactivity
Human, Mouse, Rat
Form/Format
In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purity/Purification
Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.
Specificity
Calcium Sensing Receptor (Phospho-Thr888) antibody detects endogenous levels of Calcium Sensing Receptor only when phosphorylated at threonine 888.
Preparation and Storage
Store at-20 degree C for 1 year.
Molecular Weight
121,773 Da
OMIM
145980
Immunogen
The antiserum was produced against synthesized phosphopeptide derived from human Calcium Sensing Receptor around the phosphorylation site of threonine 888 (R-A-TP-L-R).
All Sites
Human: Thr888
Mouse: Thr888
Rat: Thr888
Mouse: Thr888
Rat: Thr888
Product Categories/Family for anti-CASR antibody
Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-CASR antibody
Western Blot (WB), Immunofluorescence (IF), ELISA (EIA)
Application Notes for anti-CASR antibody
WB: 1:500~1:1000
IF: 1:100~1:500
ELISA: 1:40000
IF: 1:100~1:500
ELISA: 1:40000
Product References and Citations for anti-CASR antibody
Garrett J.E., J. Biol. Chem. 270:12919-12925(1995). Aida K., Biochem. Biophys. Res. Commun. 214:524-529(1995). Uckun-Kitapci A., Am. J. Med. Genet. A 132:125-129(2005).
Other Notes
Small volumes of anti-CASR antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Additional Details
NCBI/Uniprot data below describe general gene information for CASR. It may not necessarily be applicable to this product.
NCBI Official Full Name
extracellular calcium-sensing receptor isoform 2
NCBI Official Synonym Full Names
calcium sensing receptor
NCBI Official Symbol
CASR
NCBI Official Synonym Symbols
CAR; FHH; FIH; HHC; EIG8; HHC1; NSHPT; PCAR1; hCasR; GPRC2A; HYPOC1
UniProt Protein Name
Extracellular calcium-sensing receptor
UniProt Synonym Protein Names
Parathyroid cell calcium-sensing receptor 1
Protein Family
Extracellular calcium-sensing receptor
UniProt Gene Name
CASR
UniProt Synonym Gene Names
PCaR1
NCBI Protein Information
extracellular calcium-sensing receptor
NCBI Summary for CASR
The protein encoded by this gene is a plasma membrane G protein-coupled receptor that senses small changes in circulating calcium concentration. The encoded protein couples this information to intracellular signaling pathways that modify parathyroid hormone secretion or renal cation handling, and thus this protein plays an essential role in maintaining mineral ion homeostasis. Mutations in this gene are a cause of familial hypocalciuric hypercalcemia, neonatal severe hyperparathyroidism, and autosomal dominant hypocalcemia. [provided by RefSeq, Aug 2017]
Show more UniProt Comments for CASR
G-protein-coupled receptor that senses changes in the extracellular concentration of calcium ions and plays a key role in maintaining calcium homeostasis (PubMed:7759551, PubMed:8702647, PubMed:8636323, PubMed:8878438, PubMed:17555508, PubMed:19789209, PubMed:21566075, PubMed:22114145, PubMed:23966241, PubMed:25292184, PubMed:25104082, PubMed:26386835, PubMed:25766501, PubMed:22789683). Senses fluctuations in the circulating calcium concentration and modulates the production of parathyroid hormone (PTH) in parathyroid glands (). The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system (PubMed:7759551). The G-protein-coupled receptor activity is activated by a co-agonist mechanism: aromatic amino acids, such as Trp or Phe, act concertedly with divalent cations, such as calcium or magnesium, to achieve full receptor activation (PubMed:27434672, PubMed:27386547).
Show more Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Product Note
Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.
Product PubMed Publications
Pathways associated with anti-CASR antibody
| Products by Pathway | Pathway Diagram |
|---|---|
| Class C/3 (Metabotropic Glutamate/pheromone Receptors) Pathway antibodies | Class C/3 (Metabotropic Glutamate/pheromone Receptors) Pathway Diagram |
| E-cadherin Signaling In Keratinocytes Pathway antibodies | E-cadherin Signaling In Keratinocytes Pathway Diagram |
| G Alpha (i) Signalling Events Pathway antibodies | G Alpha (i) Signalling Events Pathway Diagram |
| G Alpha (q) Signalling Events Pathway antibodies | G Alpha (q) Signalling Events Pathway Diagram |
| GPCR Downstream Signaling Pathway antibodies | GPCR Downstream Signaling Pathway Diagram |
| GPCR Ligand Binding Pathway antibodies | GPCR Ligand Binding Pathway Diagram |
| GPCRs, Class C Metabotropic Glutamate, Pheromone Pathway antibodies | GPCRs, Class C Metabotropic Glutamate, Pheromone Pathway Diagram |
| Gastrin-CREB Signalling Pathway Via PKC And MAPK antibodies | Gastrin-CREB Signalling Pathway Via PKC And MAPK Diagram |
| Signal Transduction Pathway antibodies | Signal Transduction Pathway Diagram |
| Signaling By GPCR Pathway antibodies | Signaling By GPCR Pathway Diagram |
Diseases associated with anti-CASR antibody
| Disease Name | Pubmed Publications |
|---|---|
| Hyperparathyroidism Antibodies | >195 publications with CASR and Hyperparathyroidism |
| Hypercalcemia Antibodies | >165 publications with CASR and Hypercalcemia |
| Hypocalcemia Antibodies | >97 publications with CASR and Hypocalcemia |
| Neoplasms Antibodies | >96 publications with CASR and Neoplasms |
| Kidney Diseases Antibodies | >83 publications with CASR and Kidney Diseases |
| Hyperparathyroidism, Secondary Antibodies | >66 publications with CASR and Hyperparathyroidism, Secondary |
| Hypoparathyroidism Antibodies | >59 publications with CASR and Hypoparathyroidism |
| Hypertension Antibodies | >29 publications with CASR and Hypertension |
| Hyperparathyroidism, Neonatal Severe Primary Antibodies | >21 publications with CASR and Hyperparathyroidism, Neonatal Severe Primary |
| Renal Insufficiency Antibodies | >19 publications with CASR and Renal Insufficiency |
Organs/Tissues associated with anti-CASR antibody
| Organ/Tissue Name | Pubmed Publications |
|---|---|
| Parathyroid Antibodies | >326 publications with CASR and Parathyroid |
| Kidney Antibodies | >195 publications with CASR and Kidney |
| Liver Antibodies | >28 publications with CASR and Liver |
| Pancreas Antibodies | >12 publications with CASR and Pancreas |
| Eye Antibodies | >1 publications with CASR and Eye |